Metals in pharmaceuticals have played an increasingly important role in medicine over the last century, particularly in cancer therapy and diagnostic imaging methods. Medicinal Applications of Coordination Chemistry focuses on the role that transition metals play in clinical applications. Medicinal Applications of Coordination Chemistry begins with a brief historical review and an introduction to the chemistry of d- and f- block metals. Subsequent sections discuss metallodrugs for a number of different applications, the design of new drugs and the relationship between structure and function. Key sections include diagnostic applications of metal compounds in anatomical and functional imaging, and therapeutic applications of metals compounds. This book is ideal for researchers in academia and industry and comes complete with examples of real life applications.
Rezensionen / Stimmen
The section on platinum, like the others, is in general well illustrated with line diagrams of chemical structures, and gives a good coverage of new developments, such as active trans complexes and potent di- and tri-Pt anticancer complexes.This book will serve a useful role in teaching inorganic chemistry to both undergraduate and postgraduate students. The topic helps to 'bring inorganic chemistry to life' and in my experience does arouse their curiosity at all levels. It will be a useful addition to libraries. * Platinum Metals Review, 2008, 52, (1), 21-22 (Peter J Sadler) * In my opinion Jones and Thornback have accomplished their goal, and I am pleased to recommend Medicinal Applications of Coordination Chemistry to pharmacists, clinicians and medical researchers who use metal-containing drugs in a clinical environment. It should also serve as an introductory text for students of chemistry who wish to learn about an aspect of their subject within an applied context rather than just as a subject in its own right. * Chemical Educator, 2007, 12, 443-451 * This book fills a gap between more detailed reference texts in the area and the brief mention the topic is given I undergraduate inorganic chemistry text books.....a valuable addition to the collection of any bioinorganic or medicinal chemist.I would recommend this book as a high quality text that offers detailed and coherent coverage of an important and developing multi-disciplinary research area where classical coordination chemistry principles can be applied to design new medicines. * Chemistry World, August 2007, 68 (Steve Archibald) *
Sprache
Verlagsort
Zielgruppe
Für höhere Schule und Studium
Produkt-Hinweis
Maße
Höhe: 234 mm
Breite: 155 mm
Dicke: 25 mm
Gewicht
ISBN-13
978-0-85404-596-9 (9780854045969)
Copyright in bibliographic data and cover images is held by Nielsen Book Services Limited or by the publishers or by their respective licensors: all rights reserved.
Schweitzer Klassifikation
Honorary Visiting Professor in Radiochemistry, University of Manchester
Autor*in
University of Birmingham (Retired), UK
Preface;
Chapter 1: INTRODUCTION;
1.1: METALS IN MEDICINE - A HISTORICAL PERSPECTIVE;
1.2: METALS AND HUMAN BIOCHEMISTRY;
1.3: METALLOPHARMACEUTICALS;
1.4: THE SPECIAL PROPERTIES OF METALS;
Chapter 2: THE CHEMISTRY OF METALS IN A NUTSHELL;
2.1: THE STRUCTURE OF MATERIALS;
2.2: THE STRUCTURES AND PROPERTIES OF ATOMS;
2.3: THE FORMATION OF COMPOUNDS;
2.4: THE CHEMISTRY OF METALS - AN OVERVIEW;
2.5: BONDING IN METAL COMPLEXES;
2.6: THE MAGNETISM AND SPECTROSCOPY OF METAL COMPLEXES;
2.7: THE ENERGETICS OF METAL COMPLEX FORMATION;
2.8: REACTIONS AT METAL CENTRES;
2.9: REDOX POTENTIALS;
2.10: CONCLUSIONS;
Chapter 3: DIAGNOSTIC MEDICINE;
3.1: INTRODUCTION;
3.2: ANATOMICAL IMAGING;
3.3: FUNCTIONAL IMAGING;
3.4: In vitro APPLICATIONS;
Chapter 4: THERAPEUTIC MEDICINE;
4.1: THE USE OF METAL COMPOUNDS IN THERAPY;
4.2: CHELATION THERAPY;
4.3: CANCER THERAPY;
4.4: RHEUMATOID ARTHRITIS;
4.5: DIABETES;
4.6: CARDIOVASCULAR SYSTEM;
4.7: THERAPEUTIC RADIOPHARMACEUTICALS;
Chapter 5: METALLOPHARMACEUTICAL DESIGN;
5.1: INTRODUCTION;
5.2: STRUCTURE ACTIVITY RELATIONSHIPS;
5.3: FUTURE DIRECTIONS
