Foreword: Herwald, H.; Egesten, A.; Roger C. Bone, MD and the Evolving Paradigms of Sepsis: Balk, R.; Clinical Aspects of Sepsis: Holub, M.; Zavada, J.; Virulence Factors of Gram-Negative Bacteria in Sepsis with a Focus on Neisseria meningitidis: Livorsi, D.J.; Stenehjem, E.; Stephens, D.S.; Molecular Mechanisms of Sepsis: Russell, J.A.; Boyd, J.; Nakada, T.; Thair, S.; Walley, K.R.; Pro-Inflammatory Mechanisms in Sepsis: Chong, D.L.W.; Sriskandan, S.; Anti-Inflammatory Mechanisms of Sepsis: Shubin, N.J.; Monaghan, S.F.; Ayala, A.; Regulation of Pro- and Anti-Inflammatory Host Responses: van der Poll, T.; van Zoelen, M.A.D.; Wiersinga, W.J.; Future Perspectives on Regulating Pro- and Anti-Inflammatory Responses in Sepsis: Delsesto, D.; Opal, S.M.; Author Index; Subject Index.