Ischemia

This publication represents an up-to-date summary of the current understanding of reoxygenation injury in skeletal muscle and outlines future directions of those who will lead the way in this field. Skeletal muscle is generally more tolerant of ischemia reperfusion injury than other organ systems such as brain, heart, kidney, liver and bowel. Current knowledge regarding the pathophysiology of such injury has attracted correspondingly less attention and has been relatively slow to accumulate. This monograph brings together acknowledged leaders who have focused their research efforts on identifying mechanisms of reoxygenation injury in skeletal muscle; the virtual plethora of pathways and cytokines involved in the mediation of cellular injury is attested to by the number and diversity of chapters.