Preface vii About the Editor ix Contributors xi 1. Evolving Role of Mass Spectrometry in Drug Discovery and Development 1 Dil M. Ramanathan and Richard M. LeLacheur 2. Quantitative Bioanalysis in Drug Discovery and Development: Principles and Applications 87 Ayman El-Kattan, Chris Holliman, and Lucinda H. Cohen 3. Quadrupole, Triple-Quadrupole, and Hybrid Linear Ion Trap Mass Spectrometers for Metabolite Analysis 123 Elliott B. Jones 4. Applications of Quadrupole Time-of-Flight Mass Spectrometry in Reactive Metabolite Screening 159 Jose M. Castro-Perez 5. Changing Role of FTMS in Drug Metabolism 191 Petia A. Shipkova, Jonathan L. Josephs, and Mark Sanders 6. High-Resolution LC-MS-Based Mass Defect Filter Approach: Basic Concept and Application in Metabolite Detection 223 Haiying Zhang, Donglu Zhang, Mingshe Zhu, and Kenneth L. Ray 7. Applications of High-Sensitivity Mass Spectrometry and Radioactivity Detection Techniques in Drug Metabolism Studies 253 Wing W. Lam, Cho-Ming Loi, Angus Nedderman, and Don Walker 8. Online Electrochemical-LC-MS Techniques for Profiling and Characterizing Metabolites and Degradants 275 Paul H. Gamache, David F. Meyer, Michael C. Granger, and Ian N. Acworth 9. LC-MS Methods with Hydrogen/Deuterium Exchange for Identification of Hydroxylamine, N-Oxide, and Hydroxylated Analogs of Desloratadine 295 Natalia A. Penner, Joanna Zgoda-Pols, Ragu Ramanathan, Swapan K. Chowdhury, and Kevin B. Alton 10. Turbulent-Flow LC-MS: Applications for Accelerating Pharmacokinetic Profiling and Metabolite Identification 311 Joseph L. Herman and Joseph M. Di Bussolo 11. Desorption Ionization Techniques for Quantitative Analysis of Drug Molecules 341 Jason S. Gobey, John Janiszewski, and Mark J. Cole 12. MALDI Imaging Mass Spectrometry for Direct Tissue Analysis of Pharmaceuticals 359 Yunsheng Hsieh and Walter A. Korfmacher Index 383
