Foreword ( Tom Baillie ). Preface ( Mike Lee and Mingshe Zhu ). Contributors. Part I. Basic Concepts of Drug Metabolism and Disposition. 1. Progression of Drug Metabolism ( Ronald E. White ). 2. Common Biotransformation Reactions ( Bo Wen and Sidney D. Nelson ). 3. Metabolic Activation of Organic Functional Groups Utilized in Medicinal Chemistry ( Amit S. Kalgutkar ). 4. Drug-Metabolizing Enzymes, Transporters, and Drug-Drug Interactions ( Steven W. Louie and Magang Shou ). 5. Experimental Models of Drug Metabolism and Disposition ( Gang Luo, Chuang Lu, Xinxin Ding, and Donglu Zhang ). 6. Principles of Pharmacokinetics: Predicting Human Pharmacokinetics in Drug Discovery ( Takehito Yamamoto, Akihiro Hisaka, and Hiroshi Suzuki ). 7. Drug Metabolism Research as Integral Part of Drug Discovery and Development Processes ( W. Griffith Humphereys ). Part II. Mass Spectrometry in Drug Metabolism: Principles and Common Practice. 8. Theory and Instrumentation of Mass Spectrometry ( Gerard Hopfgartner ). 9. Common Liquid Chromatography-Mass Spectrometry (LC-MS) Methodology for Metabolite Identification ( Lin Xu, Lewis J. Klunk, and Chandra Prakash ). 10. Mass Spectral Interpretation (Li-Kang Zhang and Birendra N. Pramanik). 11. Techniques to Facilitate the Performance of Mass Spectrometry: Sample Preparation, Liquid Chromatography, and Non-Mass-Spectrometric Detection ( Mark Hayward, Maria D. Bacolod, Qing Ping Han, Manuel Cajina, and Zack Zou ). Part III. Applications of New LC-MS Techniques in Drug Metabolism and Disposition. 12. Quantitative In Vitro ADME Assays Using LC-MS as a Part of Early Drug Metabolism Screening ( Walter Korfmacher ). 13. High-Resolution Mass Spectrometry and Drug Metabolite Identification ( Russell J. Mortishire-Smith, Haiying Zhang, and Kevin P. Bateman ). 14. Distribution Studies of Drugs and Metabolites in Tissue by Mass Spectrometric Imaging ( Richard F. Reich, Daniel P. Magparangalan, Timothy J. Garrett, and Richard A. Yost ). 15. Use of Triple Quadrupole-Linear Ion Trap Mass Spectrometry as a Single LC-MS Platform in Drug Metabolism and Pharmacokinetics ( Wenying Jian, Ming Yao, Bo Wen, Elliott B. Jones, and Mingshe Zhu ). 16. Quantitative Drug Metabolism with Accelerator Mass Spectrometry ( John S. Vogel, Peter Lohstroh, Brad Keck, and Stephen R. Dueker ). 17. Standard-Free Estimation of Metabolite Levels Using Nanospray Mass Spectrometry: Current Statutes and Future Directions ( Jing-Tao Wu ). 18. Profiling and Characterization of Herbal Medicine and Its Metabolites Using LC-MS ( Zeper Abliz, Ruiping Zhang, Ping Geng, Dongmei Dai, Jiuming He, and Jian Liu ). 19. Liquid Chromatography Mass Spectrometry Bioanalysis of Protein Therapeutics and Biomarkers in Biological Matrices ( Fumin Li and Qin C. Ji ). 20. Mass Spectrometry in the Analysis of DNA, Protein, Peptide, and Lipid Biomarkers of Oxidative Stress ( Stacy L. Gelhaus and Ian A. Blair ). 21. LC-MS in Endogenous Metabolite Profiling and Small-Molecule Biomarker Discovery ( Michael D. Reily, Petia Shipkova, and Serhiy Hnatyshyn ). Appendix. Index.
