I Introduction.- Why a Handbook on Chronic Care?.- What is Chronic Care? Perspectives from science, research, education, and practice.- Transdisciplinarity - Chronic Care as a transdisciplinary field.- Chronic Care as a multiprofessional practice field with profession-specific approaches.- II Individual Level: medical aspects, theories of illness, illness experience, coping with illness, practical concepts.- Morphology of chronic diseases.- Prevalence of chronic diseases.- Etiology of chronic diseases.- The masticatory system and chronic diseases.- Multimorbidity and chronic diseases.- Effects of chronic diseases.- Disease trajectories as a shared orientation model for multiprofessional care practice.- Somatic theories of illness and coping.- Sociological perspectives on the social construction of illness and implications for the experience and treatment of illness.- Psychological and psychosomatic approaches to illness.- Human-environment relationships in the context of illness.- Social determinants of health and chronic diseases.- Professional approaches to subjective illness experience.- Salutogenesis, resilience, and coping.- Health literacy.- Setting-specific care: connectivity as a challenge.- Person- and patient-centeredness as care concepts.- Palliative and end-of-life care as care concepts.- Emergency and critical care as care concepts.- Pharmacotherapy, polypharmacy, and adherence.- Technical support systems in individual care.- What if? Social design as a competence expansion in interdisciplinary teams in the context of Chronic Care.- Digital assistance systems for the care of people with chronic illnesses.- III Organizational Level Chronic Care: fundamental aspects, institutional forms of care, and self-determined living.- Migration and Chronic Care.- Transculturality, cultural appropriateness, cultural sensitivity, cultural competence in health care.- Structured care: prevention - cure - rehabilitation - long-term care.- Interfaces and transitions in the care of people with chronic illnesses.- Human resource development and staffing needs considering chronic care.- Interprofessional action and competencies for interprofessional collaboration.- Knowledge management in multiprofessional care processes.- Setting-specific process planning and organizational development.- Concepts of digitalization from the organizational perspective.- Normality and equality in self-determined living with chronic illness.- Chronic illness - a family matter.- Self-determined living at home: diversity of living arrangements.- Household-related services for self-determined living.- IV System Level Chronic Care: framework conditions, health care economics, community and public health care, digital health as a societal innovation.- Basics of social law in health care.- Legal guardianship under the guardianship law.- Organizational forms of the health system.- Health policy concepts for the care of people with chronic illnesses.- Introduction to health care economics.- Principles of business administration in facilities for chronic care.- Methods of health system evaluation and health indicators.- Public health - needs and forward-looking services with a focus on community health nursing and digitalization.- Community health care: stakeholders, concepts, and needs-based service development.- Healthy cities: access to participation and inclusion in neighborhoods.- Public health crises and public health emergency preparedness.- One Health - environment and health in the context of chronic diseases.- Status quo and development trends in digital health.- Ethical aspects of using technical systems for vulnerable individuals.- Tools for evaluating the usefulness and effectiveness of digital technologies.- V Implementation of Chronic Care.- Implementation of transdisciplinary didactic concepts.- Research-based approaches to Chronic Care Science.- Practice-based challenges in Chronic Care Practice.