Active neuroscientists survey NSCs as potential tools for central nervous system and spinal cord repair by explaining their clinically significant fundamental properties, manipulations, and potential therapeutic paradigms. Their discussion of the fundamental biology of NSCs illustrates the signaling pathways that regulate stem cell division and differentiation, and defines the methods of NSC expansion and propagation, neuromorphogenesis, the factors determining cell fate both in vitro and in situ, and the induction of self-reparative processes within the brain. They also present strategies that may lead to fruitful clinical applications in the near future. These range from the replacement of degenerated, dysfunctional, or maldeveloped cells to the provision of factors that may protect, correct, recruit, promote self-repair, or mediate the connectivity of host cells.
Rezensionen / Stimmen
"The purpose is to address research protocols and possible future applications of neural stem cells in clinical practice. The author has met the objectives. . .Starting from the basic aspects of cell culturing, this book emphasizes the different available research protocols that are currently being used for possible management of neurological degenerative diseases. In addition, molecular mechanisms of interaction are always explained whenever necessary. This book is a perfect purchase for neurologists and neuroscientists. Neurosurgeons with a basic science interest would also find this a useful acquisition."-Doody's Health Sciences Book Review Journal
Reihe
Sprache
Verlagsort
Verlagsgruppe
Illustrationen
1
53 farbige Abbildungen, 1 s/w Abbildung
XIX, 434 p. 54 illus., 53 illus. in color.
Dateigröße
ISBN-13
978-1-59259-298-2 (9781592592982)
DOI
10.1007/978-1-59259-298-2
Schweitzer Klassifikation
I: Stem Cells for and from the CNS: Their Source and Fundamental Properties.- 1 Sources of Cells for CNS Therapy.- 2 Neural Stem Cells and Their Plasticity.- 3 Identification, Selection, and Use of Adult Human Oligodendrocyte Progenitor Cells.- 4 Generation, Characterization, and Transplantation of Immortalized Human Neural Crest Stem Cells.- 5 The Search for Neural Progenitors in Bone Marrow and Umbilical Cord Blood.- II: In Vitro and/or In Vivo Manipulations of Stem/Progenitor Cells for the CNS.- 6 Signal Transduction Pathways That Regulate Neural Stem Cell Division and Differentiation.- 7 Neural Stem/Progenitor Cell Clones or "Neurospheres": A Model for Understanding Neuromorphogenesis.- 8 Neural Stem Cells and Specification of Cell Fates: Biological and Therapeutical Perspectives.- 9 Manipulation of Neural Precursors In Situ: Potential for Brain Self-Repair.- 10 Neural Stem Cells in the Adult Hippocampus.- III: Stem/Progenitor Cells in Representative TherapeuticParadigms for the CNS.- 11 Global Gene and Cell Replacement Strategies via Stem Cells.- 12 Neural Stem Cells in and from the Spinal Cord.- 13 Stem Cells for Spinal Cord Injury.- 14 Spinal Ischemia-Induced Paraplegia: A Potential Therapeutical Role of Spinally GraftedNeural Precursors and Human hNT Neurons.- 15 Utilization of Marrow Stromal Cells for Gene Transfer into the CNS.- 16 Preclinical Basis for Use of NT2N Cells in Neural Transplantation Therapy.
