Drug Metabolism in Drug Design and Development

Preface.
Contributors.
Part I: Basic Concepts of Drug Metabolism.
1. Overview: Drug Metabolism in the Modern PharmaceuticalIndustry (Scott J. Grossman)
2. Oxidative, Reductive, and Hydrolytic Metabolism of Drugs (F.Peter Guengerich)
3. Conjugative Metabolism of Drugs (Rory Remmel, Swati Nagar andUpendra Argikar)
4. Enzyme Kinetics (Timothy S. Tracy)
5. Metabolism-Mediated Drug-Drug Interactions (Hongjian Zhang,Michael W. Sinz, and A. David Rodrigues)
6. Drug Transporters in Drug Disposition, Drug Interactions, andDrug Resistance (Cindy Q. Xia, Johnny J. Yang, and Suresh K.balani)
7. Regulatory Considerations of Drug Metabolism and DrugInteraction Studies (Xiaoxiong Wei and Mingshe Zhu)
Part II: Role of Drug Metabolism in the PharmaceuticalIndustry.
8. Drug Metabolism Research as an Integral Part of the DrugDiscovery Process (W. Griffith Humphreys)
9. Role of Drug Metabosim in Drug Development (Ramaswamy Iyerand Donglu Zhang)
Part III: Analytical techniques in Drug Metabolism.
10. Applications of Liquid Radiochromatography Techniques inDrug Metabolism Studies (Mingshe Zhu, Weiping Zhao, and W. GriffithHumphreys)
11. Application of Liquid Chromatogrpahy/Mass Spectrometry forMetabolite Identification (Shuguang Ma and Swapan K. Chowdhury)
12. Introductin to NMR and Its Application in MetaboliteStructure Determination (Xiaohua Huang, Robert Powers, AdrienneTymiak, Robert Espina, and Vikram Roongta)
Part IV: Common Experimental Approaches andProtocols.
13. Determination of Metabolic Rats and Enzyme Kinetics (Zhi-YiZhang and Laurence S. Kaminsky)
14. Protocols for Assessment of In vitro and In vivoBioactivation Potential of Drug Candidates (Zhoupeng Zhang andJinping Gan)
15. Reaction Phenotyping (Susan Hurst, J. Andrew Williams, andSteven Hansel)
16. Analysis of In vitro Cytochrome P450 Inhibition in DrugDiscovery and Development (Magang Shou and Renke Dai)
17. Testing Drug Candidates for CYP3A4 Induction (Gang Luo,Liang-Shang Gan, and Thomas M. Guenthner)
18. ADME Studies in Animals and Humans: Experimental Design,Metabolite Profoling and Identification, and Data Presentation(Donglu Zhang and S. Nilgun Comezoglu)
Index.