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This book provides an updated and comprehensive overview of cough, while opening new perspectives for their treatment and management. It enables readers to not only discover new physiologic features and mechanisms but also to gain an in-depth understanding of the diagnostic workup of cough, still one of the most frequent and challenging symptoms in daily medical practice.
The book also provides insights into cough's features and pathogenesis, as well as into pharmacologic and non-pharmacologic treatments. The most frequent causes of chronic cough (asthma, postnasal drip, gastroesophageal reflux and chronic hypersensitivity syndrome) and different types of pediatric cough are also explored.
Giovanni Fontana is associate professor of Respiratory Medicine at the University of Florence, Department of Critical Care Medicine and Surgery Consultant in Respiratory Medicine at the hospital "I Fraticini". He is also associate director of the diagnostic laboratory of the Respiratory Pathophysiology Unit at the University of Florence. He is fellow of the Royal College of Physicians, member of the European Respiratory Society, Italian Society of Respiratory Medicine and International Society for Study of Cough. His research interests include the pathophysiology of asthma, neurophysiology of breathing, respiratory control in humans, control of airway smooth muscle, airway defense mechanisms and the clinical physiology of cough.
Donatella Mutolo, PhD, is Associate professor of Physiology at the University of Florence, Department of Experimental and Clinical Medicine, Section of Physiology. She is a member of the American Physiological Society and the Physiological Society of Italy. Her research activity has been devoted to several projects concerning the central nervous mechanisms involved in the respiratory rhythmogenesis and in the mediation of airway defensive reflexes, especially the cough reflex. Her laboratory has developed this line of research obtaining important results on central mechanisms implicated in the down- and up-regulation of the cough reflex by using microinjection techniques, emphasizing the importance of two medullary structures, the caudal nucleus tractus solitarii and the caudal ventral respiratory group.
Preface.- PART A: Cough Sensorimotor Mechanisms.- 1. Physiology of cough.- 2. Sensory pathways and neural modulation of cough.- 3. Brainstem structures involved in the generation of reflex cough.- 4. The Cough Motor Pattern.- Part B: Clinical Assessment of Cough.- 5. Acute and chronic cough.- 6. Cough Hypersensitivity Syndrome.- 7. Clinical Methods for the study of cough.- 8. Diagnostic approach to adult chronic cough patients.- 9. Pediatric cough.- Part C: Cough Therapy.- 10. Pharmacological therapy of acute and chronic cough.- 11. Emerging drugs for chronic cough.
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