Vitamin B12

Name: Vitamin B12 | Proceedings of the 3rd European Symposium on Vitamin B12 and Intrinsic Factor, University of Zurich, March 5-8, 1979, Zurich, Switzerland
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Proceedings of the 3rd European Symposium on Vitamin B12 and Intrinsic Factor, University of Zurich, March 5-8, 1979, Zurich, Switzerland

B. Zagalak W. Friedrich 1979, Zürich> European Symposium on Vitamin B 12 and Intrinsic Factor <3 Universität <Zürich>(Herausgeber*in)

De Gruyter (Verlag)

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Erschienen am 8. Oktober 2019

XVII, 1212 Seiten

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Intro
Preface
CONTENTS
Chapter 1. CHEMISTRY OF CORRINOIDS. TOTAL SYNTHESIS OF VITAMIN B⊂&12&/sub&
Introductory remarks for opening of 3rd European Symposium on vitamin B⊂&12&/sub&
Introductory remarks. Historical perspectives on the isolation of crystalline vitamin B⊂&12&/sub&
New and old problems in the structure analysis of vitamin B⊂&12&/sub&
Synthetic vitamin B⊂&12&/sub&
Chemical synthesis of corrinoids: current problems and recent advances
Recent studies on the synthesis of vitamin B⊂&12&/sub&
New reactions of the chromophoric system of vitamin B⊂&12&/sub& derivatives
Structure and reactivity of the so-called stable yellow corrinoids
Concerning the structure of so-called yellow products obtained from naturally occurring metal-free corrinoids
Correlation of vitamin B⊂&12 &/sub& methanolysis products with cobyrinic methyl ester amides prepared from hydrogenobyrinic acid amides
Preparation and X-ray structural analyses of a cobyrinic acid diamide and the corresponding rhodium analogue
Concerning a new corrinoid from municipal sludge
Steric course of the substitution by vitamin B⊂&12s&/sub& as studied by ⊃&1&/sup&H-NMR spectroscopy
Synthesis and X-ray analysis of a porphyrin-type Co(I)-complex
Stereochemistry of the formation and cleavage of the Co-C bond in a vitamin B⊂&12&/sub& model
The structure of superoxocobalamin, a single crystal ESR study
NMR studies of a novel form of vitamin B⊂&12&/sub&
Circular dichroism study of organocobalamins
Concerning electronic, CD and ORD spectra of isomeric pairs of several (Co-methyl)-corrinoids
Some properties of cobalaminhexacyanoferrate
Temperature-jump kinetics of the "base-on" - "base-off" equilibrium of methylcobalamin
Electrochemistry of vitamin B⊂&12&/sub&. Equilibria, kinetics and mechanisms in the B⊂&12a&/sub& - B⊂&12r&/sub& - B⊂&12s&/sub& oxido-reduction
Electrochemistry of vitamin B⊂&12&/sub&. Alkyl cobalamins and cobinamides
Chapter 2. BIOSYNTHESIS OF CORRINOIDS
Recent biosynthetic researches on vitamin B⊂&12&/sub&
Intermediary metabolism of cobyrinic acid biosynthesis
On the methylation process in cobyrinic acid biosynthesis
Biogenesis of tetrapyrrole compounds (porphyrins and corrinoids), and its regulation
Factor I ex Clostridium tetanomorphum: proof of structure and relationship to vitamin B⊂&12&/sub& biosynthesis
On the biosynthesis of the 5,6-dimethylbenzimidazole moiety of vitamin B⊂&12&/sub&
The enzyme system of propionic acid bacteria transforming riboflavin into 5,6-dimethylbenzimidazole
Straight approaches to the nucleotide loop
Ribosomal proteins share in vitamin B⊂&12&/sub& biosynthesis
The ribosomal proteins L2, L5, L18 and L25 involved in vitamin B⊂&12&/sub& biosynthesis
Formation and role of vitamin B⊂&12&/sub& in Protaminobacter ruber and Rhizobium meliloti
Chapter 3. CORRINOID DEPENDENT ENZYMES AND REACTIONS. MODEL SYSTEMS
Current status of the mechanism of action of B⊂&12&/sub& - coenzyme
A stereochemical approach to the diol dehydratase reaction
Coenzyme B⊂&12&/sub&-dependent diol dehydratase - distribution and metabolic role in Enterobacteriaceae, enzymological properties and interaction with coenzyme B⊂&12&/sub&
Adenosylcobalamin-dependent glycerol dehydratase interaction with substrates and their analogs
Glycerol dehydratase from Aerobacter aerogenes
The mechanism of action of methylmalonyl-CoA mutase as studied with isotope labelling and synthetic models
Recent studies on the mechanism of action of ethanolamine ammonia-lyase
Studies on the mechanism of reactions catalysed by ethanolamine ammonia-lyase
Steric course of the ethanolamine-ammonia lyase reaction
The chemical synthesis and coenzymatic properties of analogs of adenosylcobalamin in the ribonucleotide reductase reaction
Review of the EPR of B⊂&12r&/sub& and B⊂&12&/sub& -dependent enzyme reactions
Vitamin B⊂&12&/sub&: current problems and recent advances
The role of corrinoids in the total synthesis of acetate from C0⊂&2&/sub&
Mechanisms for B⊂&12&/sub& -dependent methylation
Nonenzymic models for the enigmatic coenzyme B⊂&12&/sub&-dependent carbon-skeleton rearrangements
The mechanism of action of coenzyme B⊂&12&/sub&
Model systems for adenosylcobalamin dependent enzymic reactions
Bridged cobaloximes as vitamin B⊂&12&/sub& models
Modified adenosylaobalamin: model systems for the active sites of corrinoid-dependent enzymes
Chapter 4. ANALOGUES AND ANTAGONISTS OF VITAMIN B⊂&12&/sub&
Naturally occurring vitamin B⊂&12&/sub& antagonists and their potential therapeutic value
Structures of some vitamin B⊂&12&/sub& analogues and their biological as well as biochemical functions
Novel metal-free corrinoids and metal analogues
Preparation of ferribalamin, the Fe(III)-analogue of vitamin B⊂&12&/sub&
Chapter 5. VITAMIN B⊂&12&/sub& ASSAY
Vitamin B⊂&12&/sub& assay: an evaluation of radiodilution assay using cobinamide to increase specificity
Effect of residual extract products and the type of binders (R or IF) on serum vitamin B⊂&12&/sub& levels by radioisotope dilution assay
Differential assay of cobamides in serum using R-protein radioisotopic dilution assay, E.coli and E.gracilis assays
Rapid determination of corrinoids by high performance liquid chromatography
Determination of the plasma cobalamins by one-dimensional thin-layer chromatography
Chemical quantitation of corrinoids
Enzymatic estimation of vitamin B⊂&12&/sub&
Essential prerequisites for the analysis of cyanocobalamin in biochemically complex samples using radiometric competitive binding assays
Chapter 6. ABSORPTION, TRANSPORT AND DISTRIBUTION OF VITAMIN B⊂&12&/sub&
Distribution of cobalamins in the animal body
Vitamin B⊂&12&/sub& in membrane mimetic agents - theoretical considerations and practical applications
Transport of vitamin B⊂&12&/sub& in Escherichia coli
The plasma transport of cobalamin (Cbl)
Soluble and membrane-bound vitamin B⊂&12&/sub& transport proteins
The origin and clinical implications of vitamin B⊂&12&/sub& binders - the transcobalamins
Large vitamin B⊂&12&/sub&-binding proteins and complexes in human serum
Heterogeneity of antibodies against B⊂&12&/sub& binders in pernicious anaemia
The intraluminal phase of vitamin B⊂&12&/sub& transport in humans
Polymorphic variants of transcobalamin II rare alleles in family studies
Relationship between cobalophilin releasing and functional state of polymorphonuclear granulocytes
The significance of vitamin B⊂&12&/sub& binders in the central nervous system
In vitro acid dissociation of cobalamin-transcobalamin II complexes formed in vivo: a probe in the study of TC II-kinetics
Calcium dependencies in the binding of transcobalamins to subcellular particles of liver cells
The effect of antibiotics on transcobalamin II synthesis in rabbit liver cell culture
Solubilization and characterization of the transcobalamin II acceptor from human placenta and rabbit liver
Strength of binding of methyl-, 5 '-deoxyadenosyl-, cyano- and hydroxocobalamin to human transcobalamin I and II and intrinsic factor
Adsorptive endocytosis of transcobalamin II-vitamin B⊂&12&/sub& by isolated rat liver parenchymal cells
Species specificity between TC II, TC II-Cbl uptake and anti-TC II
Transcobalamin II polymorphism in african populations
Transcobalamins during induction of nutritional cobalamin deficiency in the fruit bat
Heterogeneity of transcobalamin II demonstrated by isoelectric focusing in urea
Radioimmunosorbent determinations of unsaturated and total transcobalamin II in human serum
The "dU suppression test" and "thymidine suppression test": evidence for reciprocal relationship between the "de novo" and "salvage" pathways of DNA synthesis
TC II deficiency: observations with deoxyuridine suppression test
Spectral studies on hog intrinsic factor and hog non-intrinsic factor
Amino terminal sequence of hog non-intrinsic factor and hog intrinsic factor
Subunit structure of the pig ileal intrinsic factor receptor
Cobinamide blocking assay for intrinsic factor
Intracelular transport of vitamin B⊂&12&/sub& in enterocytes
Evidence for the chief cell as the source of intrinsic factor secretion in the rat
Long-term treatment of pernicious anemia patients with intrinsic factor
An analogy of cobalamin membrane transport: an intestinal receptor for heme
A simplified method for quantitative determination of vitamin B⊂&12&/sub& absorption
Vitamin B⊂&12&/sub& absorption studies with plastic whole body counter in patients with gastroenterological operation
Affinity photo-release purification of cobalamin-binding proteins
Effect of pentagastrin in vitamin B⊂&12&/sub& absorption in the guinea pig
Synthesis of cobalamin coenzymes in the rat and their secretion from the liver into plasma and bile
The pattern of cobalamins in human erythrocytes
Presence of sulfitocobalamin in cell extracts. Resolution and identification by SP-Sephadex C-25 cation exchange chromatography
Mitochondrial cobalamins: types, sources, and functions with evidence of their noninvolvement in mitochondrial DNA synthesis
Chapter 7. PHYSIOLOGY AND PATHOLOGY OF VITAMIN B⊂&12&/sub&
Studies on vitamin B⊂&12&/sub& and ubiquinone
Haematological aspects of cobalamin deficiency
The neurology of vitamin B⊂&12&/sub& deficiency
Clinioal diseases related to defioienoies of vitamin B⊂&12&/sub& transport proteins
Effects of methylaobalamin on peripheral neuropathies or experimentally-induced neuropathies
Inherited deficiencies of the deoxyadenosylcobalamin (Ado-Cbl) dependent L-methylmalonyl-CoA mutase system: clinical and biochemical aspects
An investigation of a possible role for coenzyme B⊂&12&/sub& in ribonucleotide reduction in rabbit bone marrow
Participation of cAMP in regulation of coenzyme B⊂&12&/sub& dependent glycerol dehydratase synthesis from Klebsiella pneumoniae ATCC 85955
Carbon monoxide oxidation by Clostridia: evidence for the involvement of a corrinoid-like compound
The in vivo effects of nitrous oxide on human bone marrow - a morphological, biochemical and cell cycle study
Interconversion of cobalamins in human lymphocytes in vitro and the influence of nitrous oxide on synthesis of cobalamin coenzymes
Studies on cobalamin and folate metabolism in rats exposed to nitrous oxide (N⊂&2&/sub&O)
Alterations in mammalian cells induced by inactivation of vitamin B⊂&12&/sub& with nitrous oxide
High ascorbic acid intake and vitamin B⊂&12&/sub& status in the rat
Ability of megadoses of vitamin C to destroy vitamin B⊂&12&/sub& and cobinamide and to reduce absorption of vitamin B⊂&12&/sub& (with a note on B⊂&12&/sub& radioassays)
Interaction between methylcobalamin and some amino acids in single cell proteins
Methylcobalamin and the modification of proteins in vitro
Deoxyadenosylcobalamin and the process of methylation of tRNA in model systems
The participation of coenzyme B⊂&12&/sub& in the synthesis of DNA by Propionibacterium shermanii
Recent advances in cobalamin metabolism: abnormalities in coenzyme distribution in tumor development and in inherited metabolic disease
On some properties of the effect and metabolism of different cobalamins in tumor-bearing rats
Gastric cancer as a risk factor in pernicious anaemia
Interference with cobalamin metabolism and tumour growth by an analogue of methylcobalamin
Vitamin B⊂&12&/sub& requirement for replication of mouse leukemia L1210 cells: functional relevance to folate metabolism
Vitamin B⊂&12&/sub& and folia acid interrelations: a new look
The effect of hypothyroidism on histidine oxidation and folate-dependent enzyme levels
Cobalamin-dependent methionine synthesis and the regulation of the metabolism of activated folic acid derivatives in cultured human lymphoblasts
Author and Citation Index
Subject Index
Collection of Photographs from the Symposium

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