Pathway Analysis for Drug Discovery

Preface.
Contributors.
1 Introduction to Pathway Analysis (Anton Yuryev).
2 Software Infrastructure and Data Model for Pathway Analysis(Fedor Bokov and Anton Yuryev).
3 Automatic Pathway Inference in Heterogeneous BiologicalAssociation Networks (Anton Yuryev, Andrey Kalinin, and NikolaiDaraselia).
4 Algorithmic Basis for Pathway Visualization (SergeySimakov, Iaroslav Ispolatov, Sergei Maslov, and AlexanderNikitin).
5 Pathway Analysis of High-Throughput Experimental Data(Andrey Y. Sivachenko).
6 Integrative Pathway Analysis of Disease Molecular Data(Andrej Bugrim, Zoltan Dezso, Yuri Nikolsky, and TatianaNikolskaya).
7 Whole-Genome Expression Profi ling of Papillary Serous OvarianCancer: Activated Pathways, Potential Targets, and Noise (JohnFarley, Laurent L. Ozbun, and Michael J. Birrer).
8 Mammalian Proteome and Toxicant Network Analysis (SeanEkins and Craig N. Giroux).
9 Unraveling Mechanisms of Toxicity with the Power of Pathways:ToxWiz Tool as an Illustrative Example (Mark P. Kühnel,Bojana Cosovic, Goran Medic, Robert B. Russell, and GordanaApic).
10 Impact of Chemistry Information on Pathway Analysis(Sreenivas Devidas).
11 Propagation of Concentration Perturbations in EquilibriumProtein Binding Networks (Sergei Maslov and IaroslavIspolatov).
12 An Adaptive System Model of the Yeast Glucose Sensor System(Todor Vujasinovic and André SiniSaZampera).
13 Present and Future of Pathway Analysis in Drug Discovery(Anton Yuryev).
Index.