This book focuses on the three most important aspects of ageing research: nutrition, physical exercise and epigenetics. The contributors discuss ways that age-related epigenetic imprints such as DNA methylation and histone acetylation are modified by these two interventions. The emphasis on epigenetics helps to illuminate the underlying mechanisms of anti-ageing interventions, as ageing and disease are predominately epigenetic phenomena.
Among the highlights are chapter-length discussion of such topics as: how anti-inflammatory action of calorie restriction underlies the retardation of ageing and age-related diseases (Chapter 3); epigenetic modification of gene expression by exercise (Chapter 5); the role of functional foods and their bioactive components in bone health (Chapter 8); and an account of the first decade of a study of calorie restriction in nonhuman primates, conducted by the National Institute on Ageing.
Rezensionen / Stimmen
"This volume in the Healthy Ageing and Longevity series is a compilation of the current research highlighting the benefits of nutrition and physical activity on components of health, primarily aging. . It is appropriate for those who have a very good understanding of current research and methodology. . This book certainly has a place for researchers who wish to expand upon the growing animal model evidence of the potential benefits of nutrition and physical activity on aging." (Amy Hess-Fischl, Doody's Book Reviews, April, 2015)
Reihe
Sprache
Verlagsort
Verlagsgruppe
Springer International Publishing
Illustrationen
10 s/w Abbildungen, 13 farbige Abbildungen
VIII, 278 p. 23 illus., 13 illus. in color.
Dateigröße
ISBN-13
978-3-319-14830-4 (9783319148304)
DOI
10.1007/978-3-319-14830-4
Schweitzer Klassifikation
Preface.- Epigenetics and Nutrition.- Calorie restriction as a potent epigenetic modifier.- Anti-inflammatory action of calorie restriction for aging intervention.- Hormonal influence and modulation on aging.- Epigenetic modification by exercise.- Physiological bases and underlying mechanisms of exercise.- Sarcopenia and its intervention.- Nutritional impacts on osteopenia and osteoporosis.- Nutritional interventions for cardiac aging and age-related cardiovascular diseases.- Nutritional influence on aging brain.- Mechanistic bases of calorie restriction mimetics.- Lessons learned from calorie restricted non-human primate research.
