Analysis and Purification Methods in Combinatorial Chemistry

Preface.
Contributors.
PART I: ANALYSIS FOR FEASIBILITY AND OPTIMIZATION OF LIBRARYSYNTHESIS.
Chapter 1. Quantitative Analysis in Organic Synthesis with NMR(L. Lucas & C. Larive).
Chapter 2. ¯19F Gel-phase NMR Spectroscopy forReaction Monitoring and Quantification of Resin Loading (J.Salvino).
Chapter 3. The Application of Single-Bead FTIR and Color Testfor Reaction Monitoring and Building Block Validation inCombinatorial Library Sysnthesis(J. Cournoyer, et al.).
Chapter 4. HR-MAS NMR Analysis of Compounds Attached to PolymerSupports (M. Guinó & Y. de Miguel).
Chapter 5. Multivariate Tools for Real-Time Monitoring andOptimization of Combinatorial Materials and ProcessConditions (R. Potyrailo, et al.).
Chapter 6. Mass Spectrometry and Soluble Polymeric Supports (C.Enjalbal, et al.).
PART II: HIGH-THROUGHPUT ANALYSIS FOR LIBRARY QUALITYCONTROL.
Chapter 7. High-Throughput NMR Techniques for CombinatorialChemical Library Analysis (T. Hou & D. Raftery).
Chapter 8. Micellar Electrokinetic Chromatography as a Tool forCombinatorial Chemistry Analysis: Theory and Applications (P.Simms).
Chapter 9. Characterization of Split-Pool Encoded CombinatorialLibraries (J. Zhang & W. Fitch).
PART III: HIGH-THROUGHPUT PURIFICATION TO IMPROVE LIBRARYQUALITY.
Cha pter 10. Strategies and Methods for Purifying OrganicCompounds and Combinatorial Libraries (J. Zhao, et al.).
Chapter 11. HTP of Combinatorial Chemistry Libraries (J.Hochlowski).
Chapter 12. Practical HPLC in High Throughput Analysis andPurification (H. Gumm & R. God).
PART IV: ANALYSIS FOR COMPOUND STABILITY AND DRUGABILITY.
Chapter 13. Organic Compound Stability in Large, DiversePhatmaceutical Screening Collection (K. Morand & X. Cheng).
Chapter 14. Quartz Crystal Microbalance in BiomolecularRecognition (M. Tseng, et al.).
Chapter 15. High-Throughput Physicochemical Profiling: Potentialand Limitations (B. Faller).
Chapter 16. Solubility in the Design of Combinatorial Libraries(C. Lipinski).
Chapter 17. High-Throughput Determination of Log D Valuesby LC/MS Method (J. Villena, et al.).
Index.