1 Nicotine to Nicotinoids.- 1. Nicotine to Nicotinoids: 1962 to 1997.- 2. Nicotine and Other Insecticidal Alkaloids.- 3. Discovery of the Nitromethylene Heterocycle Insecticides.- 4. Discovery of Chloronicotinyl Insecticides.- 2 Synthetic Nicotinoid Insecticides.- 5. Chloronicotinyl Insecticides: A Success of the New Chemistry.- 6. Discovery of a New Systemic Insecticide, Nitenpyram and Its Insecticidal Properties.- 7. A Novel Insecticide, Acetamiprid.- 8. CGA 293'343: A Novel, Broad-Spectrum Neonicotinoid Insecticide.- 3 Nicotinoid Insecticide Toxicology.- 9. Imidacloprid: Toxicology and Metabolism.- 10. The Action of Nicotine in the Mammalian Brain.- 11. Nicotine Analogs: Structure-Affinity Relationships for Central Nicotinic Acetylcholinergic Receptor Binding.- 12. Managing Resistance to the Chloronicotinyl Insecticides-Rhetoric or Reality?.- 13. Structure and Function of Insect Nicotinic Acetylcholine Receptors Studied with Nicotinoid Insecticide Affinity Probes.