This work covers sequence-based protein homology detection, a fundamental and challenging bioinformatics problem with a variety of real-world applications. The text first surveys a few popular homology detection methods, such as Position-Specific Scoring Matrix (PSSM) and Hidden Markov Model (HMM) based methods, and then describes a novel Markov Random Fields (MRF) based method developed by the authors. MRF-based methods are much more sensitive than HMM- and PSSM-based methods for remote homolog detection and fold recognition, as MRFs can model long-range residue-residue interaction. The text also describes the installation, usage and result interpretation of programs implementing the MRF-based method.
Produkt-Info
Reihe
Sprache
Verlagsort
Verlagsgruppe
Springer International Publishing
Illustrationen
12
1 farbige Abbildung, 12 s/w Abbildungen
VIII, 51 p. 13 illus., 1 illus. in color.
Dateigröße
ISBN-13
978-3-319-14914-1 (9783319149141)
Schweitzer Klassifikation
