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Integral, reliable, and comprehensive guidance for chemists performing the complex syntheses required for the formation and cleavage of protective groups
Organic synthesis is the preparation and creation of organic compounds for use in natural products, pharmaceuticals, and other molecules. The synthesis of molecules having multiple functional groups often requires the use of 'protective groups' to achieve site selectivity in a chemical reaction within a molecule bearing multiple sites of reactivity. Protective groups are installed temporarily to prevent unwanted reactions at a particular site, while transforming a different functional group. Once they have served their function, they are removed to expose the original group. Without a thorough understanding of the methods required to install and remove them, the design of a synthesis of a molecule having multiple functional groups in most cases is effectively impossible.
Greene's Protective Groups in Organic Synthesis, 6th Edition is the definitive compilation of protective groups, their classification, and their application in a wide array of situations. With a long tradition of comprehensive coverage, organized on the basis of the functional group in need of protection and subsequent deprotection, it is an essential reference and resource for all chemists involved in organic syntheses. Now fully updated to reflect the current state of the art, it remains an indispensable resource for generating life-changing organic products. This edition contains a new chapter on how protective groups effect reactivity and selectivity in carbohydrate chemistry.
Readers of the sixth edition of Greene's Protective Groups in Organic Synthesis will also find:
Greene's Protective Groups in Organic Synthesis is ideal for synthetic organic chemists or medicinal chemists in academia, industry - pharmaceuticals, food, agrochemicals, and biotech - or government agencies.
Peter G. M. Wuts, PhD, is a renowned organic chemist, currently working as a chemistry consultant for both the biotech and the legal community. He continues a 50-year career in academia and the pharmaceutical industry.
In some cases, several abbreviations are used for the same protective group. We have listed the abbreviations as used by an author in his original paper, including capital and lower-case letters. Occasionally, the same abbreviation has been used for two different protective groups. This information is also included.
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