Surgical Management of Advanced Pelvic Cancer

List of Contributors viii

Preface xiii

1 From Early Pioneers to the PelvEx Collaborative 1
Éanna J. Ryan and P. Ronan O'Connell

2 The Role of the Multidisciplinary Team in the Management of Locally Advanced and Recurrent Rectal Cancer 12
Dennis P. Schaap, Joost Nederend, Harm J.T. Rutten, and Jacobus W.A. Burger

3 Preoperative Assessment of Tumor Anatomy and Surgical Resectability 17
Akash M. Mehta, David Burling, and John T. Jenkins

4 Neoadjuvant Therapy Options for Advanced Rectal Cancer 32
Alexandra Zaborowski, Paul Kelly, and Brian Bird

5 Preoperative Optimization Prior to Exenteration 45
Marta Climent and Miguel Pera

6 Patient Positioning and Surgical Technology 52
Ben Creavin, Michael E. Kelly, and Desmond C. Winter

7 Intraoperative Assessment of Resectability and Operative Strategy 62
Rory Kokelaar, Dean Harris, and Martyn Evans

8 Anterior Pelvic Exenteration 73
Jan W.A. Hagemans, Jan M. van Rees, Joost Rothbarth, Cornelis Verhoef , and Jacobus W.A. Burger

9 Posterior Pelvic Exenteration 85
Werner Hohenberger, Maximilian Brunner, and Susanne Merkel

10 Total Pelvic Exenteration 90
Satish K. Warrier, Andrew C. Lynch, and Alexander G. Heriot

11 Extended Exenterative Resections Involving Bone 97
Timothy Chittleborough, Gordon Beadel, and Frank Frizelle

12 Exenterative Resections Involving Vascular and Pelvic Sidewall Structures 110
Brian K. Bednarski and George J. Chang

13 Extended Exenterative Resections for Recurrent Neoplasm 120
Peter Sagar

14 Pelvic Exenteration in the Setting of Peritoneal Disease 127
Niels Kok, Arend Aalbers, and Geerard Beets

15 Minimally Invasive Pelvic Exenteration 132
Danielle Collins, Christos Kontovounisios, Shahnawaz Rasheed, and Paris Tekkis

16 Stoma Considerations Following Exenteration 138
Gabrielle H. van Ramshorst and Jurriaan B. Tuynman

17 Reconstructive Techniques Following Pelvic Exenteration 149
Dimitrios Patsouras, Alexis Schizas, and Mark George

18 Minimizing Morbidity from Pelvic Exenteration 158
Meara Dean, Alex Colquhoun, Peter Featherstone, Nicola S. Fearnhead, and R. Justin Davies

19 Crisis Management 170
Henrik Kidmose Christensen, Mette Møller Sørensen, and Victor Jilbert Verwaal

20 Quality of Life and Patient-Reported Outcome Measures Following Pelvic Exenteration 177
Daniel Steffens, Cherry Koh, and Michael Solomon

21 Adjuvant Therapy Options after Pelvic Exenteration for Advanced Rectal Cancer 194
Ka On Lam, Jeremy Yip, and Wai Lun Law

22 Adjuvant Therapy Options after Pelvic Exenteration for Gynecological Malignancy 205
Nisha Jagasia

23 Adjuvant Therapy Options for Urological Neoplasms 214
Gregory J. Nason, Clare O'Connell, and Paul K. Hegarty

24 The Role of Re-irradiation for Locally Recurrent Rectal Cancer 223
Johannes H.W. de Wilt and Jacobus W.A. Burger

25 Palliative Pelvic Exenteration 230
Hidde M. Kroon and Tarik Sammour

26 Outcomes of Pelvic Exenteration for Locally Advanced and Recurrent Rectal Cancer 243
Awad M. Jarrar and Scott R. Steele

27 Outcomes Following Exenteration for Urological Neoplasms 255
Frank McDermott, Ian Daniels, Neil Smart, and John McGrath

28 Outcomes Following Exenteration for Gynecological Neoplasms 265
Päivi Kannisto, Fredrik Liedberg, and Marie-Louise Lydrup

29 Mesenchymal and Non-Epithelial Tumors of the Pelvis 283
Eugenia Schwarzkopf and Patrick Boland

Index 298