Experimental and Translational Methods to Screen Drugs Effective Against Seizures and Epilepsy

Models of Seizures and Epilepsy: Important Tools in the Discovery and Evaluation of Novel Epilepsy Therapies .- Protocol for Rodent Organotypic Hippocampal Slice Culture Model for Ex Vivo Monitoring of Epileptogenesis.- Methods for the Screening of New Chemical Entities for Deciphering Neuroinflammatory and Associated Pathways in Seizures: An In Vitro Perspective.- Cellular Electrophysiological Methods to Decipher the Altered Synaptic Transmission Associated with Drug Resistant Epilepsy.- Acute Seizure Tests Used in Epilepsy Research: Step-by-Step Protocol of the Maximal Electroshock Seizure (MES) Test, The Maximal Electroshock Seizure Threshold (MEST) Test, and the Pentylenetetrazole (PTZ)-Induced Seizure Test in Rodents.- Procedures for Electrical and Chemical Kindling Models in Rats and Mice.- Methods for the Induction of status epilepticus and Temporal Lobe Epilepsy in Rodents: The Kainic Acid and the Pilocarpine Model.- Seizure Monitoring inRodents.- Protocol for 6Hz Corneal Stimulation in Rodents for Refractory Seizures.- A Method to Induce Lamotrigine-Resistant Corneal Kindled Mice.- Protocol for Drug Screening with Quantitative Video-Electroencephalography in a Translational Model of Refractory Neonatal Seizures.- Methods to Investigate Seizures and Associated Cognitive Decline using Zebrafish Model.- C. elegans as a Potential Model for Acute Seizure-Like Activity.