Mucopolysaccharides - Glycosaminoglycans - of body fluids in health and disease

Name: Mucopolysaccharides - Glycosaminoglycans - of body fluids in health and disease
Brand: De Gruyter
Price: 209.0 EUR
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Rajendra Varma Ranbir S. Varma(Autor*in)

De Gruyter (Verlag)

1. Auflage

Erschienen am 2. Januar 2012

XV, 647 Seiten

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978-3-11-150568-8 (ISBN)

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Inhalt

Intro
Preface
1. Chemistry and Metabolism of Glycosaminoglycans and Proteoglycans
1.1 Nature and classification
1.2 Modern nomenclature
1.3 Development of terminology
1.4 Other related terms in literature
1.5 Occurrence
1.6 Chemical structures
1.7 Organization as proteoglycans and aggregates
1.8 Role of silicon in molecular organization of glycosaminoglycans
1.9 Interactions with basic compounds and cations
1.10 Interaction with other macromolecules
1.11 Biosynthesis of glycosaminoglycans and proteoglycans
1.12 Degradation of proteoglycans and glycosaminoglycans
1.13 Effects of vitamins, hormones and minerals, etc
1.14 Bibliography
2. General Methods for Isolation, Fractionation and Analysis
2.1 Introduction
2.2 Isolation procedures
2.3 Fractionation of GAG mixtures
2.4 Molecular weight determination
2.5 Fractionation by preparative electrophoresis
2.6 Characterization by microscopic, optical and spectrometric methods
2.7 Analysis without hydrolysis
2.8 Analysis of components in hydrolysates
2.9 Microfractionation and microanalysis of glycosaminoglycans in mixtures
2.10 Keratan sulfate determination
2.11 Hyaluronic acid determination
2.12 Determination of dermatan and chondroitin sulfates
2.13 Bibliography
3. Biological Functions and Therapeutic Uses of Glycosaminoglycans
3.1 Introduction
3.2 Control of collagen formation and organization
3.3 Control of water in extracellular tissues
3.4 Role in urine concentrating process of kidney
3.5 Role in immunity, infection and inflammation
3.6 Role in wound healing
3.7 Role in eye
3.8 Role in central nervous system
3.9 Role in biological lubrication and biomechanics
3.10 Role in stone formation (lithiasis)
3.11 Role in hair growth
3.12 Role as ion-exchangers
3.13 Role in morphogenesis
3.14 Role in cell proliferation
3.15 Role in calcification
3.16 Therapeutic uses of glycosaminoglycans
3.17 Bibliography
4. Gastrointestinal Tract Fluids
4.1 Introduction
4.2 Methods of analysis and fractionation
4.3 Gastric juice
4.4 Intestinal fluids
4.5 Aging-related changes in gastrointestinal fluids
4.6 Gastrointestinal changes in cystic fibrosis
4.7 Bibliography
5. Glycosaminoglycans in Fluids and Fluid-Associated Tissues of the Oral Cavity
5.1 Introduction
5.2 Salivary apparatus and salivary secretion
5.3 Mucosubstances in saliva and salivary glands
5.4 Glycosaminoglycans of gingival fluid and gingiva
5.5 Glycosaminoglycans in oral cyst fluid
5.6 Relationship between dental plaque, periodontal disease and salivary flow
5.7 Age-related changes in polysaccharides of salivary glands and oral mucosa
5.8 Bibliography
6. Mucopolysaccharides in Fluids and Fluid-Associated Membranes of Respiratory Tract
6.1 Introduction
6.2 Mucus production and mucociliary function
6.3 Mucopolysaccharides in nasal secretion
6.4 Factors affecting nature and quantity of nasal secretion
6.5 Nasal secretion in cystic fibrosis
6.6 Glycosaminoglycans of nasal and paranasal mucous membranes
6.7 Acidic glycosaminoglycans in paranasal sinus mucosa
6.8 Mucopolysaccharides in nasal and paranasal carcinoma
6.9 Mucopolysaccharides of sputum
6.10 Mucopolysaccharides in bronchial secretion
6.11 Factors affecting bronchial secretion
6.12 Bibliography
7. Ocular Fluids
7.1 Introduction
7.2 Lacrimal secretion or tears
7.3 Aqueous humor
7.4 Vitreous humor
7.5 Subretinal fluid
7.6 Bibliography
8. Bile
8.1 Physiological aspects
8.2 Source and functions of bile mucins
8.3 Mucosubstances in bile
8.4 Hexuronic acid conjugates in bile
8.5 Changes in physiological and pathological states
8.6 Bibliography
9. Fluids Associated with Embryonic Membranes
9.1 Introduction
9.2 Wharton's jelly of umbilical cord
9.3 Glycosaminoglycans in Allantoic fluid
9.4 Glycosaminoglycans in eggs
9.5 Glycosaminoglycans of cardiac jelly
9.6 Bibliography
10. Glycosaminoglycans of Fluids and Fluid-Associated Tissues of Ear
10.1 General consideration
10.2 Secretion in external ear: Cerumen
10.3 Pathological middle ear fluid
10.4 Inner ear fluids: Perilymph and endolymph
10.5 Source of inner ear fluids
10.6 Glycosaminoglycans in delicate membranes of inner ear
10.7 Effects of hormones and vitamins in inner ear
10.8 Experimental studies in myxedema (hypothyroidism)
10.9 Pathological glycosaminoglycan changes in the inner ear
10.10 Role of glycosaminoglycans in inner ear function
10.11 Addendum
10.12 Bibliography
11. Amniotic Fluid (Liquor amnii)
11.1 Introduction
11.2 Origin, volume and fate of amniotic fluid
11.3 Relationship of amniotic fluid to urine
11.4 Methods of analysis and fractionation
11.5 Normal glycosaminoglycan composition
11.6 Source of glycosaminoglycans in amniotic fluid
11.7 Glycosaminoglycans variation with gestational age
11.8 Pathological changes in amniotic fluid glycosaminoglycans
11.9 Amniocentesis and intrauterine diagnosis of mucopolysaccharidoses: Problems and prospects
11.10 Bibliography
12. Synovial Fluid
12.1 Introduction
12.2 Volume and general composition
12.3 Glycosaminoglycan composition
12.4 Source of Glycosaminoglycans
12.5 Analytical and fractionation methods
12.6 Alterations in physiological and pathological states
12.7 Alterations in Viscosity
12.8 Synovial membrane in rheumatoid arthritis
12.9 Bibliography
13. Mucopolysaccharides of Physiological and Pathological Fluid Accumulations (Effusions)
13.1 Introduction
13.2 Glycosaminoglycans in extracellular fluids of tumors
13.3 Blister fluids
13.4 Cyst fluids
13.5 Glycosaminoglycans of edema fluids
13.6 Edema fluid from sexual skin
13.7 Leprous infiltrates
13.8 Mucopolysaccharides of serous effusions
13.9 Bibliography
14. Fluids of the Reproductive System
14.1 Introduction
14.2 Semen or seminal fluid
14.3 Female reproductive system
14.4 Bibliography
15. Cerebrospinal Fluid
15.1 Introduction
15.2 Location, origin and fate of CSF
15.3 Glycosaminoglycans in normal CSF
15.4 Source of CSF glycosaminoglycans
15.5 Relationship of CSF glycosaminoglycans to age
15.7 Lysosomal GAG hydrolyzing enzymes in CSF
15.8 Effects of hyaluronidase injection into CSF
15.9 Bibliography
16. Glycosaminoglycans of Blood
16.1 Introduction
16.2 Source of Plasma Glycosaminoglycans
16.3 Relationship between glycosaminoglycans in blood and urine
16.4 Methods of analysis and fractionation
16.5 Glycosaminoglycans of plasma and serum
16.6 Glycosaminoglycans of formed elements
16.7 Physiological and pathological variations in blood glycosaminoglycans
16.8 Bibliography
17. Glycosaminoglycans of Urine
17.1 Introduction
17.2 Source of urinary glycosaminoglycans
17.3 Analysis and fractionation procedures
17.4 Glycosaminoglycans of normal urine
17.5 Nondialyzable, polymeric and dialyzable, low molecular weight fractions
17.6 Relationship between plasma, urine and amniotic fluid levels
17.7 Relationship between glycosaminoglycan and 17-hydroxycorticosteroid excretion
17.8 Urinary glycosaminoglycans and renal lithiasis
17.9 Effects of physiological factors
17.10 Alterations in pathological states
17.11 Bibliography
18. Secretions of the Skin
18.1 General Views
18.2 Glycosaminoglycans in normal sweat
18.3 Glycosaminoglycans of sweat glands in pathological states
18.4 Variations with age and sex
18.5 Glycosaminoglycans in sebaceous secretions
18.6 Hormonal control of sebaceous secretion
18.7 Bibliography
19. Other Miscellaneous Body Fluids
19.1 Milk
19.2 Interstitial fluid
19.3 Lymph
19.4 Cartilage Fluid
19.5 Bibliography
Subject Index

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