While adenosine triphosphate (ATP) is described as the universal currency of energy in all living organisms at the cellular level, the actual power lies in its phosphate tail. This book is the first dedicated to the field of nucleoside triphosphate (NTP). Its 13 chapters encompass the contributions of twenty scientists from both academia and industry. It provides collective information on the chemical, physiochemical, and biological properties of both natural and modified NTP and their application in life sciences. Three chapters review families of enzymes that depend on nucleotides for assembling DNA and RNA molecules. The appendix includes supporting NMR data.
Rezensionen / Stimmen
"...the book is a clear success and represents an excellent and valuable treatise on nucleoside triphosphates. It is a must for all active chemists and researchers interested in the field of nucleoside and nucleotide analogues as potential chemotherapeutic agents. It would be a good acquisition for both personal and institutional libraries..."
-ChemBioChem, Vol. 7, No. 2, Feb. 2006
Sprache
Verlagsort
Verlagsgruppe
Zielgruppe
Für Beruf und Forschung
Organic chemists, biochemists, researchers in genomics
Illustrationen
100 s/w Abbildungen, 46 s/w Tabellen
100 b/w images and 46 tables
Dateigröße
ISBN-13
978-1-4200-2760-0 (9781420027600)
Copyright in bibliographic data and cover images is held by Nielsen Book Services Limited or by the publishers or by their respective licensors: all rights reserved.
Schweitzer Klassifikation
Chemical Synthesis of Nucleoside 5'-Triphosphate. Enzymatic Synthesis of Nucleoside Triphosphates. Synthesis and Properties of NTP Analogs with Modified Triphosphate Chains. Chemical Synthesis of Oligonuceotide Triphosphates. Solid State Structures of Nucleoside Triphosphate Metal Complexes. DNA Polymerases and Their Interactions with DNA and Nucleotides. RNA Polymerases. Reverse Transcriptases. Base-Modified Nucloside Triphosphates: Chemistry and Biological Applications. Nucleoside Triphosphate Analogs for Nonradioactive Labeling of Nucleic Acids. Antiviral Drugs: Triphosphates of Nucleoside Analogues Active as Antiviral Drugs. Other Drug Applications. Appendix: Phosphorus Nuclear Magnetic Resonance Chemical Shifts of Nucleotide Derivatives and Some Related Organophosphorus Compounds. Index
