Chemistry of Biologically Potent Natural Products and Synthetic Compounds

Name: Chemistry of Biologically Potent Natural Products and Synthetic Compounds
Brand: Wiley-ISTE
Price: 190.99 EUR
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Shahid Ul Islam Javid Ahmad Banday(Herausgeber*in)

Wiley-ISTE (Verlag)

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Erschienen am 27. April 2021

432 Seiten

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Inhalt

Cover
Half-Title Page
Series Page
Title Page
Copyright Page
Contents
Preface
1 Medicinal Importance of Plant Metabolites
1.1 Introductory Note
1.2 Primary and Secondary Metabolites
1.3 Functional Roles of Secondary Metabolites
1.4 Source and Production of Secondary Metabolites
1.5 Classification of Secondary Metabolic Substances
1.5.1 Terpenes
1.5.2 Phenol-Based Compounds
1.5.3 Nitrogen-Containing Secondary Metabolites
1.5.3.1 Alkaloids
1.5.4 Secondary Metabolites Having Sulfur
1.6 Bioactivity of Secondary Metabolites
1.6.1 As Antioxidants
1.6.2 As Antimicrobials
1.6.3 As Anti-Diabetics Agents
1.7 Conclusion and Future Perspectives
References
2 Advances in Natural Products-Based Antiviral Agents
2.1 Introduction
2.2 Anti-HIV Agents
2.2.1 Terpenes
2.2.2 Phenylpropanoids
2.2.3 Anthraquinones
2.2.4 Alkaloids
2.3 Natural Alkaloids With Activity Against HBV and HCV Infections
2.4 Anti-Influenza Virus Agents
2.5 Natural Products Active Against Herpesviruses
2.6 Natural Products Against Chikungunya Virus
2.7 Natural Products Targeting Dengue Virus
2.8 Natural Products Targeting Coronaviruses
2.9 Natural Products Against Other Viral Infections
2.10 Conclusion
Acknowledgements
References
3 Bioactive Component of Black Pepper-Piperine: Structure-Activity Relationship and Its Broad-Spectrum Activity-An Overview
List of Abbreviations
3.1 Introduction: What is a Natural Product?
3.2 Black Pepper
3.2.1 Constituents of Black Pepper
3.2.2 Major Alkaloids of Black Pepper
3.3 Piperine-Active Molecule of Pepper
3.3.1 Isolation of Piperine
3.3.2 Piperine as Potential Drug
3.3.2.1 Metabolism of Piperine
3.3.2.2 Structure-Activity Relationship
3.3.2.3 Piperine and Piperine Analogs
3.3.2.4 Synergistic Activity of Piperine
3.4 Overall Summary and Conclusion
References
4 Chemoenzymatic Synthesis of Pharmacologically Active Compounds Containing Chiral 1,2-Amino Alcohol Moiety
4.1 Introduction
4.1.1 Chirality
4.1.2 Biocatalysis
4.1.2.1 Biocatalysis is Green and Sustainable
4.1.2.2 Industrial Applications of Biocatalysts
4.1.3 Vicinal Amino Alcohols
4.2 Synthetic Approaches Toward 1,2-Amino Alcohols
4.2.1 Chemoenzymatic Synthesis of L-Norephedrine
4.2.2 Synthesis of Valinol
4.2.3 Chemoenzymatic Synthesis of Atazanavir
4.2.4 Chemoenzymatic Synthesis of Levamisole
4.2.5 Chemoenzymatic Synthesis of Optically Active (R)- and (S)-Aryloxypropanolamines
4.2.6 Chemoenzymatic Preparation of Trans-(1R,2R)- and Cis (1S,2R)-1-Amino-2-Indanol
4.2.7 Synthesis of Enantiomerically Pure 2-Aminopentane-1,3-Diol and 2-Amino-1,3,4-Butanetriol (ABT)
4.2.8 Synthesis of Optically Active Cytoxazone
4.2.9 Chemoenzymatic and Highly Integrated Synthesis of (S)-Tembamide
4.2.10 Chemoenzymatic Synthesis of Paclitaxel C¹³ Side Chain
4.3 Conclusion
Acknowledgements
References
5 1,4-Naphthoquinone: A Privileged Structural Framework in Drug Discovery
5.1 Introduction
5.1.1 Overview
5.2 Various Targets of 1,4-Naphthoquinone for Its Actions
5.2.1 Bacterial Topoisomerase II-DNA Gyrase for Antibacterial Action
5.2.2 Mammalian Topoisomerases I and II for Antitumor Action
5.2.3 HIV-1 Integrase and Proteinase for or Antiviral Action
5.2.4 Dihydroorotate Dehydrogenase for Antimalarial Action
5.2.5 Trypanothione and Trypanothione Reductase (TryR) for Leishmanicidal Action
5.2.6 Mitochondrial Cytochrome (Coenzyme Q) for Antifungal Action
5.3 Antifungal Activity
5.4 Antibacterial Activities
5.5 Anticancer Activity
5.6 Antileishmanial Activity
5.7 Antimalarial Activity
5.8 Antiviral Activity
5.9 Conclusion
Acknowledgments
References
6 Design and Synthesis of Spirobiisoxazoline Derivatives
6.1 Introduction
6.2 Literature Review on Spiroisoxazolines
6.2.1 Chemistry
6.2.2 Previous Approaches
6.2.3 Biological Importance
6.3 Literature Review on Quinones
6.3.1 Chemistry
6.3.2 Synthetic Approach
6.3.3 Biological Importance
6.4 Review on 1,3 Dipolar Cycloadditions of Oxime Chloride With Allenoates
6.5 Present Work
Spirobiisoxazoline
6.5.1 Results and Discussion
6.5.1.1 Synthetic Studies
6.5.1.2 Spectral Analysis
6.5.2 Experimental Section
6.6 Conclusion
References
7 Potential of Metal Complexes for the Treatment of Cancer: Current Update and Future Prospective
7.1 Introduction
7.2 Conclusion and Future Prospective
References
8 Design, Synthesis, and Biological Evaluation of Aziridynyl Quinone Derivatives
8.1 Introduction
8.2 Aziridines
8.2.1 Literature Review
8.2.2 Synthetic Approach
8.2.3 Biological Importance
8.3 Quinones
8.3.1 Literature Review
8.3.2 Synthetic Approach
8.3.3 Biological Importance
8.4 Aziridinyl Quinone Derivatives
8.4.1 Present Work
8.4.2 Synthetic Studies
8.4.2.1 Confirmation of Regioisomers 63 and 63a
8.4.2.2 Confirmation of Regioselectivity for Diaziridinyl Compounds
8.4.3 Biological Evaluation
8.4.3.1 Antibacterial Activity
8.4.3.2 Minimum Bactericidal Concentration
8.4.3.3 Biofilm Inhibition Assay
8.4.3.4 Antifungal Activity
8.4.3.5 Minimum Fungicidal Concentration
8.4.3.6 Cytotoxic Activity
8.4.4 Experimental Section
8.4.4.1 Chemistry
8.4.4.2 Biological Studies
8.5 Conclusion
References
9 Exploring the Promising Anticancer and Antimicrobial Potential of Bioactive Triazoles and Their Related Compounds
9.1 Introduction
9.2 Anticancer Triazole Derivatives
9.3 Antimicrobial Triazole Derivatives
9.4 Conclusion
References
10 Fused Triazolo Isoquinoline Derivatives-Design, Synthesis, and Biological Evaluation
10.1 Introduction
10.2 Literature Review on 1,2,4 Triazoles
10.2.1 Chemistry
10.2.2 Synthetic Approach
10.2.3 Biological Importance
10.3 Review on Isoquinoline and Fused Triazolo Isoquinolines
10.4 Present Work
10.5 Results and Discussion
10.5.1 Synthetic Studies
10.5.1.1 Confirmation of Regioisomer
10.5.2 Spectral Analysis
10.5.2.1 ¹H NMR Spectral and Mass Analysis
10.5.2.2 ¹³C NMR Spectral Analysis
10.5.3 Biological Studies
10.5.3.1 Antifungal Activity
10.5.3.2 Minimum Fungicidal Concentration
10.5.3.3 Ergosterol Biosynthesis Inhibition
10.5.3.4 Cytotoxic Activity
10.5.4 Molecular Docking Studies
10.5.5 Experimental Section
10.5.5.1 Chemistry
10.5.5.2 Biological Studies
10.5.6 Molecular Modeling Procedure
10.6 Conclusion
References
11 Amide as a Potential Pharmacophore for Drug Designing of Novel Anticonvulsant Compounds
11.1 Introduction
11.2 Chemistry of Amides
11.2.1 Synthesized Methods Utilized for Amide Bond Formation
11.2.2 Amide Pharmacophore Containing Anticonvulsant Drug
11.2.3 Anticonvulsant Activity
11.3 Conclusion
Acknowledgments
References
12 Nitric Oxide, Carbon Monoxide, and Hydrogen Sulfide as Biologically Important Signaling Molecules With the Significance of Their Respective Donors in Ophthalmic Diseases
12.1 Introduction
12.2 A Meaningful Introduction to Gasotransmitters
12.3 Biosynthesis and Target of NO, CO, and H²S
12.3.1 Biological Synthesis and Target of NO
12.3.2 Biological Production and Target of CO
12.3.3 Biosynthesis and Target Sites of H²S
12.4 Gasotransmitters in the Mission of Vision (Eye-Health Contribution)
12.4.1 NO News is Good News for Eyes: NO Donors for the Treatment of Eye Diseases
12.4.1.1 Nitric Oxide Releasing Molecules (NORMS) and the IOP
12.4.2 Carbon Monoxide, CORMS, and the Ocular System
12.4.3 Hydrogen Sulfide and Ophthalmic Diseases
12.5 Concluding Remarks and Future Outlook
References
13 Influence of rol Genes for Enhanced Biosynthesis of Potent Natural Products
13.1 Introduction
13.2 Secondary Metabolites or Natural Products
13.2.1 Classes of Natural Products (Secondary Metabolites)
13.2.1.1 Terpenoids
13.2.1.2 Phenolic Compounds
13.2.1.3 Alkaloids
13.2.2 Strategies to Enhance Natural Products
13.2.2.1 Plant Cell Culture (Somaclonal Variation)
13.2.2.2 Genetic Transformation of Plant Cell
13.2.2.3 Multiple Gene Transfer Through Improving Vectors
13.2.3 Genetic Engineering/Metabolic Engineering
13.3 rol Genes
13.3.1 Origin of rol Genes
13.3.2 Types of rol Genes
13.3.2.1 The rolA Gene
13.3.2.2 The rolB Gene
13.3.2.3 The rolC Gene
13.3.2.4 The rolD Gene
13.3.3 The Combined Effect of Genes rol on Secondary Metabolism
13.4 Mechanism of Action of rol Genes
13.4.1 How rol Genes Regulate ROS Production and Mediate Secondary Metabolites Production
13.4.1.1 Agrobacterium (rol Gene) and ROS
13.4.1.2 Plants Secondary Metabolism and ROS
13.4.1.3 Stabilization of Secondary Metabolites Biosynthesis Through rol Genes
13.5 Impact of rol Gene on Different Secondary Metabolites
13.5.1 Impact of rol Gene on Alkaliods
13.5.2 Impact of rol Genes on Flavonoids
13.5.3 Impact of rol Genes on Terpenoids
13.6 Conclusion
References
Index
Also Available in the "Emerging Trends in Medicinal and Pharmaceutical Chemistry" Series
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