Advances in Metallodrugs

Name: Advances in Metallodrugs | Preparation and Applications in Medicinal Chemistry
Brand: Jossey-Bass
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Preparation and Applications in Medicinal Chemistry

Shahid Ul Islam Athar Adil Hashmi Salman Ahmad Khan(Herausgeber*in)

Jossey-Bass (Verlag)

1. Auflage

Erschienen am 21. Mai 2020

432 Seiten

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978-1-119-64101-8 (ISBN)

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Inhalt

Cover
Title Page
Copyright Page
Contents
Preface
Chapter 1 Metallodrugs in Medicine: Present, Past, and Future Prospects
1.1 Introduction
1.2 Therapeutic Metallodrugs
1.2.1 Anticancer Metallodrugs
1.2.1.1 Mechanism of Anticancer Action
1.2.2 Antimicrobial and Antiviral Metallodrugs
1.2.2.1 Antimicrobial Metallodrugs
1.2.2.2 Antiviral Metallodrugs
1.2.3 Radiopharmaceuticals and Radiodiagnostic Metallodrugs
1.2.4 Anti-Diabetic Metallodrugs
1.2.5 Catalytic Metallodrugs
1.3 Future Prospects
1.4 Conclusion
References
Chapter 2 Chemotherapeutic Potential of Ruthenium Metal Complexes Incorporating Schiff Bases
2.1 Introduction
2.2 Schiff Base Complexes of Ruthenium as Anticancer Agents
2.3 Conclusion
References
Chapter 3 Role of Metallodrugs in Medicinal Inorganic Chemistry
3.1 Introduction
3.2 Platinum Anticancer Drugs
3.2.1 Nucleophilic Displacement Reactions in Complexes of Platinum
3.2.2 Mode of the Interaction of Cisplatin Species With Nitrogen Donors of DNA Strand
3.2.3 Systemic Toxicity of Cisplatin
3.3 Copper-Based Anticancer Complexes
3.3.1 Copper is Essential for Health and Nutrition
3.3.2 Healthcare Applications of Copper
3.3.3 Copper and Human Health Disorders
3.3.3.1 Wilson's Disease (WD)
3.3.3.2 Menkes' Disease
3.3.4 Role of Copper Complexes as Potential Therapeutic Agents
3.3.4.1 Thiosemicarbazones-Based Complexes
3.3.4.2 Quinolones-Based Copper Complexes
3.3.4.3 Naphthoquinones
3.4 Zinc Anticancer Complexes
3.4.1 Biologically Importance of Zinc
3.4.2 Schiff Base Chemistry
3.4.2.1 Schiff Base and Their Metal Complexes
3.4.3 Zinc-Based Complexes
3.4.4 Top Food Sources of Zinc
3.4.5 Role of Zinc in Human Body
3.4.6 Zinc as a Health Benefit
3.4.7 Zinc in Alloy and Composites
3.4.8 Zinc Supplementation as a Treatment
3.4.8.1 Zinc Deficiency
3.4.8.2 Zinc Toxicity
3.4.8.3 Zinc and Viral Infections
3.4.9 Gastrointestinal Effects
3.5 Future Prospects of Metallodrugs
References
Chapter 4 Ferrocene-Based Metallodrugs
4.1 Introduction
4.2 Ferrocene-Based Antimalarial Agents
4.2.1 Mechanism of Action
4.3 Ferrocene-Based Antibacterial and Antifungal Drugs
4.3.1 Schiff Base Derived Ferrocene Conjugates as Antibacterial Agents
4.3.2 Ferrocenyl Guanidines as Antibacterial and Antifungal Agents
4.3.3 Sedaxicene as Antifungal Agents
4.4 Ferrocene-Based Anti-Tumor and Anti-Cancerous Drugs
4.4.1 Ferricenium Salts as Anti-Tumor Agents
4.4.2 Ferrocenylalkylazoles Active Anti-Tumor Drugs
4.4.3 Ferrocene Conjugated to Peptides for Lung Cancer
4.4.4 Ferrocenylalkyl Nucleobases Potential Anti-Cancerous Drugs
4.4.5 Ferrocenyl Sub-Ordinates of Illudin-M
4.4.6 Ferrocenyl Derivatives of Retinoids Potential Anti-Tumor Drug
4.4.7 Targeting Breast Cancer With Selective Ferrocene-Based Estrogen Receptor Modulators (SERM)
4.5 Conclusion
4.6 Future of Ferrocene-Based Drugs
References
Chapter 5 Recent Advances in Cobalt Derived Complexes as Potential Therapeutic Agents
5.1 Introduction
5.2 Cobalt Complexes as Potential Therapeutic Agents
5.3 Conclusion
References
Chapter 6 NO-, CO-, and H2S-Based Metallopharmaceuticals
6.1 Introduction
6.2 Signaling Molecules: Concept of "Gasotransmitter"
6.2.1 Therapeutic Applications of NO, CO, and H2S
6.2.1.1 Exogenous NO Donating Molecules
6.3 NO Donors Incorporated in Polymeric Matrices
6.3.1 Metal Nitrosyl Complexes
6.3.1.1 Sodium Nitroprusside (SNP)
6.4 Dinitrosyl Iron Thiol Complexes (DNICs)
6.5 Photoactive Transition Metal Nitrosyls as NO Donors
6.6 Exogenous CO Donating Molecules
6.7 H2S Donating Compounds
6.7.1 H2S Gas: A Fast Delivering Compound
6.7.2 Sulfide Salts: Fast Delivering H2S Compounds
6.7.3 Synthetic Moieties
6.7.3.1 Slow-Delivering H2S Compounds
6.7.3.2 H2S-Releasing Composite Compounds
6.7.4 Naturally Occurring Plant Derived Compounds
6.7.4.1 Garlic
6.7.4.2 Broccoli and Other Cruciferous Vegetables
6.8 Concluding Remarks and Future Outlook
References
Chapter 7 Platinum Complexes in Medicine and in the Treatment of Cancer
7.1 What is Cancer?
7.1.1 Characteristic Features of Cancer Cells
7.1.2 Definition of Anticancer Compound
7.1.3 Anticancer Attributes of Pt Complexes
7.1.4 Native State Behavior of Pt Complexes
7.2 Compatibility of Pt Compounds in Cancer Treatment
7.2.1 Significance of DNA as Primary Target
7.2.2 Kinetics of DNA Binding Activities
7.2.3 Structural and Regioselectivity of DNA Adducts
7.2.4 Studies on Action Mechanism
7.3 Pt Complexes as Anticancer Drugs
7.3.1 DNA-Coordinating Pt(II) Complexes
7.3.2 DNA-Covalently Binding Pt(II) Complexes
7.3.3 Targeted Pt(II) Complexes
7.3.4 Pt(IV) Prodrugs
7.3.5 Multiple Action of Pt(IV) Prodrugs
7.3.6 Targeted Pt(IV) Prodrugs
7.3.7 Photodynamic Killing of Cancer Cell by Pt Complexes
7.4 Conclusion
Acknowledgments
References
Chapter 8 Recent Advances in Gold Complexes as Anticancer Agents
8.1 Introduction
8.2 Evolution of Metal Complexes as Anticancer Agents
8.3 Gold Complexes
8.3.1 Complexes with Nitrogen Donar Ligands
8.3.2 Complexes with Sulphur Donar Ligands
8.3.3 Complexes with Phosphorus Donar Ligands
8.3.4 Complexes with Sulphur-Phosphorus Donar Ligands
8.3.5 Organometallic Gold Complexes
8.3.6 Miscellaneous
8.4 Nano-Formulations of Gold Complexes
8.5 Future Challenges and Perspectives
8.6 Conclusion
Acknowledgements
References
Chapter 9 Recent Developments in Small Molecular HIV-1 and Hepatitis B Virus RNase H Inhibitors
9.1 Introduction
9.1.1 Activity and Function of HIV and HBV RNases H
9.1.2 The Metal-Chelating RNase H Active Site
9.2 RNase H Inhibitors and Strategies in the Discovery of Active Compounds
9.2.1 High-Throughput Screening
9.2.2 Design Based on Pharmacophore Models
9.2.3 Novel Inhibitors Obtained by Using "Click Chemistry"
9.2.4 Dual-Target Inhibitors Against HIV-1 Integrase (IN) and RNase H
9.2.5 Inhibitors Obtained by Using Privileged Fragment-Based Libraries
9.2.6 RNase H Inhibitors in Natural Products
9.2.7 Drug Repurposing Based on Privileged Structures
9.3 Conclusion
References
Chapter 10 The Role of Metals and Metallodrugs in the Modulation of Angiogenesis
10.1 Introduction
10.2 Metallodrugs in Anticancer Therapy
10.3 Angiogenesis as a Substantial Target of Tumorigenesis
10.4 Metals and Metallodrugs in Angiogenesis
10.5 Concluding Remarks and Future Prospects
References
Chapter 11 Metal-Based Cellulose: An Attractive Approach Towards Biomedicine Applications
11.1 Introduction
11.2 History of Cellulose
11.3 The Properties and Structure of Cellulose
11.4 Modification of Cellulose
11.4.1 Acid Hydrolysis
11.4.2 Oxidation
11.4.3 Esterification
11.4.4 Amidation
11.4.5 Carbamiation
11.4.6 Etherification
11.4.7 Nucleophilic Substitution
11.4.8 Further Modification
11.5 Present and Future Medical Applications of Cellulose as Well as Its Components
11.5.1 Cellulose Used as Wound Dressing
11.5.2 Dental Applications
11.5.3 Engineering
11.5.4 Controllable Drug Delivery System
11.5.5 Blood Purification
11.5.6 Wrapping Purpose
11.5.7 Renal Failure
11.6 Conclusion
References
Chapter 12 Multifunctional Nanomedicine
12.1 Introduction
12.2 Diagnostics and Imaging
12.3 Drug Delivery and Therapy
12.3.1 Drug Delivery by Organic Nanomaterials
12.3.1.1 Liposomal Drug Delivery
12.3.1.2 Polymeric Drug Delivery
12.3.1.3 Proteins and Peptides for Drug Delivery
12.3.2 Drug Delivery by Inorganic Nanomaterials
12.3.2.1 Metal and Metal Oxides
12.3.2.2 Au NPs
12.3.2.3 Carbon-Based NPs
12.3.2.4 Silicon-Based Nanostructures for Drug Delivery
12.3.3 Photo Therapy
12.3.3.1 Photodynamic Therapy
12.3.3.2 Photothermal Therapy
12.3.4 Radiation Therapy
12.3.5 Neutron Capture Therapy
12.4 Regenerative Medicine
12.5 Future Prospects and Conclusion
References
Index
EULA

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