Adverse Drug Reactions

Target Organ Toxicity.- Drug-Induced Liver Injury.- Drug Hypersensitivity Reactions Involving Skin.- Adverse Drug Reactions Affecting Blood Cells.- Molecular Mechanisms of Adverse Drug Reactions in Cardiac Tissue.- Mechanisms of Drug-Induced Nephrotoxicity.- Receptor- and Reactive Intermediate-Mediated Mechanisms of Teratogenesis.- Mediators/Biochemical Pathways.- Role of Reactive Metabolites in Drug-Induced Hepatotoxicity.- The Role of Cytokines in the Mechanism of Adverse Drug Reactions.- The Keap1-Nrf2 Cellular Defense Pathway: Mechanisms of Regulation and Role in Protection Against Drug-Induced Toxicity.- Signal Transduction Pathways Involved in Drug-Induced Liver Injury.- Mitochondrial Involvement in Drug-Induced Liver Injury.- Examples/Models.- Mechanisms of Acetaminophen-Induced Liver Necrosis.- Drug-Induced Liver Injury in Humans: The Case of Ximelagatran.- Troglitazone.- Nevirapine Hypersensitivity.- Mechanisms of Adverse Drug Reactions to Biologics.- Risk Factors/Screening Drug Candidates.- Pharmacogenetics of Idiosyncratic Adverse Drug Reactions.- The Danger Hypothesis Applied to Idiosyncratic Drug Reactions.- Approaches for Minimizing Metabolic Activation of New Drug Candidates in Drug Discovery.