Adverse Drug Reactions

Part I. Target Organ Toxicity.- Drug-Induced Liver Injury. Drug Hypersensitivity Reactions Involving Skin. Adverse Drug Reactions Affecting Blood Cells. Molecular Mechanisms of Adverse Drug. Reactions in Cardiac Tissue. Nephrotoxicity Receptor- and Reactive Intermediate-Mediated Mechanisms of Teratogenesis.- Part II. Mediators/Biochemical Pathways.- Role of Reactive Metabolites in Drug-Induced Hepatotoxicity. The Role of Cytokines in the Mechanism of Adverse Drug Reactions. The Keap1-Nrf2 Cellular Defence Pathway. Signal Transduction Pathways Involved in Drug-Induced Liver Injury. Mitochondrial Involvement in Drug-Induced Liver Injury.- Part III. Examples/Models.- Mechanisms of Acetaminophen-Induced. Liver Necrosis. Drug-Induced Liver Injury in Humans: The Case of Ximelagatran. Troglitazone. Nevirapine Hypersensitivity. Mechanisms of Adverse Drug Reactions to Biologics.- Part IV. Risk Factors/Screening Drug Candidates.- Pharmacogenetics of Idiosyncratic Adverse Drug Reactions. The Danger Hypothesis Applied to Idiosyncratic Drug Reactions. Approaches for Minimizing Metabolic Activation of New Drug Candidates in Drug Discovery.