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This new and updated edition provides an extensive overview of the antibodies employed in diagnostic tumor histopathology, and it presents concise summaries of the immunoprofiles of most tumors. Additionally, it offers practical diagnostic algorithms and invaluable tips to facilitate the interpretation of results.
The work includes the newest available antibodies and the most recent 5th edition of the WHO classification of tumors. Furthermore, a chapter on biomarkers for theranostic applications has been added to enhance the book's utility.
Designed as a practical and user-friendly bench reference for diagnostic tumor histopathology, this book is recommended to histopathologists of all levels, from aspiring residents to seasoned specialists seeking a reliable and comprehensive resource for tumor diagnostics. Moreover, it is highly recommended for oncologists, hematologists, and researchers involved in these fields.
Doctor Muin S.A. Tuffaha In 1986, Dr. Tuffaha achieved the MD degree in General Medicine with honors from the Medical Institute Kiev, USSR. 1993 he passed the German Board in Pathology and continued as a specialist in pathology at the Institute of Pathology, Faculty of Medicine of the Technical University Dresden. In 1995, he became the Deputy Head of the Department of Head and Neck Pathology at the University of Hamburg. In 2003, he attained a subspecialty in molecular pathology.
Since 2010, Dr. Tuffaha has been the Head of the Institute of Pathology at the Carl-Thiem Teaching Hospital affiliated with the Medical Faculty Charité Berlin. Additionally, he received an honorary Professorship from the Kiev Medical University of UAFM.
Professor Hans Guski was appointed full professor of pathology in 1994 and was deputy director and prosector of the Institute of Pathology of the Medical Faculty (Charité) of the Humboldt University in Berlin. He was author or co-author of more than 300 scientific publications and mentor to almost 80 doctoral students from Germany and abroad (Angola, Congo, Cuba, Jordan, Syria, Mongolia, USSR and Russia respectively). In 1996 he received an honorary doctorate (Dr. h. c.) from the University of Saransk, Russia, and in 2004 a guest professorship from the University of Havana, Cuba. After leaving the Institute of Pathology at the Charité in 2005, he continued to work in various clinics, and from 2016 to now at the Vivantes Klinikum Berlin Neukölln as diagnostic pathologist, prosector and mentor of young residents and doctoral students.
Introduction.- Chapter 1. Immunohistochemistry in tumor diagnosis.- Chapter 2. Immunohistochemical markers for the diagnosis of epithelial tumors.- Chapter 3. Markers and immunoprofile of pulmonary tumors and tumors of upper respiratory tract, middle and inner ear.- Chapter 4. Markers and immunoprofile of thymic epithelial tumors.- Chapter 5. Markers and immunoprofile of heart and pericardial tumors.- Chapter 6. Markers and immunoprofile of tumors of the oral cavity, oropharynx and salivary glands.- Chapter 7. Markers and immunoprofile of tumors of the gastrointestinal tract.- Chapter 8. Markers and immunoprofile of pancreatic tumors.- Chapter 9. Markers and immunoprofile of hepatobiliary tumors.- Chapter 10. Markers and immunoprofile of breast tumors.- Chapter 11. Markers and immunoprofile of tumors of female reproductive organs.- Chapter 12. Markers and immunoprofile of renal and urinary tract tumors.- Chapter 13. Markers and immunoprofile of male genital tract tumors.- Chapter 14. Markers and immunoprofile of tumors of endocrine organs and neuroendocrine tumors.- Chapter 15. Markers and immunoprofile of mesothelioma and tumors of the peritoneum.- Chapter 16. Markers and immunoprofile of lymphoid neoplasms.- Chapter 17. Markers and immunoprofile of myeloid neoplasms.- Chapter 18. Markers and immunoprofile of mastocytosis.- Chapter 19. Markers and immunoprofile of histiocytic and dendritic cell neoplasms.- Chapter 20. Markers and immunoprofile of stroma-derived neoplasms of lymphoid tissues.- Chapter 21. Markers and immunoprofile of skin tumors.- Chapter 22. Markers and immunoprofile of melanocytic tumors.- Chapter 23. Markers and immunoprofile of fibroblastic, myofibroblastic and fibrohistiocytic tumors.- Chapter 24. Markers and immunoprofile of muscle tumors.- Chapter 25. Markers and immunoprofile of vascular and pericytic (perivascular) tumors.- Chapter 26. Markers and immunoprofile of adipocytic tumors.- Chapter 27. Markers and immunoprofile of peripheral nerve- and nerve sheet tumors.- Chapter 28. Markers and immunoprofile of the central nervous system tumors.- Chapter 29. Markers and immunoprofile of Ewing sarcoma / primitive neuroectodermal tumors (PNET) and Ewing sarcoma-like tumors.- Chapter 30. Markers and immunoprofile of extraskeletal osseous and cartilaginous tumors.- Chapter 31. Markers and immunoprofile of miscellaneous tumors and tumors of uncertain differentiation.- Chapter 32. Immunohistochemistry and biomarkers for targeted tumor therapy.- Chapter 33. Markers to assist in the diagnosis of dysplasia and malignant transformation.- Chapter 34. Recommendations for the utility of immunohistochemical results in tumor diagnosis.
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