Applications of Microdialysis in Pharmaceutical Science

Discover new and emerging applications for microdialysis in drugevaluation
Microdialysis is a highly valuable sampling tool that can beused in vivo to measure free, unbound analyte concentrationslocated in interstitial and extracellular spaces. This bookexplores the full range of clinical applications for microdialysis,focusing on its use in different organ and tissue systems forpharmacokinetic and pharmacodynamic studies. Readers gain a fullunderstanding of the underlying science of microdialysis, currenttechniques and practices, as well as its many applications inpharmaceutical research.
Applications of Microdialysis in Pharmaceutical Science startswith an introduction to basic principles and then covers analyticalconsiderations, pharmacodynamic and pharmacokinetic studies,clinical aspects, and special applications. Topics include:
* Role of microdialysis in drug development, including crucialsampling considerations and applications for nervous systemdiseases
* Continuous measurement of glucose concentrations indiabetics
* Applications for clinical evaluation and basic research on organsystems, including monitoring exogenous and endogenous compounds inthe lungs
* Pharmacokinetic and pharmacodynamic evaluation of anticancerdrugs
* Comparison of microdialysis with imaging approaches to evaluatein vivo drug distribution
* Special applications of microdialysis in studies of cell cultureassays, drug-drug interactions, and environmental monitoring
Throughout the book, readers will find simple models thatclarify complex concepts and easy-to-follow examples that guidethem through key applications in pharmaceutical research. In short,this book enables pharmaceutical researchers to take full advantageof microdialysis techniques for the preclinical and clinicalevaluation of drugs and much more.