Microglia

PART I: Introduction.- Chapter 1: General Pathophysiology of Microglia.- Chapter 2: History of Microglia.- Chapter 3: Evolution of Microglia.- Chapter 4: Visualization, Fate Mapping, Ablation and Mutagenesis of Microglia in the Mouse Brain.- Chapter 5: Technological Innovations: Progress of the Structural and Functional in vivo Imaging of Microglia.- PART II: Basic Discoveries in Physiology.- Chapter 6:Microglial Physiology: Receptors.- Chapter 7: Microglial Physiology: Calcium Signalling.- Chapter 8:Contactomics of Microglia and Intercellular Communication.- Chapter 9: Elimination of Neurones: Embryonic and Postnatal Development.- Chapter 10: Developmental Angiogenesis, Astrogliogenesis, and Myelination.- Chapter 11: Synaptic Formation and Elimination.- Chapter 12: Synaptic Maturation, Activity, and Plasticity.- Chapter 13: Adult Neurogenesis, Learning and Memory.- Chapter 14: Regulation of Sleep and Wakefulness.- PART III: General Pathophysiology of Microglia.- Chapter 15: Roles in Innate Immunity.- Chapter 16: Microglia and Systemic Immunity.- Chapter 17: Microglia and Microbiome-Gut-Brain Axis.- Chapter 18: Stress and Microglia: A Double-Edged Relationship.- Chapter 19: Substance Use and Addiction.- Chapter 20: Microglia and Sleep Disorders.- Chapter 21: Ageing.- Part IV: Microglia and Pathophysiology of Diseases of Nervous System.- Chapter 22: Neuropathic Pain.- Chapter 23: Role of Microglia in Stroke.- Chapter 24: Infectious Diseases including COVID-19 and HAND.- Chapter 25: Microglia and Multiple Sclerosis.- Chapter 26: Neurodevelopmental and Neuropsychiatric Disorders.- Chapter 27: Neurodegenerative Diseases.- Chapter 28: Microglia in Glioma.- PART V: Clinical Potential.- Chapter 29: Microglial Risk Alleles for Neurodegenerative Diseases (GWAS studies).- Chapter 30: Emerging Models for the Study of Human Microglia in vitro (e.g. IPSCs, minibrains).- Chapter 31: Emerging Models for the Study of Human Microglia ex vivo (comparison between human and rodent microglia).- Chapter 32: Radiotracers for Microglial PET Imaging in vivo (focus on TSPO and its limitations).- Chapter 33: Role of Microglial Modulation in Therapies for Perinatal Brain Injuries Leading to Neurodevelopmental Disorders.- Chapter 34: Metabolic Control of Microglial Function.- Chapter 35: Microglial Emerging Therapies and Targets under Clinical Trial.- Chapter 36: Epilogue.