This volume provides current methods to analyze the properties of designer receptors exclusively activated by designer drugs (DREADDs) in vitro and to measure the biological responses of DREADD activation in different neuronal populations in vivo. Chapters focus on the utility of DREADD technology to selectively stimulate or inhibit neuronal activity in selected brain areas of transgenic mice. In addition, the successful use of DREADD expression in rats and Drosophila is described. Together, the DREADD technology represents a non-invasive, chemical-genetic tool for investigating neuronal signaling and the resulting behavioural responses in vivo. Written in the popular
Neuromethods
series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your own laboratory. Concise and easy-to-use,
Designer Receptors Exclusively Activated by Designer Drugs
aims to ensure successful results in the further study of this vital field.
Reihe
Auflage
Sprache
Verlagsort
Verlagsgruppe
Illustrationen
14
14 s/w Abbildungen, 14 farbige Abbildungen
XVII, 160 p. 28 illus., 14 illus. in color.
Dateigröße
ISBN-13
978-1-4939-2944-3 (9781493929443)
DOI
10.1007/978-1-4939-2944-3
Schweitzer Klassifikation
