This book deals with the mechanisms through which glutamate, the principal excitatory neurotransmitter in the mammalian central nervous system, modifies neuronal membrane functions and intraneuronal functions. Discussed are the hypothesis that the glutamate receptor signal may be processed by archidonic acid, nitric oxide, Ca 2+ and protein kinases. A key routefor glutamate receptors in synaptic plasticity and neuronal degeneration is beeing increasingly recognized. This is one of the most important new areas of endeavor by neurobiologists. The book, written by some of the most wellknown scientists in this field, provides a comprehensive reviewof conceptual approaches along with experiments showing a link between excitation mediated by glutamate and second messenger systems.
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ISBN-13
978-3-662-22666-7 (9783662226667)
DOI
10.1007/978-3-662-22666-7
Schweitzer Klassifikation
1 Diversity and Organization of Excitatory Amino Acid Receptors in the CNS.- 2 Molecular Biology of Glutamate-Gated Channels: Focus on AMPA and Kainate.- 3 From Excitatory Amino Acid Receptors to Long-Term Potentiation: An Insight into the Role of Ca2+.- 4 Evidence that Arachidonic Acid Plays a Role in Long-Term Potentiation.- 5 Glutamate Release by Reversed Glutamate Uptake Is Inhibited by Arachidonic Acid.- 6 Intracellular and Intercellular Messengers Produced by Metabotropic (Qp), AMPA, and NMDA Excitatory Amino Acid Receptors.- 7 Glutamate Receptors, Nitric Oxide, and Cyclic GMP.- 8 Nitric Oxide: A Messenger of Cerebellar Granule Cells.- 9 Protein Dephosphorylation as a Mediator of NMDA Receptor Signal Transduction.- 10 Phosphoinositide-Linked Glutamate Receptors: Prominent Actions in Neurons and Glia.- 11 Neuromodulation of Non-NMDA Class Glutamate Receptor Channels in Hippocampal Neurons.- 12 Regulation of Glial Kainate Receptor Function by Extracellular Ligands and Intracellular Messengers.
