Biocatalysis for Green Chemistry and Chemical Process Development

Contributors vii
Preface xi
Part I. Introduction Chapters 1
1. Biotechnology Tools for Green Synthesis: Enzymes, MetabolicPathways, and Their Improvement by Engineering 3
2. How Green Can the Industry Become with Biotechnology? 23
3. Emerging Enzymes and Their Synthetic Applications 45
4. Reaction Efficiencies and Green Chemistry Metrics ofBiotransformations 67
Part II. Application and Case Studies-Pharmaceuticals andFine Chemicals 89
5. Biocatalytic Routes to Chiral Intermediates for Developmentof Drugs 91
6. Transglutaminase for Protein Drug Modification: Pegylationand Beyond 151
7. Microbial Production of Plant-Derived Pharmaceutical NaturalProducts Through Metabolic Engineering: Artemisinin and Beyond173
8. Toward Greener Therapeutic Proteins 197
Part III. Application and Case Studies-Flavor &Fragrance, Agrochemicals and Fine Chemicals 221
9. Opportunities for Biocatalysis in the Flavor, Fragrance, andCosmetic Industry 223
10. Application of Biocatalysis in the Agrochemical Industry255
11. Green Porduction of Fine Chemicals by Isolated Enzymes277
12. Whole Cell Production of Fine Chemicals and Intermediates299
Part IV. Application and Case Studies-Polymers and RenewableChemicals 327
13. Green Chemistry for the Production of Biodegradable,Biorenewable, Biocompatible, and Polymers 329
14. Enzymatic Degradation of Lignocellulosic Biomass 361
15. Bioconversion of Nenewables-Plant Oils 391
16. Microbial Bioprocesses for industrial-Scale ChemicalProduction 429
Index 469