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Absorption, Distribution, Metabolism and Excretion (ADME) processes and their relationship with the design of dosage forms and the success of pharmacotherapy form the basis of this upper level undergraduate/graduate textbook. As an introduction oriented to pharmacy students, it is also written for scientist from different fields outside of pharmaceutics. (e.g. material scientist, material engineers, medicinal chemists) who might be working in a positions in pharmaceutical companies or whose work might benefit from basic training in the ADME concepts and some biological background.
Pedagogical features such as objectives, keywords, discussion questions, summaries and case studies add valuable teaching tools. This book will provide not only general knowledge on ADME processes but also an updated insight on some hot topics such as drug transporters, multi-drug resistance related to pharmacokinetic phenomena, last generation pharmaceutical carriers (nanopharmaceuticals), invitro and in vivo bioequivalence studies, biopharmaceuticals, pharmacogenomics, drug-drug and food-drug interactions, and in silico and in vitro prediction of ADME properties. In comparison with other similar textbooks, around half of the volume would be focused on the relationship between expanding scientific fields and ADME processes. Each of these burgeoning fields has a separate chapter in the second part of the volume, and was written with leading experts on the correspondent topic, including scientists and academics from USA and UK (Duquesne University School of Pharmacy, Indiana University School of Medicine, University of Utah College of Pharmacy, University of Maryland, University of Bath).
Additionally, each of the initial chapters dealing with the generalities of drug absorption, distribution, metabolism and excretion would include relevant, classic examples related to each topic with appropriate illustrations (e.g. importance of active absorption of levodopa, implications in levodopa administration, drug drug interactions and food drug interactions emerging from the active uptake; intoxication with paracetamol as a result of glutathione depletion, CYP induction and its relationship with acute liver failure caused by paracetamol, etc).
ADME Processes and Pharmaceutical Sciences is written as a core textbook for ADME processes, pharmacy, pharmacokinetics, drug delivery, biopharmaceutics, drug disposition, drug design and medicinal chemistry courses.
Prof. Alan Talevi obtained his Pharmacy degree in 2004 and completed his PhD studies in 2007, both at the University of La Plata. He obtained the award for the best PhD thesis from the Argentinean Chemical Society (2008) and the Award to Scientific, Technological an Artistic Production from the National University of La Plata (2016). He holds a permanent position at the Argentinean National Council of Scientific and Technical Research since 2010, and he is the professor in charge of the Biopharmacy course at the Faculty of Exact Sciences, University of La Plata, since 2012. He has published over 50 articles in periodicals and more than 20 book chapters, mostly in the fields of rational drug discovery and biopharmacy. He was elected Head of the Department of Biological Sciences of the Faculty of Exact Sciences, University of La Plata, between 2015 and 2017. In 2018 he became the Head of the Laboratory of Bioactive Research and Development (LIDeB, University of La Plata). External reviewer for several agencies and universities, including Argentinean National Agency of Scientific and Technical Promotion, Argentinean Ministry of National Education, the National Agency for Evaluation and Forecasting (Spain), University of La República (Uruguay) and the National Agency of Scientific and Technical Promotion (Uruguay). Reviewer of more than 60 periodicals, including Current Drug Delivery, PLoS One, Expert Opinion on Drug Delivery, ChemMedChem, European Journal of Medicinal Chemistry, European Journal of Pharmacology, International Journal of Pharmaceutics, Journal of Pharmacy and Pharmacology, Journal of of Materials Chemistry B, Drug Delivery and Expert Opinion on Drug Discovery. Member of the editorial board of the Latin American Journal of Pharmacy (from 2014 and continues). Guest editor of Mini-Reviews in Medicinal Chemistry and Current Drug Safety. Editor of the Antiepileptic Drug Discovery Novel Approaches volumen of the Springer Protocols series (2016) andBiopharmaceutical processes (University of La Plata Publishing, 2016). He has taught several PhD courses and postgraduate courses in Argentina, Uruguay and Mexico. He currently studies Artistic Writing at the National Arts University (Argentina). In 2016 and 2017 he received literary awards from Itaú Fundation.
Pablo Alejandro Mauricio Quiroga is a Pharmacist and has Bachelor in Pharmaceutical Sciences from the Faculty of Exact Sciences of the University of La Plata (UNLP). University Expert in Toxicology and Master of Science in Toxicology of the University of Seville, Spain. He is a Full Professor of the Chairs of Quality Control of Drugs and Pharmaceutical Toxicology of the Faculty of Exact Sciences of the UNLP. Chief of Pharmacological Research Department - Laboratorios Bagó S.A. Member of the Council of Experts of Argentinean Pharmacopoeia. Co- Editor of The E-Books: Pharmaceutical Analysis (2013), and Biopharmaceutical Processes (2016)- University of La Plata Publishing - EDULP. Co-author of several scientific publications. External reviewer of the UBACYT 2014-2017 Research Projects-UBA (University of Buenos Aires). Member of American Association of Pharmaceutical Scientists (AAPS) and the Argentinean Association of Industrial Pharmacy and Biochemistry (SAFYBI). Workshop Co-Chairs and Speaker "Implementation of Biowaivers based on the Biopharmaceutics Classification System"- held by the Focus Group on Biopharmaceuticals Classification System (BCS) and Biowaivers -International Pharmaceutical Federation (FIP) and Faculty of Exact Sciences - UNLP. Workshop Member of the Organizing Committee of "Dissolution Testing and Bioequivalence" held by American Association of Pharmaceutical Scientists (AAPS) and Faculty of Exact Sciences - UNLP.
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