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Absorption, Distribution, Metabolism and Excretion (ADME) processes and their relationship with the design of dosage forms and the success of pharmacotherapy form the basis of this upper level undergraduate/graduate textbook. Whereas primarily oriented to Pharmacy students and graduates, it can also be useful for scientist from different fields elated to pharmaceutics and pharmacology. (e.g., material scientists, material engineers, medicinal chemists, physicians) who might be working in a positions in pharmaceutical companies or whose work might benefit from basic training in the ADME concepts and related biological background.
Pedagogical features such as objectives, keywords, discussion questions, summaries and case studies are included as teaching tools. This book will provide not only general knowledge on ADME processes but also an updated insight on some hot topics such as drug transporters, multi-drug resistance related to pharmacokinetic phenomena, last generation pharmaceutical carriers (nanopharmaceuticals), in vitro and in vivo bioequivalence studies, biopharmaceuticals, pharmacogenomics, drug-drug and food-drug interactions, in silico and in vitro prediction of ADME properties, or chronopharmacokinetic. In comparison with other similar textbooks, around half of the volume would be focused on the relationship between expanding scientific fields and ADME processes. Each of these burgeoning fields has a separate chapter in the second part of the volume, and is written with experts on the correspondent topic, including industrial scientists and academics from USA and UK.
Additionally, each of the initial chapters dealing with the generalities of drug absorption, distribution, metabolism and excretion would include relevant, classic examples related to each topic with appropriate illustrations.
ADME Processes and Pharmaceutical Sciences is written as a core textbook for courses on pharmaceutical sciences: pharmacology, pharmacokinetics,drug delivery, biopharmaceutics, drug design and medicinal chemistry courses.
Prof. Alan Talevi obtained his Pharmacy degree in 2004 and completed his PhD studies in 2007, both at the University of La Plata. He obtained the award for the best PhD thesis from the Argentinean Chemical Society (2008) and the Award to Scientific Production from the National University of La Plata (2016). He holds a permanent position at the Argentinean National Council of Scientific and Technical Research since 2010, and he is Full Professor of the Biopharmacy course at the Faculty of Exact Sciences, University of La Plata. He has published over 100 articles in periodicals and more than 50 book chapters and entries, mostly in the fields of drug discovery and pharmacokinetics. He was elected Head of the Department of Biological Sciences of the Faculty of Exact Sciences, University of La Plata, between 2015 and 2017. In 2018 he became the Head of the Laboratory of Bioactive Compound Research and Development (LIDeB, University of La Plata). External reviewer for several agencies and universities, including Argentinean National Agency of Scientific and Technical Promotion, the United Nations University, the National Science Center (Poland), KU Leuven (Belgium), CONCYTEC (Perú), UK Research and Innovation (UK). Argentinean Ministry of National Education, University of La República (Uruguay), National Agency of Scientific and Technical Promotion (Uruguay). Reviewer of more than 80 periodicals, including Nature Communications, Scientific Reports, Journal of Medicinal Chemistry, Journal of Chemical Information and Modelling, Journal of Molecular Graphics and Modelling, PLoS One, Expert Opinion on Drug Delivery, Expert Opinion on Drug Discovery, Expert Opinion on Drug Metabolism and Toxicology, European Journal of Medicinal Chemistry, European Journal of Pharmacology, International Journal of Pharmaceutics. Member of the editorial board of Current Therapeutic Research (2023 and continues) and the Latin American Journal of Pharmacy (2014 and continues). Associateeditor for Frontiers in Natural Products (2023 and continues). Reviewing editor for eLife (2022 and continues). Guest editor of Mini-Reviews in Medicinal Chemistry, Current Drug Safety, and Frontiers in Chemistry. Editor of the ADME Encyclopedia (Major Reference Works, Springer Nature, 2022), Antiepileptic Drug Discovery Novel Approaches volume (Springer Protocols series, 2016) and Biopharmaceutical processes (University of La Plata Publishing, 2016), among others. He has taught several PhD courses and postgraduate courses in Argentina, Uruguay, Mexico, Ecuador and Perú, and he has acted as invited lecturer at Universidad Autonoma de México, Universidad de Guadalajara (México) and Universidad de Salamanca (Spain), among others.
Pablo Quiroga is a Pharmacist and has Bachelor in Pharmaceutical Sciences from the Faculty of Exact Sciences of the University of La Plata (UNLP). University Expert in Toxicology and Master of Science in Toxicology of the University of Seville, Spain. He is a Full Professor of the Chairs of Quality Control of Drugs and Pharmaceutical Toxicology of the Faculty of Exact Sciences of the UNLP. Chief of Pharmacological Research Department - Laboratorios Bagó S.A. Member of the Council of Experts of Argentinean Pharmacopoeia. Co- Editor of The E-Books: Pharmaceutical Analysis (2013), and Biopharmaceutical Processes (2016)- University of La Plata Publishing - EDULP. Co-author of several scientific publications. External reviewer of the UBACYT 2014-2017 Research Projects-UBA (University of Buenos Aires). Member of American Association of Pharmaceutical Scientists (AAPS) and the Argentinean Association of Industrial Pharmacy and Biochemistry (SAFYBI). Workshop Co-Chairs and Speaker "Implementation of Biowaivers based on the Biopharmaceutics Classification System"- held by the Focus Group on Biopharmaceuticals Classification System (BCS) and Biowaivers -International Pharmaceutical Federation (FIP) and Faculty of ExactSciences - UNLP. Workshop Member of the Organizing Committee of "Dissolution Testing and Bioequivalence" held by American Association of Pharmaceutical Scientists (AAPS) and Faculty of Exact Sciences - UNLP. He is a member of the Argentinean National Academy of Pharmacy and Biochemistry.
Part 1: The basics of ADME processes.- Chapter 1-Introduction. Biopharmaceutics and Pharmacokinetics.- Chapter 2-Drug release.- Chapter 3-Drug Absorption.- Chapter 4-Drug Distribution.- Chapter 5-Drug Metabolism.- Chapter 6-Drug Excretion.- Chapter 7-Drug Delivery Routes.- Chapter 8-Compartmental Pharmacokinetic Models.- Chapter 9-Regulatory Requirements and Applications of Physiologically Based Pharmacokinetic Models.- Chapter 10-Drug Drug and Food Drug Interactions of Pharmacokinetic Nature.- Part 2: Specialized topics.- Chapter 11-Nanocarriers: Delivery Routes.- Chapter 12-Advanced Techniques for Quality Assessment of Nanocarriers.- Chapter 13-Nanomedicines Obtained by Nanoprinting.- Chapter 14-Absorption, Distribution, Metabolism and Excretion of Biopharmaceutical Drug Products.- Chapter 15-In silico and in vitro ADME predictions.- Chapter 16-Relationship Between Pharmacokinetics and Pharmacogenomics and Its Impact on Drug Choice and Dose Regimens.- Chapter 17-The Relationship Between Pharmacogenomics and Pharmacokinetics and Its Impact on Drug Choice and Dosing Regimens in Pediatrics.- Chapter 18-Bioavailability and Bioequivalence studies.- Chapter 19-Drug transporters - Physiological role and Their Impact on Pharmacotherapy.- Chapter 20-Blood Flow Distribution and Membrane Transporters As Determinant Factors Of Tissue Drug Concentration.
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