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This book addresses chemical and biological aspects related to sesquiterpene lactones (STLs). Experts in different fields have been invited to contribute on this class of compound's chemistry, isolation and identification, biological activities (antibacterial, antifungal, antiviral, antitrypanosomal, antileishmanial,antiplasmodial, antiproliferative and antiinflammatory), synthesis, biosynthesis, derivatization and QSAR analysis. Taxonomic and chemotaxonomic aspects related to the Asteraceae family are also contributed.
Furthermore, experts in the field provide an in-depth discussion of the most commonly employed in vitro and in vivo antiprotozoal assays against the different stages of parasites, as well as STLs' properties as anticancer agents in numerous cancer cell lines and animal models. Lastly, the book presents examples of the in vitro and in vivo activity of STLs and their mechanism of antiprotozoal action, together with an analysis of ultrastructural alterations, observed using TEM techniques.
Prof. Dr. Valeria P. Sülsen: Valeria P. Sülsen has a Pharmacy B.Sc. (1998) and Ph.D. (2009) from University of Buenos Aires, Argentina. She got a Posdoctoral Research Fellowship at the Institute of Chemistry and Metabolism of Drugs (IQUIMEFA), University of Buenos Aires - National Scientific and Technical Research Council (CONICET) from 2009 to 2011. In 2011, she received the "Felix de Azara" Award for the best work on flora and fauna of Argentina (Faculty of Pharmacy and Biochemistry, University of Buenos Aires, Argentina) and the Award for the Best Thesis (Faculty of Pharmacy and Biochemistry, University of Buenos Aires, Argentina), in 2009. Nowadays she is a Researcher of The National Scientific and Technical Research Council working at Institute of Chemistry and Metabolism of Drugs (IQUIMEFA) - University of Buenos Aires and member of the research network Natural Products against Neglected Diseases (NPND). She is Assistant Professor of Pharmacognosy, Faculty of Pharmacy and Biochemistry, University of Buenos Aires, Argentina. Her main expertise areas are pharmacognosy and antiprotozoal natural products.
Prof. Dr. Virginia S. Martino: She has a Pharmacy B.Sc. (1970) and Ph.D. (1983) from University of Buenos Aires, Argentina. Specialist in Policy and Management of Science and Technology (2011). She joined the National Scientific and Technical Research Council in 1982 working at the Institute of Chemistry and Metabolism of Drugs (IQUIMEFA) - Faculty of Pharmacy and Biochemistry-University of Buenos Aires. She is member of the National Academy of Pharmacy and Biochemistry (Argentina). Awards received: "Felix de Azara" (Faculty of Pharmacy and Biochemistry, University of Buenos Aires, Argentina) (1984, 1989, 2011); Dr. Bernardo Houssay (2003)(CEDIQUIFA); Dr. Alfredo Bandoni (1993) (National Academy of Pharmacy and Biochemistry). She was Head Professor of Pharmacognosy at the Faculty of Pharmacy and Biochemistry, University of Buenos Aires between 2005 and 2014.
Part1. Chemical and biochemical aspects of sesquiterpene lactones.- Chapter1. Overview.- Chapter2. Ancient and modern concepts about the asteraceae taxonomy.- Chapter3. Chemotaxonomic study of sesquiterpene lactones of asteraceae: classical and modern methods.- Chapter4. Biosynthesis of sesquiterpene lactones in plants and metabolic engineering for their biotechnological production.- Chapter5. Chemistry of sesquiterpene lactones.- Chapter6. Analytical procedures.- Chapter7. Spectroscopic methods for the identification of sesquiterpene lactones.- Part2. Biological activities of sesquiterpene lactones.- Chapter8. Antitrypanosomal and antileishmanial activities.- Chapter9. Antiplasmodial activity.- Chapter10. Mode of action on trypanosoma and leishmania spp.- Chapter11. Contribution of microscopy for understanding the mechanism of action against trypanosomatids.- Chapter12. Effects on other microorganisms.- Chapter13. Antiproliferative and cytotoxic activities.- Chapter14. Anti-inflammatory activity.- Part3. Sesquiterpene lactones: medicinal chemistry approach.- Chapter15. Structure-activity and activity-activity relationships of sesquiterpene lactones.
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