Gigantism and Acromegaly brings together pituitary experts, taking readers from bench research, to genetic analysis, clinical analysis, and new therapeutic approaches. This book serves as a reference for growth hormone over-secretion and its diagnosis and treatment for endocrinologists, pediatricians, internists, and neurosurgeons, and for geneticists. Pharmaceutical companies may use it as a reference for drug development and research. Students, residents and fellows in medicine and endocrinology and genetics will also find it valuable as it provides a single up-to-date review of the molecular biology of gigantism and acromegaly as well as recommended approaches to evaluation and management.
Acromegaly is a rare pituitary disorder that slowly changes its adult victim's appearance over time: larger hands and feet, bigger jaw, forehead, nose, and lips. Generally, a benign pituitary tumor is the cause and symptoms of acromegaly can vary from patient to patient, making a diagnosis difficult and prolonging suffering for years. Early detection is key in the management of acromegaly as the pathologic effects of increased growth hormone (GH) production are progressive and can be life-threatening as the result of associated cardiovascular, cerebrovascular, and respiratory disorders and malignancies.
- Accessible, up-to-date overview of the characteristics, state-of-the-art diagnostic procedures, and management of acromegaly and gigantism
- Provides a unique compendium of endocrinology, genetics, clinical diagnosis and therapeutics
- Contains contributions from internationally known experts who have treated patients with acromegaly and gigantism
Sprache
Verlagsort
Verlagsgruppe
Elsevier Science & Techn.
Dateigröße
ISBN-13
978-0-12-814538-8 (9780128145388)
Schweitzer Klassifikation
1. History of the identification of gigantism and acromegalyLiliya Rostomyan, Albert Beckers and Patrick Petrossians2. Pathology of pituitary growth hormone excessSylvia L. Asa and Shereen Ezzat3. Gigantism: clinical diagnosis and description, Iulia PotoracLiliya Rostomyan, Adrian F. Daly, Patrick Petrossians and Albert Beckers4. Acromegaly: clinical description and diagnosisKevin C.J. Yuen and Albert Becker5. GPR101, an orphan G-protein coupled receptor, with roles in growth, puberty, and possibly appetite regulationFady Hannah-Shmouni and Constantine A. Stratakis6. The role of the aryl hydrocarbon receptor interacting protein in pituitary tumorigenesisLaura C. Hernändez-Rami¿rez7. The 3PAs syndrome and succinate dehydrogenase deficiency in pituitary tumorsParaskevi Xekouki, Vasiliki Daraki, Grigoria Betsi, Maria Chrysoulaki, Maria Sfakiotaki, Maria Mytilinaiou and Constantine A. Stratakis8. CDKN1B (p27) defects leading to pituitary tumorsSebastian Gulde and Natalia S. Pellegata9. Multiple endocrine neoplasia syndromes and somatotroph adenomasCarolina R.C. Pieterman and Steven G. Waguespack10. GNAS, McCuneErika Peverelli, Donatella Treppiedi, Federica MangiliRosa Catalano and Giovanna Mantovani11. Surgical management of growth hormone-secreting adenomasElizabeth Hogan and Prashant Chittiboina12. Medical management of pituitary gigantism and acromegalyAdrian F. Daly and Albert Beckers 13. GHRH-producing tumors and other neuroendocrine neoplasms associated with acromegaly and/or gigantismSara Pakbaz, Anjelica Hodgson and Ozgur Mete 14. Increased growth hormone secretion from lesions outside the anterior pituitaryChristina Tatsi and Constantine A. Stratakis
