Ion Channels as Targets in Drug Discovery

Ion Channels as Targets in Drug Discovery: outlook and perspectives.- Conservation of ligand binding between voltage-gated sodium and T-type calcium channels.- The presynaptic a2d protein family and their therapeutic potential.- Sodium channel in central hyperexcitability disease.- Therapeutic targeting of voltage-gated potassium channels.- The contribution of genetic sequencing information to the identification and functional characterisation of two pore domain (K2P) channels as viable therapeutic targets.- The voltage-gated potassium channel KV2.1 as a multicellular drug target.- Cystic fibrosis transmembrane conductance regulator (CFTR)-targeted therapeutics for cystic fibrosis.- Validation of TMEM16A modulation as a therapeutic approach for the treatment of cystic fibrosis - the discovery of novel TMEM16A potentiators.- Targeting acid-sensing ion channels in disease.- Transient Receptor Potential Canonical (TRPC) as a Therapeutic Drug Target.- Nicotinic receptors of the neuronal and non-neuronal cholinergic systems as therapeutic targets: Opportunities and limitations.- Purinergic P2X receptors as therapeutic targets.- Immune Cell Ion Channels as Therapeutic Targets.- Ion channel tools and therapeutics from venoms and toxins.