Handbook of Basal Ganglia Structure and Function, Second Edition, offers an integrated overview of the structural and functional aspects of the basal ganglia, highlighting clinical relevance. The basal ganglia, a group of forebrain nuclei interconnected with the cerebral cortex, thalamus, and brainstem, are involved in numerous brain functions, such as motor control and learning, sensorimotor integration, reward, and cognition.
These nuclei are essential for normal brain function and behavior, and their importance is further emphasized by the numerous and diverse disorders associated with basal ganglia dysfunction, including Parkinson's disease, Tourette's syndrome, Huntington's disease, obsessive-compulsive disorder, dystonia, and psychostimulant addiction.
This updated edition has been thoroughly revised to provide the most up-to-date account of this critical brain structure. Edited and authored by internationally acclaimed basal ganglia researchers, the new edition contains ten entirely new chapters that offer expanded coverage of anatomy and physiology, detailed accounts of recent advances in cellular/molecular mechanisms and cellular/physiological mechanisms, and critical, deeper insights into the behavioral and clinical aspects of basal ganglia function and dysfunction.
- Synthesizes widely dispersed information on the behavioral neurobiology of the basal ganglia, including advances in the understanding of anatomy, cellular/molecular and cellular/physiological mechanisms, and behavioral and clinical aspects of function and dysfunction
- Written by international authors who are preeminent researchers in the field
- Explores, in full, the clinically relevant impact of the basal ganglia on various psychiatric and neurological diseases
Auflage
Sprache
Verlagsort
Verlagsgruppe
Elsevier Science & Techn.
ISBN-13
978-0-12-802526-0 (9780128025260)
Schweitzer Klassifikation
Part A: The Basal Ganglia System and its Evolution1. History of the Basal Ganglia2. Anatomical Organization of the Basal Ganglia 3. Evolution of the Vertebrate Basal Ganglia 4. Cell Types in the Basal Ganglia
Part B: Anatomy and Physiology of the Striatum5. Striatal Medium Spiny Projection Neurons and their Connections6. Cholinergic Interneurons of the Striatum7. GABAergic Interneurons of the Striatum 8. Dopamine Signaling in Striatal Medium Spiny Neurons9. Endocannabinoid Signaling in the Striatum 10. Nitric Oxide Signaling in the Striatum 11. Adenosine Signaling in the Basal Ganglia
Part C: Anatomy and Physiology of Globus Pallidus, Subthalamic Nucleus and Substantia Nigra12. The Globus Pallidus 13. The Subthalamic Nucleus14. The Substantia Nigra Pars Reticulata15. Subtypes of Midbrain Dopamine Neurons16. Neurophysiology of Substantia Nigra Dopamine Neurons17. Plasticity in Dopamine Neurons18. Regulation of Extracellular Dopamine: Release and Reuptake
Part D: Network Integration19. Organization of Corticostriatal Projection Neuron Types 20. Organization of Prefrontal-Striatal Connections 21. Gating of Cortical Input to the Striatum 22. Corticostriatal Synaptic Plasticity in Physiological and Pathological Conditions 23. Organization of the Thalamostriatal Systems 24. The Rostromedial Tegmental Nucleus: Connections to the Basal Ganglia25. The Rostromedial Tegmental Nucleus: A Modulator of Dopamine Systems26. Integrative Networks Across Basal Ganglia Circuits
Part E: Molecular Signaling in the Basal Ganglia27. Second-Messenger Cascades 28. DARPP32/Phosphatase Signaling29. Transsynaptic Regulation of Basal Ganglia Gene Expression30. Psychostimulant-Induced Gene Regulation in Corticostriatal Circuits 31. Epigenetics in Neuropathologies of the Basal Ganglia
Part F: Basal Ganglia Function and Dysfunction32. Investigating Basal Ganglia Function with Cell-Type-Specific Manipulations33. Basal Ganglia Re-Entrant Loops: Roles in Action Selection and Reinforcement34. Memory Systems in the Basal Ganglia35. Basal Ganglia Dynamics During Action Sequence (Motor) Learning36. Abnormal Activities in Cortico-Basal Ganglia Circuits in Movement Disorders37. Morphological Plasticity in the Striatum Associated with Dopamine Dysfunction38. Neuroinflammation in Movement Disorders39. Basal Ganglia Disorders Related to Striosome/Matrix Compartments40. Drug Addiction: the Neural and Psychological Basis of a Compulsive Incentive Habit41. Parkinson's Disease: Cross-Talk Between Environmental Factors and Gene Defects 42. Parkinson's Disease: Molecular Determinants of Vulnerability in Dopamine Neurons43. Parkinson's Disease: Genetics 44. Molecular Mechanisms of L-DOPA-Induced Dyskinesia 45. Cell Therapy in Parkinson's Disease: An Update46. Huntington's Disease: Molecular Basis 47. Huntington's Disease: Insights from Animal Models48. Dystonia49. Tourette Syndrome50. Deep-Brain Stimulation for Neurologic and Psychiatric Disorders
