High-Throughput Screening Methods in Toxicity Testing

Explores the benefits and limitations of the latesthigh-throughput screening methods
With its expert coverage of high-throughput in vitroscreening methods for toxicity testing, this book makes it possiblefor researchers to accelerate and streamline the evaluation andrisk assessment of chemicals and drugs for toxicity. Moreover, itenables them to comply with the latest standards set forth by theU.S. National Research Council's "Toxicity Testing in the 21stCentury: A Vision and Strategy" and the E.U.'s REACH legislation.Readers will discover a variety of state-of-the-science,high-throughput screening methods presented by a group of leadingauthorities in toxicology and toxicity testing.
High-Throughput Screening Methods in Toxicity Testing isdivided into five parts:
* General aspects, including predicting the toxicity potential ofchemicals and drugs via high-throughput bioactivity profiling
* Assessing different cytotoxicity endpoints
* Assessing DNA damage and carcinogenesis
* Assessing reproductive toxicity, cardiotoxicity, andhaematotoxicity
* Assessing drug metabolism and receptor-related toxicity
Each chapter describes method principles and includes detailedinformation about data generation, data analysis, and applicationsin risk assessment. The authors not only enumerate the advantagesof each high-throughput method over comparable conventionalmethods, but also point out the high-throughput method'slimitations and potential pitfalls. In addition, the authorsdescribe current research efforts to make high-throughput toxicityscreening even more cost effective and streamlined.
Throughout the book, readers will find plenty of figures andillustrations to help them understand and perform the latesthigh-throughput toxicity screening methods.
This book is ideal for toxicologists and other researchers whoneed to implement high-throughput screening methods for toxicitytesting in their laboratories as well as for researchers who needto evaluate the data generated by these methods.