Aflatoxins: Biochemistry, Toxicology, Public Health, Policies and Modern Methods of Analysis

Name: Aflatoxins: Biochemistry, Toxicology, Public Health, Policies and Modern Methods of Analysis
Brand: Nova Science Publishers Inc
Price: 284.99 EUR
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Kintzios Spyridon(Herausgeber*in)

Nova Science Publishers Inc

Erschienen am 20. Dezember 2019

346 Seiten

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978-1-5361-6786-3 (ISBN)

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Inhalt

Intro
Contents
Preface
List of Acronyms
Part I: Biological Effects of Aflatoxins
Chapter 1
Combined Toxicity of Aflatoxins and Ochratoxin A
Abstract
1. Introduction
2. Methods
2.1. Searching Strategy
2.2. Study Selection
2.3. Data Extraction
3. In Vitro Studies
4. In Vivo Studies
5. Reviews
Funding
References
Chapter 2
Aflatoxins, Oxidative Stress and Regulation of Glutathione Redox System
Abstract
1. Introduction
2. Oxidative Stress and Antioxidant Defense Mechanisms
2.1. Oxidative Stress
2.2. Antioxidant Defence System
2.2.1. First Line of Antioxidant Defense
2.2.2. Second Line of the Antioxidant Defense
2.2.3. Third Line of the Antioxidant Defense
3. Glutathione Redox System and Its Regulation
3.1. Regulation of Glutathione Redox System
3.2. Effect of Reactive Oxygen Species on Aflatoxin Biosynthesis
4. Aflatoxin-Induced Oxidative Stress in Animals and Humans
4.1. Aflatoxicosis and the Oxidative Stress
4.2. Aflatoxin-Induced Oxidative Stress in Animals
4.3. Aflatoxin-Induced Oxidative Stress in Humans
5. Antioxidant Response to Aflatoxin-Induced Oxidative Stress and Its Regulation
References
Biographical Sketch
Chapter 3
Analytical Methods for Aflatoxin Human Biomonitoring
Abstract
1. Introduction
2. Methods
3. Results and Discussion
3.1. Sample Preparation
3.2. Detection and Quantification
3.2.1. Human Urine
3.2.2. Human Plasma/Serum/Blood
3.2.3. Human Breast Milk
Conclusion
Acknowledgments
References
Part II: Methodological Approaches for Aflatoxin Determination
Chapter 4
Commercial Immunoassays for Detecting Aflatoxins
Abstract
1. Introduction
2. Structural Diversity Amongst the Aflatoxins
3. Extraction of Aflatoxins
4. Sensitivity and Regulatory Levels
5. Screening Technologies
6. Commercial Aflatoxin Screening Assays
7. Validation of Commercial Test Kits
8. Additional Resources
Conclusion
Disclaimer
References
Chapter 5
Metabolomics in Aspergillus Research: Potential and Applications in Biotechnology, Industry, Medicine, and Crop Protection
Abstract
1. The Genus Aspergillus
1.1. Species
1.2. Aflatoxins (AF)
2. Metabolomics in Aspergillus Reseach
2.1. Natural Product Discovery
2.2. Discovery of Aflatoxin (AF) Biosynthesis Inhibitors
2.3. Mining the Resistance of Aspergillus Sp. to Bioactive Compounds
2.4. Chemotaxonomy of Aspergilli
2.5. Effect of PPPs and Fungal Resistance to PPPs on the Aflatoxin (AF) -Biosynthetic Capacity of Aspergilli
2.6. Bioinformatics and Online Resources in Aspergillus Research
References
Chapter 6
Predictive Modelling of Aspergillus Flavus Growth and Aflatoxins Production
Abstract
1. Introduction
2. Predictive Models Applied to A. Flavus Germination, Growth and Inactivation
2.1. Germination Models
2.2. Growth Models
2.3. Inactivation Models
3. Aflatoxins Modelling
References
Chapter 7
Review of the Analytical Methodologies and Occurrence Data of Aflatoxins in Cereals and Cereal-Based Foods in Spain
Abstract
1. Introduction
2. Methods
3. Results and Discussion
3.1. Aflatoxin Extraction
3.2. Aflatoxin Analysis
3.3. Aflatoxin Occurrence
Conclusion
Acknowledgments
References
Part III: Strategies for Aflatoxin-Associated Risk Mitigation and Legislation Strategies
Chapter 8
Pre-Harvest Management Strategies to Control Aflatoxin Contamination in Crops
Abstract
Introduction
1. Biological Control of Aflatoxins
1.1. Biological Control of Aflatoxins Using Atoxigenic Strains of A. Flavus
1.2. Biological Control of Aflatoxins Using Yeasts
1.3. Biological Control of Aflatoxins Using Bacteria
2. Chemical Control of Aflatoxigenic Fungi and Aflatoxins
3. Predictive Models
4. Good Agricultural Practices (GAPs)
5. Novel Detection and Monitoring Techniques
5.1. Novel Detection Techniques
5.2. Novel Monitoring Techniques
Conclusion
Acknowledgments
References
Chapter 9
Aflatoxins in Food and Feed: Occurrence, Legislation and Mitigation Strategies
Abstract
1. Introduction
2. Occurrence and Legislation of Aflatoxins
3. Mitigation Strategies
4. Pre-Harvesting: Prevention of Aflatoxin Contamination
4.1. Biological Methods
5. Post-Harvesting: Decontamination and Prevention of Aflatoxins
5.1. Biological Control
5.2. Physical Methods
5.2.1. Sorting
5.2.2. Electromagnetic Radiation
5.2.2.1. Microwave Radiation
5.2.2.2. Infra-Red, Visible and Ultraviolet Radiation
5.2.2.3. Gamma- and Electron Beam Radiation
5.2.3. Packaging Material
5.3. Chemical Methods
5.3.1. Ozone Fumigation
5.3.2. Electrolyzed Water
5.3.3. Food Additives
Conclusion
References
About the Editors
Index
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