Trials for Cerebellar Ataxias

Part I: Basic Science of Cerebellum and Ataxias .- Functional anatomy of the cerebellum.- Cerebellar physiology.- Cerebellar biochemistry/pharmacology.- Genetics of dominant ataxias.- Autosomal and X-linked degenerative ataxias: from genetics to promising therapeutics.- Seeking therapies for Spinocerebellar Ataxia: from gene silencing to systems-based approaches.- Ion Channel Genes and Ataxia.- Part II: Biomarkers and tools of trials .- How to Design a Therapeutic Trial in SCAs.- Therapy development for spinocerebellar ataxia: Rating Scales and Biomarkers.- Clinical rating scales for ataxia.- Scale for Ocular motor Disorders in Ataxia (SODA): Procedures and Basic Understanding.- Cerebellar learning in the prism adaptation task.- Blood and CSF biomarkers in autosomal dominant cerebellar ataxias.- Part III: Autosomal Dominant Cerebellar Ataxias .- Riluzole in progressive cerebellar ataxias.- ASOs against ATXN2 in preclinical and phase 1 trials.- Antisense oligonucleotide therapy against SCA3.- Spinocerebellar ataxia type 7: From mechanistic pathways to therapeutic opportunities.- Experimental neurotransplantation for cerebellar ataxias.- Development of mesenchymal stem cells therapy for the treatment of polyglutamine SCA: from bench to bedside.- Cerebello-Spinal tDCS as Rehabilitative Intervention in Neurodegenerative Ataxia.- Cerebellar Transcranial Magnetic Stimulation in Cerebellar Ataxias.- Physical therapy in Cerebellar Ataxia.- Part IV: Autosomal Recessive Cerebellar Ataxias .- Recent advances on therapeutic approaches for Friedreich's Ataxia.- Therapeutic use of interferon gamma in Friedreich ataxia.- Metabolic treatments of cerebellar ataxia.- Clinical Trials in Fragile X-Associated Tremor/Ataxia Syndrome.- Part V: Sporadic Ataxias .- Therapeutic strategies inimmune-mediated cerebellar ataxias.- Coenzyme Q10 in MSA.- State of the Art and History of Therapeutics in Ataxias.