Computational Neuroscience in Epilepsy

ContributorsForewordRise of the Machines - On the Threshold of a New Era in Epilepsy ResearchIntroduction: Applications and Emerging Concepts of ComputationalNeuroscience in Epilepsy ResearchPart I Computational Modeling Techniques and Databases in Epilepsy Research 1 Simulation of Large Networks: Technique and Progress 2 The Neuron Simulation Environment in Epilepsy Research 3 The CoCoDat Database: Systematically Organizing and Selecting Quantitative Data on Single Neurons and Microcircuitry 4 Validating Models of Epilepsy 5 Using NeuroConstruct to Develop and Modify Biologically Detailed 3D Neuronal Network Models in Health and Disease 6 Computational Neuroanatomy of the Rat Hippocampus: Implications and Applications to EpilepsyPart II Epilepsy and Altered Network Topology 7 Modeling Circuit Alterations in Epilepsy: A Focus on Mossy Cell Loss and Mossy Fiber Sprouting in the Dentate Gyrus 8 Functional Consequences of Transformed Network Topology in Hippocampal Sclerosis 9 Multiple-Scale Hierarchical Connectivity of Cortical Networks Limits the Spread of ActivityPart III Destabilization of Neuronal Networks 10 Computer Simulations of Sodium Channel Mutations that Cause Generalized Epilepsy with Febrile Seizures Plus 11 Gain Modulation and Stability in Neural Networks 12 Neocortical Epileptiform Activity in Neuronal Models with Biophysically Realistic Ion Channels 13 Corticothalamic Feedback: A Key to Explain Absence Seizures 14 Mechanisms of Graded Persistent Activity: Implications for Epilepsy 15 Small Networks, Large Networks, Experiment and Theory - Can We Bring Them Together with Oscillations, Heterogeneity and Inhibition?Part IV Homeostasis and Epilepsy 16 Stability and Plasticity in Neuronal and Network Dynamics 17 Homeostatic Plasticity and Post-Traumatic EpileptogenesisPart V Mechanisms of Synchronization 18 Synchronization in Hybrid Neuronal Networks 19 Complex Synaptic Dynamics of GABAergic Networks of the Hippocampus 20 Experimental and Theoretical Analyses of Synchrony in Feedforward Networks 21 Modulation of Synchrony by Interneurons: Insights from Attentional Modulation of Responses in the Visual CortexPart VI Interictal to Ictal Transitions 22 Cellular and Network Mechanisms of Oscillations Preceding and Perhaps Initiating Epileptic Discharges 23 Transition to Ictal Activity in Temporal Lobe Epilepsy: Insights from Macroscopic Models 24 Unified Modeling and Analysis of Primary Generalized Seizures 25 A Neuronal Network Model of Corticothalamic Oscillations: The Emergence of Epileptiform Absence Seizures 26 Extracellular Potassium Dynamics and Epileptogenesis 27 Slow Waves Associated with Seizure ActivityPart VII Seizure Dynamics 28 Dynamics of Epileptic Seizures during Evolution and Propagation 29 Are Correlation Dimension and Lyapunov Exponents Useful Tools for Prediction of Epileptic Seizures? 30 Towards a Dynamics of Seizure MechanicsPart VIII Towards Computer-Aided Therapy 31 Principles and Practice of Computer-Aided Drug Design as Applied to the Discovery of Antiepileptic Agents 32 Computation Applied to Clinical Epilepsy and Antiepileptic Devices 33 Microelectrode-based Epilepsy Therapy: A Hybrid Neural Prosthesis Incorporating Seizure Prediction and Intervention with Biomimetic Maintenance of Normal Hippocampal FunctionIndex