Presenting a complete overview of the effects of steroid hormones in the brain and describing new methods for investigating these effects, this book discusses theories on steroid action in the central nervous system and the techniques for receptor localization and quantification and enzyme regulation. The author explores the use of transgenic/antisense strategies to determine sites and the cellular effects of steroid action in the brain. He covers steroid action on mood, cognition, sensorimotor action, neuroprotection, and plasticity, and describes methods using molecular, electrophysical, and behavioral techniques to link cellular mechanisms of steroid action with behavioral effects.
Rezensionen / Stimmen
"The overwhelming amount of information in the field is well presented in the superbly written book, the magnificent pictures, and the up-to-date references. This is a good purchase for general neurological and neuroscience libraries."
- Doody's
Promo Copy
Reihe
Auflage
Sprache
Verlagsort
Verlagsgruppe
Zielgruppe
Für Beruf und Forschung
Research scientists; clinicians; and graduate students interested in gaining further insight into novel aspects of steroid hormone actions in the central nervous system
Produkt-Hinweis
Illustrationen
66 s/w Abbildungen, 10 farbige Abbildungen, 12 s/w Tabellen
66 b/w images, 10 color images and 12 tables
ISBN-13
978-1-135-48672-3 (9781135486723)
Copyright in bibliographic data and cover images is held by Nielsen Book Services Limited or by the publishers or by their respective licensors: all rights reserved.
Schweitzer Klassifikation
Introduction. Synthesis, enzyme localization, and regulation of neurosteroids. Subunit specificity of steroid modulation of GABAA receptors. THDOC and the GABAA receptor. Neurosteoid modulation of delta subunit-containing GABA-A receptor channels. Potentiation and inhibition of GABAA receptor function by neuroactive steroids. Anabolic androgenic steroids and the brain: Novel actions at the GABAA receptor and on GABA-A receptor mediated behaviors. Withdrawal effects of a neuroactive steroid as a model of PMS: Synaptic physiology to behavior. GABA, estrogen, and sex differences in the brain. FGIN-1-X--A series of novel specific and efficacious ligands for the peripheral benzodiazepine receptor. GABAergic neuroactive steroids modulate selective ethanol actions: Mechanisms and significance. Allopregnanolone modulates the action of ethanol and stress on the activity of mesocortical dopaminergic neurons and HPA axis. 3a, 5a-THP's actions in the ventral tegmental area for lordosis: A model system for defining mechanisms and function of progestins. Premenstrual dysphoric disorder. Role of neurosteroids in epilepsy. Animal models of anxiety and stress-induced behavior: Effects of neuroactive steroids. Direct modulation of amino acid receptors by neuroactive steroids: Physiological and pharmacological Implications. On the neurosteroid mechanisms of action and their clinical potentials.
