Fluorine Chemistry V3

PrefaceAcknowledgmentsFluoroacetate Acute Human Poisoning Species Variations Occurrence in Nature Chemical Factors Cause of Death Pharmacological Properties Essential Biochemical Lesions Citrate Concentration Increase Nature of the Inhibitor Evidence for Fluorocitrate The Sites of Inhibition Aconitase Condensing Enzyme Acetoacetate Formation Amine Acetylation Thiol Esters Transacetylases Phosphotransacetylase F-Sensitive System Pigeon Liver Preparation Other Sources Metabolic Mechanisms: Summary Structure-Toxicity RelationsPhosphofluoridates Toxicity of DFP and Derivatives DFP Metabolism Studies of DFP32 Metabolism Enzymes Hydrolyzing DFP (DFPases)Acute Effects of Organofluorine Compounds in Experimental Animals Plan of Review Inhalation ToxicityEffects of Acute Doses of Fluorine-Containing Organic Compounds Anesthetic Effects Local Anesthetics Mephenesin Analogs Sympathomimetic Amines Metabolic Effects of Tyrosine Analogs 9a-Fluorocorticosteroids Effects of Organic Fluorine Compounds on Enzyme Systems Anti-Tumor Action Effects of Organofluorine Compounds on Microorganisms Antimalarials Fungistats Viruses Miscellaneous Pharmacological Effects of Organic Fluorides Rodent Repellency Organic Fluorine Compounds Useful as InsecticidesChronic Experimental IntoxicationMiscellaneousTables Table I. Acute Fatal Intoxication Caused by Sodium Fluoroacetate Table II. Acute, Nonfatal Intoxications Caused by Sodium Fluoroacetate Table III. Lethal Doses of Sodium Fluoroacetate in Various Species Table IV. Mean Lethal Dose (LD50) of Sodium Fluoroacetate in Various Species Table V. Mean Lethal Dose (LD50) of Methyl Fluoroacetate in Various Species Table VI. Mean Lethal Dose (LD50) of Organic Compounds Containing the C-F Link Table VII. Metabolic Interference in Systems Utilizing Pyruvate and Acetate Table VIII. Increase in Citrate Concentration Due to FAc Table IX. Inhibition of Citrate Oxidation Table X. Citric Acid Content of Rat Tissues in Vivo following Injection of Fluoroacetate Table XI. The Toxicity of and Citrate Accumulation Caused by Representative Even and Odd ¿-Fluoro Compounds Administered to Mice Table XII. Comparative Toxicities of DFP, Sarin, and Tabun in the Mouse Table XIII. Mean Lethal Dose (LD50) of Diisopropyl Phosphofluoridate in Various Species Table XIV. Mean Lethal Dose (LD50) of Organic Fluorophosphate Compounds Table XV. Hydrolysis of Diisopropyl Phosphofluoridate by Tissue Extracts Table XVI. Acute Doses of Fluorine-Containing Organic Compounds in Various Species Table XVII. Approximate Lethal Concentration of Fire Extinguisher Compounds in Order of Increasing Toxicity Table XVIII. Toxic Effects of Fluorocarbons by Inhalation Table XIX. Miscellaneous Effects of Fluorine-Containing Organic Compounds Table XX. Fluorine-Containing Organic Compounds Tested for Anesthetic Properties Table XXI. Glucocorticoid and Mineralocorticoid Activities of Fluorocorticosteroids Table XXII. Effects of Fluorine-Containing Compounds on Enzyme Systems Table XXIII. Fluorine-Containing Organic Compounds Tested as Tumor Inhibitors in the Mouse Table XXIV. Effects of Fluorine-Containing Organic Compounds upon Microorganisms Table XXV. Fluorine-Containing Compounds Tested as Antimalarial Agents Table XXVI. Additional Fluorine-Containing Compounds Tested as Antimalarials Table XXVII. Effects of Fluorine-Containing Organic Compounds upon Fungi Table XXVIII. Breaking Strength of Cotton Thread Treated with Fungicides and Exposed 14 Days to Mycothecium verrucario Table XXIX. Repellency Index for Rats of Fluorine-Containing Organic Compounds Table XXX. Activity of Difluorodiphenyltrichloroethane (DFDT) against Pests Table XXXI.