Migraine Management: Current Pharmacological and Non-pharmacological Options is a comprehensive guide to established, recent, and ongoing pharmaceuticals and device development projects. The book provides detailed information on the historical developments of migraine pain management, druggable targets, drugs action mechanisms, drugs for acute treatment and preventive care of patients, administration routes, and alternative treatments. This is the ideal reference for academic researchers interested in anti-migraine pharmacology. It will also be a perfect reference for physicians and care professionals involved in the well-being of migraine patients.
- Offers a comprehensive overview of pharmacological and alternative migraine pain treatment options
- Covers the historical developments and current targets for drug development and delivery routes
- Provides insights into comorbidities and their impact in patient compliance to treatment
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ISBN-13
978-0-443-24704-0 (9780443247040)
Schweitzer Klassifikation
Part I: Foundations and historical development of migraine pain management1. Introduction2. Neuroanatomy and Neurophysiology3. Historical overview of migraine product development4. Comorbidities and their impact on therapies5. Not all Migraine attacks are the same6. Challenges and Controversies; Pharmacokinetics, Linguistics, Semantics and StatisticsPart II: Druggable targets7. CGRP8. PACAP9. Src family kinases (SFK) in Migraine10. Delta opioid receptor system11. Piezo channels in peripheral trigeminal nociception12. TRP antagonistsPart III: Drugs - Acute Management13. Simple analgesics and combination oral products14. Cannabinoids & Phytochemicals15. Ergots16. Triptans17. Beta blocker (timolol) eye drops18. Lasmiditan (and the ditan class)19. GepantsPart IV: Drugs - Prevention20. TCAs (Tricyclic Antidepresants), SNRIs, Beta blockers, candesartan, flunarizine21. Antiseizure orals (gabapentin, topiramate)22. Onabotulinumtoxin23. Gepants (for prevention)24. (CGRP) Monocloncal antibodiesPart V: Administration routes25. Oral Drugs (including SMEDDS)26. Inhaled - oral & nasal27. Subcutaneous/IM/Transcutaneous ("Injectables")28. IV/InfusionPart VI: Alternative Management29. The role of digital platforms and smartphone apps30. Herbal Medicines31. Phototherapy32. Neuromodulation33. Acupuncture (for episodic and chronic migraine)34. Manual Therapies35. Nutraceuticals and Diets36. MindfulnessPart VII: Summary & conclusion [Shrewsbury]37. Final Perspectives: oral/non-oral pharmaceuticals; devices; Complimentary practices
