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List of Contributors
Preface to the Fourth Edition
Preface to the First Edition
Historical Introduction: The Drug Treatment of Epilepsy from 1857 to 2015 Simon Shorvon
Section I ? Introduction (Lead editor: Simon Shorvon)
1 Definition (Terminology) and Classification in Epilepsy: A Historical Survey and Current Formulation, with Special Reference to the ILAE 1Simon Shorvon
2 Differential Diagnosis of Epilepsy 24Mark Cook
3 Mechanisms of Epileptogenesis 38Giuliano Avanzini and Silvana Franceschetti
4 Antiepileptic Drug Discovery 52H. Steve White and Melissa Barker-Haliski
5 Antiepileptic Drug Development 61Dieter Schmidt
6 Mechanisms of Antiepileptic Drug Action 75Matthew C. Walker and Rainer Surges
7 Mechanisms of Drug Resistance and Tolerance 92Wolfgang Loscher and Dieter Schmidt
8 Epilepsy Biomarkers 103Jerome Engel, Jr. and Asla Pitkanen
Section II ? Principles of Medical Management (Lead editor: Simon Shorvon)
9 General Principles of Medical Management 110Emilio Perucca
10 Pharmacokinetic Optimization of Therapy 124Svein I. Johannessen, Cecilie Johannessen Landmark and Emilio Perucca
11 Management of Chronic Active Epilepsy in Adults 139Simon Shorvon
12 Management of Epilepsy in Remission 148Patrick Kwan, Howan Leung and Xiaoting Hao
13 Management of Epilepsy in Neonates and Infants 156Elissa G. Yozawitz and Solomon L. Moshe
14 Management of Childhood Epilepsy Syndromes 174Colin D. Ferrie
15 Management of Epilepsy in People with Intellectual Disabilities 193Eylert Brodtkorb
16 Management of Epilepsy in the Elderly 205Hiba Arif Haider and Lawrence J. Hirsch
17 Emergency Treatment of Seizures and Status Epilepticus 221Matthew C. Walker and Simon Shorvon
18 Management of Medical Comorbidity Associated with Epilepsy 245Gagandeep Singh
19 Psychiatric Features of Epilepsy and their Management 259Brent Elliott and Simon Shorvon
20 Prevention and Management of Side-effects of Antiepileptic Drugs 275Gaetano Zaccara and Piero Perucca
21 Ketogenic Diets 288Eric H. Kossoff and Courtney A. Haney
22 Complementary and Alternative Treatments for Epilepsy 298Sallie Baxendale
23 Reproductive Aspects of Epilepsy Treatment 311Torbjorn Tomson
24 Genetic Counselling in Epilepsy 323Federico Zara
25 Drug Interactions 344Edoardo Spina and Domenico Italiano
26 Medical Treatment of Epilepsy in Resource-Poor Countries 360Patrick Adjei
Section III ? Antiepileptic Drugs (Lead editor: Emilio Perucca)
27 Introduction to the Choice of Antiepileptic Drugs 365Emilio Perucca
28 Acetazolamide 376Miri Y. Neufeld
29 Adrenocorticotropic Hormone and Corticosteroids 388Federico Vigevano and Maria Roberta Cilio
30 Benzodiazepines Used in the Treatment of Epilepsy 398Eugen Trinka and Francesco Brigo
31 Brivaracetam 418Joseph D?Souza and Emilio Perucca
32 Carbamazepine 431Torbjorn Tomson and Svein I. Johannessen
33 Eslicarbazepine Acetate 447Meir Bialer and Christian Elger
34 Ethosuximide 460Tracy A. Glauser and Emilio Perucca
35 Felbamate 472Ilo E. Leppik and James R. White
36 Gabapentin 479Ernest R. Somerville, Andrew W. Michell and Arjune Sen
37 Lacosamide 489Rajesh Sachdeo and Roopal Karia
38 Lamotrigine 498Awais Riaz and Fumisuke Matsuo
39 Levetiracetam 516Derek J. Chong and Jacqueline A. French
40 Oxcarbazepine 533Edward Faught and Hyunmi Kim
41 Perampanel 546Martin Brodie
42 Phenobarbital, Primidone and Other Barbiturates 555Roberto Michelucci and Elena Pasini
43 Phenytoin 574Mervyn J. Eadie
44 Piracetam 589Simon D. Shorvon
45 Pregabalin 595Sylvain Rheims and Philippe Ryvlin
46 Retigabine 606Michel Baulac
47 Rufinamide 617Victor Biton
48 Stiripentol 628Tapani Keranen
49 Tiagabine 633Reetta Kalviainen
50 Topiramate 642J. Helen Cross and Catherine J. Riney
51 Valproate 652Anthony G. Marson and Graeme J. Sills
52 Vigabatrin 667Gunter Kramer and Gabriele Ch. Wohlrab
53 Zonisamide 680Michel Baulac
54 Other Less Commonly Used Antiepileptic Drugs 689Martin Holtkamp
55 Drugs in Clinical Development 701Norman Delanty and H. Steve White
Section IV ? Presurgical Assessment and Epilepsy Surgery (Lead editor: Jerome Engel, Jr.)
56 Overview of Surgical Treatment for Epilepsy 709Jerome Engel, Jr.
57 Scalp EEG in the Epilepsy Surgery Evaluation 723Christine B. Baca and John M. Stern
58 Invasive EEG in Presurgical Evaluation of Epilepsy 733Dennis Spencer, Dang K. Nguyen and Adithya Sivaraju
59 MEG in Epilepsy Surgery Evaluation 756Hermann Stefan and Paul Boon
60 MRI in Presurgical Evaluation 764Christian E. Elger and Bernd Weber
61 PET and SPECT in Presurgical Evaluation of Epilepsy 775Karolien Goffin and Wim Van Paesschen
62 Special Neurophysiological Techniques 787Francois Mauguiere and Julien Jung
63 Neuropsychological Testing in Presurgical Evaluation 804Marilyn Jones-Gotman and Gail L. Risse
64 Presurgical Psychiatric Evaluation 817Andres M. Kanner
65 Mesial Temporal Lobe Surgery and Other Lobar Resections 829James Leiphart and Itzhak Fried
66 Resective Surgery of Neoplasms 842Nicholas M. Wetjen and Gregory D. Cascino
67 Resective Surgery of Vascular and Infective Lesions for Epilepsy 858Christopher E. Uff and Neil D. Kitchen 68 Surgery of Developmental Anomalies Causing Epilepsy 878Ahyuda Oh, Joshua J. Chern and Youssef G. Comair
69 Hemispheric Operations for Epilepsy 887Georg Dorfmuller, Christine Bulteau and Olivier Delalande
70 Corpus Callosum Operations 895David W. Roberts
71 Hypothalamic Hamartoma 903John F. Kerrigan
72 Multiple Subpial Transection 916Adriana Bermeo-Ovalle and Michael C. Smith
73 Awake Surgery for Epilepsy 922Webster H. Pilcher
74 Epilepsy Surgery in Children 931Jason S. Hauptman and Gary W. Mathern
75 Complications of Epilepsy Surgery 941Charles E. Polkey
76 Anaesthesia for Epilepsy Surgery 952Barbara M. Van de Wiele
77 Vagus and Trigeminal Nerve Stimulation 959Steven C. Schachter
78 Brain Stimulation for Epilepsy 967Gregory K. Bergey and Robert S. Fisher
79 Non-Resective Approaches for Medically Intractable Epilepsy 980Thomas J. Gianaris, Andrea G. Scherer and Nicholas M. Barbaro
80 Future Focal Treatment Approaches to Epilepsy 987Laura Mantoan Ritter and Hannah Cock
81 Epilepsy Surgery in Countries with Limited Resources 999Andre Palmini and Kurupath Radhakrishnan
Index 1008
Patrick Adjei, MBCHB MWACP PhD Lecturer Neurology Unit Department of Medicine and Therapeutics School of Medicine and Dentistry University of Ghana Accra, Ghana
Giuliano Avanzini, MD Emeritus Professor of Neurology C. Besta Foundation Neurological Institute Milan, Italy
Christine B. Baca, MD MSHS Assistant Professor of Neurology Department of Neurology University of California and VA Greater Los Angeles Health Care System Los Angeles, USA
Nicholas M. Barbaro, MD Betsey Barton Professor and Chairman of Neurosurgery and Medical Director Department of Neurological Surgery and IU Health Neuroscience Center Indiana University School of Medicine Indianapolis, USA
Melissa Barker-Haliski, PhD Associate Director Anticonvulsant Drug Development Program University of Utah Salt Lake City, USA
Michel Baulac, MD Professor of Neurology and Neuroanatomy University Pierre and Marie Curie Hopital de la Pitie-Salpetriere, Paris, France
Sallie A. Baxendale, PhD Consultant Neuropsychologist UCL Institute of Neurology University College London London, UK
Gregory K. Bergey, MD Professor of Neurology and Director Johns Hopkins Epilepsy Center Johns Hopkins University School of Medicine Baltimore, USA
Adriana Bermeo-Ovalle, MD Assistant Professor Department of Neurological Sciences Rush University Medical Center Chicago, USA
Meir Bialer, PhD MBA David H. Eisenberg Professor of Pharmacology Institute for Drug Research School of Pharmacy Faculty of Medicine The Hebrew University of Jerusalem and David R. Bloom Center for Pharmacy Jerusalem, Israel
Victor Biton, MD Director of Arkansas Epilepsy Program and Clinical Trials, Inc. Little Rock Arkansas, USA
Paul Boon, MD PhD Professor and Chairman Department Neurology Ghent University Hospital Belgium and Director Research and Development Academic Center for Epileptology Kempenhaeghe-Maastricht The Netherlands
Francesco Brigo, MD Honorary Research Associate Department of Neurological and Movement Sciences University of Verona Verona, Italy
Martin J. Brodie, MB ChB MD FRCP Professor of Medicine and Clinical Pharmacology and Director, Epilepsy Unit Western Infirmary Glasgow, UK
Eylert Brodtkorb, MD, PhD Senior Consultant, Professor Department of Neurology and Clinical Neurology St. Olav's Hospital Trondheim University Hospital Trondheim, Norway
Christine Bulteau, MD Neurological Paediatrician Fondation Ophtalmologique Rothschild Paris, France Inserm U 1129 and Paris Descartes University Gif sur Yvette, France
Gregory D. Cascino, MD FAAN Whitney MacMillan, Jr. Professor of Neuroscience and Enterprise Director of Epilepsy Mayo Clinic and Mayo Clinic College of Medicine Rochester, USA
Joshua J. Chern, MD PhD Pediatric Neurosurgery Associate Neurosurgery Department Emory University Atlanta, USA
Derek J. Chong, MD MSc Assistant Professor of Neurology Director, Epilepsy and EEG Consult Services New York University Comprehensive Epilepsy Center New York, USA
Maria Roberta Cilio, MD PhD Professor, Neurology and Pediatrics Division of Epilepsy and Clinical Neurophysiology Benioff Children's Hospital University of California San Francisco, USA
Hannah R. Cock, BSc MD FRCP Reader in Clinical Neurology and Honorary Consultant Neurologist Atkinson Morley Regional Neuroscience Centre St Georges University Hospitals NHS Foundation Trust and St George's University of London London, UK
Youssef G. Comair, MD FRCSC Dean and Professor of Surgery Gilbert and Rose-Marie Chagoury School of Medicine Lebanese American University Beirut, Lebanon
Mark J. Cook, MB BS MD Sir John Eccles Chair of Medicine and Director of Clinical Neurosciences University of Melbourne and St Vincent's Hospital Melbourne, Australia
J. Helen Cross, MB PhD OBE Professor in Paediatric Neurology UCL Institute of Child Health University College London and Great Ormond Street Hospital for Children NHS Trust London, UK
Olivier Delalande, MD Neuorsurgeon Fondation Ophtalmologique Rothschild Paris, France
Norman Delanty, BSc FRCPI Consultant Neurologist and Director Epilepsy Programme Beaumont Hospital, RCSI Dublin, Ireland
Georg Dorfmüller, MD Director of Neurosurgery Fondation Ophtalmologique Rothschild Paris, France Inserm U 1129 and Paris Descartes University Gif sur Yvette, France
Joseph D'Souza, PhD Senior Director UCB Pharma Smyrna, USA
Mervyn J. Eadie, AO MD PhD FRCPEd FRACP Emeritus Professor of Clinical Neurology and Neuropharmacology and Honorary Consultant Neurologist University of Queensland and Royal Brisbane and Women's Hospital Brisbane, Australia
Christian E. Elger, MD FRCP Professor and Director Department of Epileptology University of Bonn Medical Center Bonn, Germany
Brent Elliott, MBBS MRCPsych Consultant Neuropsychiatrist Epilepsy Society Chalfont St Peter, UK
Jerome Engel, Jr., MD PhD Jonathan Sinay Distinguished Professor of Neurology Neurobiology, and Psychiatry and Biobehavioral Sciences Director UCLA Seizure Disorder Center David Geffen School of Medicine at University of California Los Angeles, USA
Edward Faught, MD Professor, Department of Neurology and Director, Emory Epilepsy Program Emory University School of Medicine Atlanta, USA
Colin D. Ferrie, MD FRCPCH Consultant Paediatric Neurologist Department of Paediatric Neurology Leeds General Infirmary Leeds, UK
Robert S. Fisher, MD PhD Maslah Saul MD Professor of Neurology Stanford University School of Medicine Palo Alto, USA
Silvana Franceschetti, MD PhD Head of Department of Neurophysiology C. Besta Foundation Neurological Institute Milan, Italy
Jacqueline A. French, MD Professor New York University Comprehensive Epilepsy Center New York, USA
Itzhak Fried, MD PhD Professor Department of Neurosurgery University of California Los Angeles, USA and Tel-Aviv Medical Center and Tel-Aviv University Tel-Aviv, Israel
Thomas J. Gianaris, MD Neurosurgeon Department of Neurological Surgery Indiana University School of Medicine Indianapolis, USA
Tracy A. Glauser, MD Professor Pediatrics and Neurology Children's Hospital Medical Center C-5 Cincinnati, USA
Karolien Goffin, MD PhD Assistant Professor Department of Nuclear Medicine University Hospital Leuven Department of Imaging & Pathology KU Leuven Leuven, Belgium
Hiba Arif Haider, MD Fellow in Clinical Neurophysiology/Epilepsy Emory University School of Medicine Atlanta, USA
Courtney A. Haney, RD Registered Dietitian Johns Hopkins University School of Medicine Baltimore, USA
Xiaoting Hao, MD Neurologist The West China School of Medicine and West China Hospital Chengdu, China
Jason S. Hauptman, MD PhD staff Pediatric Neurosurgeon Department of Neurosugery Kaiser Permanente Los Angeles Medical Center Los Angeles, USA
Lawrence J. Hirsch, MD Professor of Neurology Chief, Division of Epilepsy and EEG and Co-Director Comprehensive Epilepsy Center Yale University School of Medicine New Haven, USA
Martin Holtkamp, MD Friedrich v. Bodelschwingh-Professor for Clinical and Experimental Epileptology Epilepsy Center Berlin-Brandenburg Department of Neurology Charité - Universitätsmedizin Berlin Berlin, Germany
Domenico Italiano, MD PhD Research Fellow Department of Clinical and Experimental Medicine University of Messina Messina, Italy
Svein I. Johannessen, PhD Senior Researcher Department of Pharmacology The National Center for Epilepsy Oslo University Hospital Oslo, Norway
Marilyn Jones-Gotman, PhD Professor Department of Neurology and Neurosurgery Montreal Neurological Institute McGill...
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