Advanced Mass Spectrometry

PrefaceChapter 1 IntroductionChapter 2 Fundamentals 2.1 Ion Types 2.2 The Production of Ions 2.2.1 Ionization by Electron Impact 2.2.2 Chemical Ionization 2.2.3 Field Ionization 2.2.4 Collisional Activation (CA) or Collision Induced Dissociation(CID) 2.2.5 Metastable Ions 2.3 The Ion in a Mass Spectrometer 2.3.1 The Effect of a Magnetic Sector 2.3.2 The Effect of an Electric Sector 2.4 The Construction of a Mass Spectrometer 2.5 Ions with Deblocked Genetic Information 2.6 Primary Conditions for the Detection of Genetic Relationships between IonsChapter 3 Hardware 3.1 Single Focusing Mass Spectrometers 3.1.1 Magnetic Mass Spectrometers 3.1.2 Ion Kinetic Energy Spectrometry(IKES) 3.2 Double-Focusing Mass Spectrometers 3.2.1 Detection of Fragment Origin in the Second Field-Free Region 3.2.2 Detection of Origin and Fate of Ions in the First Field-Free RegionChapter 5 Ion-Genetic Relationships 5.1 Presentation 5.2 DefinitionsChapter 6 Structural and Mechanistic Applications 6.1 Detection of Fragmentation Pathways 6.2 Elucidation of Ion Structures 6.2.1 Deduction of Ion Structures by Interpretation of Fragmentation Pathways 6.2.2 Analysis of Ion Structures by Collisional Activation 6.2.3 Analysis of Isomerizations 6.3 Detection of Rearrangements 6.3.1 The McLafferty Rearrangement 6.3.2 Single Proton Transfers after Elimination of a Neutral Particle 6.3.3 Rearrangements with Substituent Group Shifts 6.4 Analysis of Rearrangements Involving Ring Reactions 6.4.1 Ring Closing Reactions 6.4.2 Ring Expanding Reactions 6.4.3 Ring Contracting Reactions 6.4.4 Ring Opening ReactionsChapter 7 Chemical and Biochemical Applications 7.1 Analysis of the Sequence in Oligomers 7.2 Test for Purity 7.3 Direct Analysis of Mixtures 7.3.1 Analysis of Mixtures by Detecting the Precursor Ions 7.3.2 Analysis of Mixtures by Detecting the Product Ions 7.3.3 Analysis of Mixtures of Isobaric Ions by High Resolution DADI/MIKE Spectrometry 7.3.4 Analysis of Mixtures of IsomericCompoundsReferencesIndex