This monograph represents the first comprehensive review of hormones in human amniotic fluid and includes data published up to and including 1980. Recently, more extensive use of amniocentesis for prenatal diagnosis and evaluation of fetal lung maturation has shown that amniotic fluid hormone measurements can aid in the diagnosis of fetal and placental abnormalities. The material is presented in two main sections dealing with steroid and protein hormones. The methods of identification and quantitation are delineated, and the findings are discussed in relation to the clinical conditions. In addition, particular attention has been directed towards up-to-date review of the sources, metabolism and transfer of human amniotic fluid hormones. The review is intended to serve the needs of clinicians, basic scientists and students, providing detailed information on human amniotic fluid hormones in order to improve patient care and indicate possibilities for further investigations. Ttibingen, January 1982 A.E. Schindler Contents Introduction A. 1 Origin of Human Amniotic Fluid . 2 B. C. Origin and Regulation of Steroids in Human Amniotic Fluid . 5 D. Methods of Isolation and Identification of Steroids in Human Amniotic Fluid 6 I. C , C , and C Steroids . 6 30 29 28 II. C Steroids 6 27 1. Cholesterol 6 2. Cholestanol . 6 3. ,::l7 -Cholestenol and ,::l8 -Cholestenol. 6 4. 7-Dehydrocholesterol and Desmosterol . 6 ,::l5_C Steroids. III. 7 21 1. Pregnenolone 7 2. 16cx-H ydroxypregnenolone. 7 3. 17cx-Hydroxypregnenolone.
Reihe
Sprache
Verlagsort
Verlagsgruppe
Illustrationen
1
1 s/w Abbildung
XII, 160 p. 1 illus.
Dateigröße
ISBN-13
978-3-642-81656-7 (9783642816567)
DOI
10.1007/978-3-642-81656-7
Schweitzer Klassifikation
A. Introduction.- B. Origin of Human Amniotic Fluid.- C. Origin and Regulation of Steroids in Human Amniotic Fluid.- D. Methods of Isolation and Identification of Steroids in Human Amniotic Fluid.- I. C30, C29, and C28 Steroids.- II. C27 Steroids.- III. ?5-C21 Steroids.- IV. ?4-C21 Steroids.- V. Pregnane Steroids.- VI. ?5-C19 Steroids.- VII. ?4-C19 Steroids.- VIII. Androstane Steroids.- IX. C18 Steroids.- E. Quantitation of Steroids in Human Amniotic Fluid.- I. C30, C29, and C28 Steroids.- II. C27 Steroids.- III. ?5-C21 Steroids.- IV. ?4-C21 Steroids.- V. Pregnane Steroids.- VI. 17-Hydroxycorticosteroids.- VII. 11-Hydroxycorticosteroids.- VIII. ?5-C19 Steroids.- IX. ?4-C19 Steroids.- X. Androstane Steroids.- XI. 17-Ketosteroids.- XII. C18 Steroids.- F. Steroid Conjugates in Human Amniotic Fluid.- I. C30, C29, und C28 Steroids.- II. C27 Steroids.- III. ?5-C21 Steroids.- IV. ?4-C21 Steroids.- V. 17-Hydroxycorticosteroids.- VI. Pregnane Steroids.- VII. ?5-C19 Steroids.- VIII. ?4-C19 Steroids.- IX. 17-Ketosteroids.- X. Estrogens.- G. Steroid Profiles in Human Amniotic Fluid and Distribution of Steroids in Several Compartments.- H. Transfer and Metabolism of Steroids in Human Amniotic Membranes.- I. Fate of Steroids Injected into the Amniotic Cavity.- J. Binding of Steroids in Human Amniotic Fluid.- K. Proteohormones in Human Amniotic Fluid.- I. Luteinizing Hormone (LH).- II. Follicle-Stimulating Hormone (FSH).- III. Human Chorionic Gonadotropin (HCG).- IV. Human Placental Lactogen (HPL).- V. Prolactin (Prl).- VI. Adrenocorticotropic Hormone (ACTH).- VII. Human Growth Hormone (HGH).- VIII. Somatomedin and Somatomedin C.- IX. Thyroid-Stimulating Hormone (TSH).- X. Thyroid Hormones.- XI. Parathyroid Hormone (PTH).- XII. Oxytocin.- XIII. Glucagon.- XIV.Insulin.- XV. Hypothalamic-Releasing Hormones.- XVI. Neurophysin.- XVII. ?-Endorphin and "Humoral Endorphin".- XVIII. ?-Melanocyte-Stimulating Hormone (?-MSH).- XIX. Conclusions.- Acknowledgments.- References.
