Anticancer Drugs Sourced from Marine Life

Name: Anticancer Drugs Sourced from Marine Life | Bionanotechnology, Nanomedicine and Phytochemicals
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Bionanotechnology, Nanomedicine and Phytochemicals

Ramasamy Santhanam Santhanam Ramesh Subbiah Balasundari Sheba R. David(Autor*in)

De Gruyter (Verlag)

1. Auflage

Erschienen am 22. August 2024

385 Seiten

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978-981-5256-05-5 (ISBN)

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Inhalt

Cover
Title
Copyright
End User License Agreement
Contents
Foreword
Preface
Introduction
INTRODUCTION
Approved Drugs Sourced from Marine Biota
Cancer as a Major Public Health Problem
Pathophysiology of Cancer
Anticancer Potential of Marine Organisms
Most Promising Marine Biota-Derived Anticancer Compounds for the Different Types of Human Cancer
Human Colon Cancer
Human Cervical Cancer
Blood Cancer
Mammary Cancer
Hepatic Cancer
Human Skin Cancer
Biogeography of Marine Invertebrate Species Yielding Anticancer Compounds
Major Constraints in the Development of Anticancer Drugs
CONCLUSION
Marine Bio-Chemical Diversity: Promising Anticancer Groups
INTRODUCTION
Promising Anticancer Marine Biodiversity
Marine Microalgae
Macroalgae (Seaweeds)
Mangrove Plants
Marine Invertebrates
Promising Anticancer Marine Biota-derived Chemical Diversity
Predicted Total Number of Secondary Metabolites in Marine Plants and Invertebrates
Anticancer Marine Chemical Classes
Polyphenols
Polysaccharides
Alkaloids
Peptides
Antibiotics
Anticancer Chemical Diversity of Marine Biota
CONCLUSION
Marine Biota-based Anticancer Drug Candidates in Pipeline
INTRODUCTION
APPROVED AND MARKETED ANTICANCER DRUGS DERIVED FROM MARINE SPONGES
Eribulin Mesylate (E7389, Halaven®)
Panobinostat (LBH-589, Farydak®)
APPROVED AND MARKETED ANTICANCER DRUGS DERIVED FROM MARINE MOLLUSKS/CYANOBACTERIA ASSOCIATION
Brentuximab Vedotin ((SGN-35, Adcetris®)
Polatuzumab Vedotin
Enfortumab Vedotin-Eifv (Padcev®)
Disitamab Vedotin
Tisotumab Vedotin-tftv (Tivdak®)
Belantamab Mafodotin-blmf (Blenrep®)
APPROVED AND MARKETED ANTICANCER DRUGS DERIVED FROM MARINE TUNICATES
Plitidepsin (Aplidin®)
Trabectedin (Yondelis®)
Lurbinectedin
MARINE BIOTA- DERIVED ANTICANCER COMPOUNDS IN CLINICAL TRIALS
ANTICANCER MARINE SPECIES IN CLINICAL TRIALS
PATENTED NEW CHEMICAL ENTITIES (NCES) WITH ANTICANCER ACTIVITIES FROM MARINE BIOTA
Limiting Factors in the Development and Approval of Drugs from Marine Biota
Significant Challenges in the Development and Approval of Marine Drugs
CONCLUSION
Anticancer Potential of Marine Plants
INTRODUCTION
Microalgae
Green Algae
Chlorella sp.
Dunaliella tertiolecta
BLUE-GREEN ALGAE
Anabaena sp.
Arthrospira platensis (= Spirulina platensis)
Calothrix sp.
Coleofasciculus sp.
Cyanobium sp.
Dapis sp.
Leptolyngbya halophila
Leptolyngbya mycoidea
Leptolyngbya fragilis
Leptolyngbya sp.
Leptothoe kymatousa , Leptothoe sithoniana and Leptothoe spongobia
Nodosilinea nodulosa
Lyngbya majuscula
Lyngbya polychroa
Lyngbya sp.
Microcystis aeruginosa
Moorea bouillonii (= Lyngbya boulloni)
Moorea producens
Nodularia spumigena
Nodularia sp. LEGE 06071
Nostoc commune
Nostoc linckia
Nostoc linckia and Nostoc spongioforme
Nostoc sp.
Nodosilinea nodulosa LEGE 06102
Okeania hirsuta
Okeania sp.
Phormidium sp.
Pseudanabaena curta
Pseudanabaena sp. LEGE 06144
Romeria gracilis
Schizothrix calcicola
Schizothrix sp.
Symploca hydnoides
Symploca sp.
Synechocystis salina
Synechocystis sp. PCC 6803
Synechococcus sp.
Golden-brown, and Yellow Algae
Isochrysis galbana
Prymnesium parvum
Yellow-Green Algae (Diatoms)
Chaetoceros simplex var. calcitrans ( = Chaetoceros calcitrans)
Cocconeis scutellum
Cylindrotheca closterium
Haslea karadagensis
Navicula salinicola ( = Navicula incerta)
Odontella aurita
Phaeodactylum tricornutum
Pseudo-nitzschia delicatissima
Skeletonema costatum
Skeletonema marinoi
Synedra acus
Thalassionema nitzschioides
Thalassiosira rotula
Thalassiosira rotula, Skeletonema costatum and Pseudo-nitzschia delicatissima
Vibrio ostrearius ( = Haslea ostrearia)
Dinoflagellates
Alexandrium andersoni
Alexandrium pseudogonyaulax ( = Goniodoma pseudogoniaulax) Alexandrium monilatum and Alexandrium hiranoi
Alexandrium minutum
Alexandrium ostenfeldii
Alexandrium peruvianum
Amphidinium carterae
Amphidinium operculatum AA60
Amphidinium sp. S1-36-5
Amphidinium sp. 12012-7-4A
Amphidinium sp. 1
Amphidinium sp. 2
Amphidinium sp. 3
Amphidinium sp. 5
Amphidinium sp. 7
Alexandrium tamarense
Azadinium sp.
Cripthecodinium chonii
Dinophysis acuminata
Dinophysis acuta
Dinophysis caudata
Dinophysis fortii, Dinophysis miles, Dinophysis norvegica, Dinophysis rotundataum and Dinophysis sacculus
Dinophysis tripos
Gambierdiscus australes
Gambierdiscus pacificus and Gambierdiscus toxicus
Gambierdiscus toxicus
Gonyaulax spinifera
Heterocapsa circularisquama
Heterocapsa triquetra
Karlodinium veneficum
Karenia mikimotoi ( = Gymnodinium mikimotoi)
Karenia selliformis ( = Gymnodinium selliforme)
Ostreopsis fattorussoi
Ostreopsis ovata
Ostreopsis siamensis
Phalacroma mitra ( = Dinophysis mitra) and Phalacroma rotundatum ( = Dinophysis rotundata)
Prorocentrum arenarium
Prorocentrum hoffmannianum ( = Prorocentrum belezeanum
Prorocentrum maculosum)
Prorocentrum concavum and Prorocentrum lima
Prorocentrum reticulatum
Symbiodinium sp.
Vulcanodinium rugosum
Red alga
Porphyridium cruentum ( = Porphyridium purpureum)
Macroalgae (Seaweeds)
Green algae
Brown algae
Fucus vesiculosus, Laminaria japonica, Alaria esculenta, Ascophyllum nodosum, Bifurcaria bifurcata and Sargassum muticum and Bifurcaria bifurcata
Carpodesmia tamariscifolia ( = Cystoseira tamariscifolia)
Colpomenia sinuosa and Sargassum prismaticum
Eisenia bicyclis
Ecklonia cava
Fucus vesiculosus
Ishige okamurae
Laminaria digitata
Laminaria japonica
Sargassum carpophyllum
Sargassum filipendula
Sargassum hemiphyllum
Sargassum sp.
Stypodium zonale
Undaria pinnatifida
Red algae
Amphiroa anceps
Champia feldmanni
Champia parvula
Chondrus armatus
Chondrus ocellatus
Chondrus, Gigartina, Eucheuma and Iridaea sp.
Cladosiphon okamrensis and Eucheuma cottonii
Eucheuma cottonii
Corallina mediterranea
Fucus vesiculosis
Gigartina pistillata
Gracilaria dominguensis
Grateloupia filicina
Laurencia papillosa
Lophocladia sp.
Palmaria palmata
Portieria hornemannii and Spyridia fusiformis
Seagrasses
Cymodocea serrulata
Halophila stipulaceae
Posidonia oceanica
Syringodium filiforme
Thalassia testudinum
Mangroves
Acanthus ilicifolius
Aegiceras corniculatum
Avicennia alba
Avicennia officinalis
Avicennia marina
Bruguiera cylindrica
Bruguiera gymnorrhiza
Bruguiera sexangular
Ceriops decandra
Ceriops tagal
Excoecaria agallocha
Heritieria fome
Heritiera littoralis
Ipomoea tuba
Nypa fruticans
Rhizophora apiculata
Rhizophora stylosa
Sonneratia apetala
Sonneratia caseolaris
Sonneratia paracaseolaris
Thalassodendron ciliatum
Xylocarpus granatum
Xylocarpus sp.
Halophytes
Salicornia europaea ( = Salicornia herbacea)
Salicornia freitagii
CONCLUSION
Anticancer Potential of Marine Sponges
INTRODUCTION
Anticancer Activity of Alkaloids of Marine Sponges
Aaptos aaptos
Aaptos suberitoides
Aaptos sp.
Aplysina aerophoba
Arenosclera brasiliensis
Batzella sp.
Dragmacidon sp.
Ectenascidia turbinata
Fascaplysinopsis reticulata
Fascaplysinopsis sp.
Kirkpatrickia variolosa
Latrunculia (Latrunculia) brevis
Leucetta chagosensis
Monanchora arbuscula
Monanchora pulchra
Monanchora unguiculata
Oceanapia sagittaria
Pachychalina alcaloidifera
Pseudoceratina purpurea ( = Dendrilla verongiformis)
Pseudocerarina sp. (= Psammaplysilla sp.)
Stylissa massa ( = Hymeniacidon aldis)
Xestospongia sp. 1 and 2
Zyzzya fuliginosa
Anticancer Activity of Terpenes of Marine Sponges
Aka (Siphonodyctio) corallifagum
Callyspongia (Callyspongia) siphonella ( = Siphonochalina siphonella)
Dactylospongia elegans
Diacarnus megaspinorhabdosa
Dysidea villosa
Fasciospongia cavernosa
Geodia japonica
Haliclona sp.
Hyrtios erectus
Hyrtios reticulatus
Hyrtios sp.
Jaspis stellifera
Jaspis sp.
Niphates olemda
Psammocinia sp.
Phorbas gukhulensis
Rhabdastrella globostellata
Sarcotragus sp. 1
Sarcotragus sp. 2
Scalarispongia scalaris ( = Cacospongia scalaris)
Siphonochalina sp.
Smenospongia aurea
Spongia sp.
ANTICANCER ACTIVITY OF PEPTIDES OF MARINE SPONGES
Amphibleptula sp.
Hemiasterella vasiformis var. ,minor ( = Hemiasterella minor)
Geodia tylastra ( = Geodia corticostylifera)
Hemiastrella minor
Lendenfeldia chondrodes ( = Fasciospongia chondrodes)
Pachymatisma johnstonia
Smenospongia aurea
Stylissa sp.
Theonella swinhoei
Anticancer Activity of Lipids of Marine Sponges
Agelas mauritiana
Aplysilla glacialis
Axinella infundibuliformis
Dysidea sp.
Dactylospongia elegans
Ircinia echinata
Leucetta microraphis
Monanchora sp.
Oceanapia incrustata ( = Rhizochalina incrustata)
Petrosia sp.
Stelletta sp.
Theonella swinhoei
Theonella sp.
Topsentia sp.
Xestospongia testudinaria
Xestospongia sp. 1
Xestospongia sp. 2
Xestospongia sp. 3
ANTICANCER ACTIVITY OF POLYKETIDES OF MARINE SPONGES
Axinella sp.
Cacospongia mycofijiensis
Candidaspongia sp.
Chondrosia corticata
CHONDROPSIS SP.
Discodermia dissoluta
Fascaplysinopsis sp.
Forcepia sp.
Halichondria (Halichondria) okadai
Hyatella sp.
Leiodermatium sp.
Lissodendoryx sp.
Lithoplocamia lithistoides
Negombata magnifica
Plakortis angulospiculatus
Plakortis halichondrioides
Spongia sp.
Theonella sp.
Anticancer Activity of Miscellaneous Compounds of Marine Sponges
Aphrocallistes beatrix
Axinella brevistyla
Callyspongia sp.
Coscinoderma mathewsi
Crambe crambe
Cymbastela cantharella
Dactylospongia metachromia, ( = Hippospongia metachromia)
Discodermia calyx
Discodermia dissoluta
Haliclona (Soestella) mucosa
Hyrtios erectus
Ianthella sp.
Ircinia ramosa
Mycale hentscheli
Mycale sp.
Pachastrissa sp.
Petrosia sp.
Plakinastrella sp.
Plakortis angulospiculatus
Plakortis sp.
Pseudocerarina sp. 1 ( = Psammaplysilla sp.)
Pseudoceratina sp. 2 (= Psammaplysilla sp.)
Tectitethya crypta ( = Cryptotheca crypta)
Tedania sp.
Theonella sp.
Trachycladus spinispirulifera ( = Spirastrella spinispirulifera)
Xestospongia sp.
CONCLUSION
Anticancer Potential of Marine Cnidarians
INTRODUCTION
Anticancer Compounds of Marine Hydrozoans (Phylum: Cnidaria
Class: Hydrozoa) and their Action Mechanisms
Abylopsis eschscholtzii
Aeginura Grimaldi, Aegina citrea, Colobonema sericeum and Arctapodema sp.
Aequorea aequorea
Chlorohydra viridissima
Crossota rufobrunnea
Halecium muricatum and Halecium beanie
Halicreas minimum and Pantachogon Haeckel
Macrorhynchia philippina
Physalia physalis
Thuiaria breitfussi
Anticancer Compounds of Marine Scyphozoans (Class: Scyphozoa) and their Action Mechanisms
Atolla vanhoeffeni
Aurelia aurita
Cassiopea xamachana
Chrysaora quinquecirrha
Cotylorhiza tuberculata
Cyanea capillata and Cyanea lamarckii
Cyanea capillata
Cyanea nozakii
Nemopilema nomurai
Pelagia noctiluca
Rhizostoma pulmo
Anticancer Compounds of Marine Cubozoans (Class: Cubozoa) and their Action Mechanisms
Chiropsalmus quadrigatus
Chironex fleckeri
Anticancer Compounds of Marine Octocorals (soft corals) (Class: Anthozoa) and their Action Mechanisms
Acalycigorgia inermis
Alcyonium paessleri
Alcyonium patagonicum
Alertigorgia sp.
Bellonella albiflora
Briareum asbestinum
Briareum excavatum
Briareum sp.
Carijoa riisei ( = Telesto riisei)
Carijoa sp. and Lophogorgia sp.
Carijoa sp.
Clavularia viridis
Clavularia inflata
Clavularia koellikeri
Clavularia sp.
Dendronephthya gigantea
Dichotella gemmacea
Echinomuricea sp. 1
Echinomuricea sp. 2
Eunicea laciniata
Eunicea mammosa
Eunicea pinta
Eunicea succinea
Eunicella verrucosa
Gersemia fruticosa
Isis hippuris
Junceella juncea
Lemnalia philippinensis
Lemnalia tenuis
Leptogorgia punicea
Leptogorgia sarmentosa
Lobophytum crassum
Lobophytum hedleyi
Lobophytum michaelae
Muricella sp.
Nephthea sp.
Paraminabea acronocephala
Paramuricea sp.
Plexaurella grisea
Sarcophyton crassocaule
Sarcophyton trocheliophorum
Scleronephthya pallida
Sinularia capillosa
Sinularia flexibilis
Sinularia gardineri
Silularia gibberosa
Sinularia inelegans
Sinularia leptoclados
Sinularia sp.
Solenopodium excavatum
Subergorgia suberosa
Virgularia juncea
Xenia blumi
Xenia elongata
Xenia faraunensis
Xenia florida
Xenia novae-britanniae
Xenia umbellata
Xenia sp.
ANTICANCER COMPOUNDS OF MARINE STONY AND BLACK CORALS (CLASS: ANTHOZOA) AND THEIR ACTION MECHANISMS
Epizoanthus sp.
Montipora digitata
Montipora sp. 1
Montipora sp. 2
Palythoa toxica
Palythoa liscia
Tubastrea faulkneri
Anticancer Compounds of Sea Anemones (Class: Anthozoa) and their Action Mechanisms
Actinia equina
Aiptasia mutabilis
Anemonia sulcata
Bunodosoma caissarum
Bunodeopsis globulifera
Radianthus crispa ( = Heteractis crispa
Radianthus macrodactylus)
Sagartia rosea
Urticina piscivora
CONCLUSION
Anticancer Potential of Marine Bryozoans
INTRODUCTION
Anticancer and Cytotoxic Metabolites of Marine Bryozoans
Anticancer Alkaloid Compounds of Marine Bryozoans
Amathia convoluta
Amathia tortuosa
Amathia wilsoni
Aspidostoma giganteum
Biflustra perfragilis
Caulibugula intermis
Chartella papyracea
Cryptosula pallasiana
Flustra foliacea
Paracribricellina cribraria
Pterocella vesiculosa
Securiflustra securifrons
Tegella spitzbergensis
Terminoflustra (Chartella) membranaceotruncata
Virididentula (Bugula) dentata
Anticancer Lactone Compounds of Marine Bryozoans
Bugula neritina
Myriapora truncata
Cryptosula pallasiana
CONCLUSION
Anticancer Potential of Marine Shellfish
INTRODUCTION
MARINE CRUSTACEANS
Shrimps
Litopenaeus vannamei
Penaeus indicus
Lobster and Shrimp Shell Wastes
Marine Crabs
Calappa calappa
Chionoecetes opilio
Portunus segnis
Serratia marcescens
Chitosan Derived from Crab Shell Wastes
MARINE MOLLUSCS
Marine Bivalves
Atactodea striata
Bathymodiolus thermophilus
Crassula aequilatera
Crassostrea gigas
Meretrix lusoria
Mytilus edulis
Paphia malabarica
Paphies donacina
Spisula murchisoni ( = Mactra murchisoni)
Spisula polynyma ( = Mactromeris polynima)
Tegillarca granosa
Villorita cyprinoides
MARINE GASTROPODS
Terpenes and Steroids
Aplysia angasi ( = Aplysia dactylomela)
Aplysia depilans
Aplysia fasciata
Aplysia kurodai
Aplysia oculifera
Aplysia punctata
Austrodoris kerguelenensis
Chelynotus semperi
Chromodoris obsoleta ( = Goniobranchus obsoletus)
Chromodoris inornata ( = Chromodoris aspersa)
Dicathais orbita
Dolabella auricularia
Elysia subornata
Jorunna funebris
Leminda millecra
Phidiana militaris
Phyllidia coelestis
Pleurobranchus albiguttatus and Pleurobranchus forskalii
Reticulidia fungia
Trimusculus costatus
Trimusculus peruvianus
Peptides and Depsipeptides
Dolabella auricularia
Onchidium sp.
Pleurobranchus forskalii
Philinopsis speciosa
Polyketides
Aplysia kurodai
Chromodoris lochi
Chromodoris lochi, Chromodoris elisabethina, Chromodoris kuiteri, Chromodoris annae, and Chromodoris magnifica
Dolabella auricularia
Glossodoris quadricolor (= Chromodoris quadricolor)
Hexabranchus sanguineus
Kelletia kelletii
Onchidium sp.
Peltodoris atromaculata
Nitrogen Containing Compounds
Aplysia kurodai
Bursatella leachii and Stylocheilus longicauda
Coriocella nigra
Staurosporine analogues
Dolabella auricularia
Lamellaria sp.
Roboastra tigris
Tambja ceutae
Turbo coronatus
Turbo stenogyrus
Tylodina perversa
Cephalopods
Sepiella inermis ( = Sepiella maindroni)
Uroteuthis (Photololigo) duvaucelii (=Loligo duvaucelii)
Octopus vulgaris
ECHINODERMS
Starfish
Acanthaster planci
Anthenea aspera
Anthenea chinensis
Anthenea sibogae
Archaster typicus
Asterias amurensis
Asterina pectinifera
Asteropsis carinifera
Astropecten polyacanthus
Astropecten monacanthus
Certonardoa semiregularis
Choriaster granulatus
Craspidaster hesperus
Ctenodiscus crispatus
Culcita novaeguinea
Echinaster luzonicus
Henricia leviuscula
Hippasteria phrygiana
Leptasterias ochotensis
Lethasterias fusca
Narcissia canariensis
Pentaceraster gracilis
Brittle Stars
Ophiocoma erinaceus
Ophioderma longicauda
Ophiocoma scolopendrina
Ophiomastix mixta
Ophioplocus japonicus
Ophiura sarsii, Ophiura ooplax and Gorgonocephalus cf. eucnemis
Sea Urchins
Diadema savignyi
Mesocentrotus nudus and Scaphechinus mirabilis
Paracentrus lividus
Strongylocentrotus intermedius
Strongylocentrotus nudus
Strongylocentrotus purpuratus
Toxopneustes pileolus and Tripneustes gratilla
Crinoids
Comantheria rotula
Comanthus sp.
Comatula rotalaria
Sea Cucumbers
Apostichopus (Stichopus) japonicus ( = Stichopus japonicus)
Cucumaria frondosa
Cucumaria japonica
Cucumaria okhotensis
Holothuria atra
Holothuria leucospilota
Holothuria leucospilota, Holothuria parva and Holothuria scabra
Holothuria nobilis
Mensamaria intercedens
Pearsonothuria graeffei
Pentacta quadrangulari
Psolus fabricii and Stichopus chloronotus
Stichopus chloronotus
Stichopus japonicus
Stichopus variegatus
CONCLUSION
Anticancer Potential of Marine Chordates
INTRODUCTION
Tunicates
Aplidium altarium
Aplidium caelestis
Aplidium conicum
Aplidium cyaneum
Aplidium densum
Aplidium elegans and Ciona edwardsii
Aplidium glabrum
Aplidium glabrum
Aplidium longithorax
Aplidiopsis confluata
Ascidia mentula
Botryllus tuberatus
Botryllus tyreus
Ciona edwardsii
Clavelina phlegraea
Cnemidocarpa bicornuta
Cystodytes dellechiajei
Cystodytes violatinctus
Cystodytes sp.
Didemnum granulatum
Didemnum lahillei, Aplidium glabrum, and Molgula manhattensis
Didemnum molle
Didemnum moseleyi
Didemnum obscurum
Didemnum proliferum
Didemnum psammatodes
Didemnum. rubeum
Didemnum sp.
Didemnum sp. 1
Didemnum sp. 2
Didemnum sp. 3
Diplosoma virens
Diplosoma sp.
Distaplia regina
Eudistoma gilboviride
Eudistoma toealensis
Eudistoma vannamei
Eudistoma sp.
Halocynthia papillosa and Halocynthia roretzi
Leptoclinides dubius
Lissoclinium badium
Lissoclinium notti
Lissoclinum sp. 1
Lissoclinum sp. 2
Microcosmus vulgaris
Perophora namei
Phallusia fumigata
Phallusia nigra
Policitor adriaticus
Polyandrocaroa zorritensis
Polycarpa aurata
Pseudodistoma megalarva
Sidnyum turbinatum
Stolonica sp.
Syncarpa oviformis
Synoicum adareanum
Synoicum pulmonaria
Synoicum sp.
Trididemnum cyclops
Unidentified tunicate sp. 1
Unidentified tunicate sp. 2
Unidentified tunicate sp. 3
Unidentified tunicate sp. 4
MARINE FISHES
Elasmobranchs
Centroscymnus coelepis
Prianace glauca
Squalus acanthias
Okamejei kenojei
Teleosts
Epinephelus coioiodes
Epinephelus lanceolatus
Exocoetus volitans
Gadus morhua, Lethrinus atlanticus, Micromesistius poutassou, Puronectes platessa, and Salmo salar
Lates calcarifer
Nemipterus japonicus
Onchorhnchus keta
Pardachirus marmoratus
Platycephalus fuscus
Plicofollis dussumieri ( = Tachysaurus dussumieri)
Setipinna taty
Syngnathus acus
Thunnus tonggol
CONCLUSION
REFERENCE
REFERENCE
Subject Index
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