Myelin

Part 1. Myelination in neural development and regeneration.- 1. Cellular signal-regulated Schwann cell myelination and remyelination.- 2. Regulatory mechanism of peripheral nerve myelination by glutamate-induced signaling.- 3. Cytoskeletal signal-regulated oligodendrocyte myelination and remyelination.- 4. Activity-dependent myelination.- 5. Heterogeneity of oligodendrocytes and their precursor cells.- Part 2. Specialized structures along the myelinated nerve fibers.- 6. Functional domains in myelinated axons.- 7. Physiology of myelinated nerve conduction and pathophysiology of demyelination.- 8. Under the ECM dome: the physiological role of the perinodal extracellular matrix as an ion diffusion barrier.- 9. Oligodendrocyte physiology modulating axonal excitability and nerve conduction.- 10. Mitochondrial dynamics in physiology and pathology of myelinated axons.- 11. The role of sulfatides in axon-glia interactions.- 12. Structures and molecular composition of Schmidt-Lanterman incisures.- Part 3. Myelin pathology in the central nervous system.- 13. Pelizaeus-Merzbacher disease: molecular and cellular pathologies and associated phenotypes.- 14. Multiple sclerosis.- 15. Visualization of myelin for the diagnosis and treatment monitoring of multiple sclerosis.- 16. Roads to formation of normal myelin structure and pathological myelin structure.- 17. Therapeutic strategies for oligodendrocyte-mediated remyelination.- 18. Brain tumors of glial cell origin.- Part 4. Myelin pathology in the peripheral nervous system.- 19. Schwann cell and the pathogenesis of Charcot-Marie-Tooth disease.- 20. Guillain- Barré Syndrome.- 21. Chronic inflammatory demyelinating polyneuropathy.- 22. Schwann cells as crucial players in diabetic neuropathy.- 23. Drug-induced demyelinating neuropathies.- 24. Transthyretin amyloid neuropathy: the Schwann cell hypothesis.