Genomics and Bioinformatics

Preface; Acknowledgements; Design and conventions of this book; 1. Introduction - working with the molecules of life in the computer; 2. Gene technology - cutting DNA; 3. Gene technology - knocking genes down; 4. Gene technology - amplifying DNA; 5. Human disease - when DNA sequences are toxic; 6. Human disease - iron imbalance and the iron responsive element; 7. Human disease - cancer as a result of aberrant proteins; 8. Evolution - what makes us human?; 9. Evolution - resolving a criminal case; 10. Evolution - the sad case of the Tasmanian tiger; 11. A function to every gene - termites, metagenomics and learning about the function of a sequence; 12. A function to every gene - royal blood and order in the sequence universe; 13. A function to every gene - a slimy molecule; 14. Information resources - learning about flu viruses; 15. Finding genes - going ashore at CpG islands; 16. Finding genes - in the world of snurps; 17. Finding genes - hunting for the distant RNA relatives; 18. Personal genomes - the differences between you and me; 19. Personal genomes - what's in my genome?; 20. Personal genomes - details of family genetics; Appendix I. Brief Unix reference; Appendix II. A selection of biological sequence analysis software; Appendix III. Short Perl reference; Appendix IV. Brief introduction to R; Index.