3D Bioprinting from Lab to Industry

Name: 3D Bioprinting from Lab to Industry
Brand: Wiley
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Prosenjit Saha Sabu Thomas Jinku Kim Manojit Ghosh(Herausgeber*in)

Wiley (Verlag)

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Erschienen am 2. Juli 2024

528 Seiten

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Beschreibung

A complete overview of bioprinting, from fundamentals and essential topics to recent advances and future applications

Additive manufacturing, also known as 3D printing, is one of the most transformative technological processes to emerge in recent decades. Its layer-by-layer construction method can create objects to remarkably precise specifications with minimal waste or energy consumption. Bioprinting, a related process that employs cells and biomaterials instead of man-made substances or industrial materials, has a range of biomedical and chemical uses that make it an exciting and fast-growing area of research.

3D Bioprinting from Lab to Industry offers a cutting-edge overview of this topic, its recent advances, and its future applications. Taking an interdisciplinary approach to a flourishing research field, this book exceeds all existing treatments of the subject in its scope and comprehensiveness. Moving from fundamental principles of the technology to its immense future potential, this is a must-own volume for scientists looking to incorporate this process into their research or product development.

3D Bioprinting from Lab to Industry readers will also find:

Treatment of printing parameters, surface topography requirements, and much more
Detailed discussion of topics including 5D printing in the medical field, dynamic tuning, the multi-material extrusion approach, and many others
A complete account of the bioprinting process, from lab requirements to commercialization

3D Bioprinting from Lab to Industry is ideal for researchers-graduate and post-doctoral scholars-in the areas of materials science, biomedical engineering, chemical engineering, biotechnology, and biochemistry.

Prosenjit Saha, PhD, is an Associate Professor in the Centre for Interdisciplinary Sciences at the JIS Institute of Advanced Studies and Research (JISIASR) at the JIS University, India

Sabu Thomas, PhD, is a Professor in the School of Energy Materials, School of Nanoscience and Nanotechnology, School of Polymer Science and Technology, School of Chemical Science and International and Inter University Centre for Nanoscience and Nanotechnology (IIUCNN), Mahatma Gandhi University, Kottayam, India and a Distinguished Professor of Department of Chemical Sciences, University of Johannesburg, Doornfontein, Johannesburg, South Africa. He is also the Chairman of TrEST Research Park, Trivandrum, Kerala, India

Jinku Kim, PhD, is a Professor in the Department of Biological and Chemical Engineering at Hongik University, Republic of Korea.

Manojit Ghosh, PhD, is a Professor in the Department of Metallurgy and Materials Engineering in the Indian Institute of Engineering Science and Technology, India

Weitere Details

Weitere Ausgaben

Inhalt

Cover
Title Page
Copyright Page
Contents
List of Contributors
Foreword
Chapter 1 Introduction of 3D Printing and Different Bioprinting Methods
1.1 Introduction of 3D Printing: Principles and Utility
1.2 Ink Preparation and Printability
1.3 Methods of Bioprinting in Fabrication and Tissue Engineering
1.3.1 Laser-Based Printing
1.3.1.1 Types of Laser Printing
1.3.2 Extrusion-Based Printing
1.3.3 Droplet Printing
1.3.4 Inkjet-Based Printing
1.3.5 Stereolithography 3D Printing
1.4 Scaffold Modeling and G Coding
1.4.1 Scanning Technology
1.4.2 CT Imaging
1.4.3 MRI Scanning
1.4.4 Preferred Accuracy Parameters for Scanning
1.4.5 Biomodeling Process for RP
1.5 Applications and Utility in Large-Scale Manufacturing
1.5.1 Bone
1.5.2 Cartilage
1.5.3 Skin
1.5.4 Vascular Grafts
1.5.5 Heart
1.5.6 Lungs
1.5.7 Liver
1.5.8 Kidney and Urethra
1.5.9 Brain and Spinal Cord
1.5.10 Cornea
1.5.11 Therapeutics
1.6 Complications and Troubleshooting
1.6.1 Laser-Based Printing
1.6.2 Inkjet-Based Printing
1.6.3 Extrusion-Based Printing
1.6.4 Droplet Printing
1.6.5 Stereolithography 3D Printing
References
Chapter 2 Cellular Requirements and Preparation for Bioprinting
2.1 Introduction
2.2 Types of Bioprinting
2.2.1 Inkjet-Assisted Printing
2.2.2 Extruder-Assisted Printing
2.2.3 Laser-Assisted Bioprinting
2.3 Features Required for Bioprinting with Cells
2.3.1 Sterility Parameters
2.3.2 Printing Speed and Pressure
2.3.3 pH and Osmotic Condition
2.3.4 Hydrogel Generation
2.3.4.1 Natural Polymers
2.3.4.2 Synthetic Polymers
2.3.5 Culture Duration and Conditions
2.3.6 Rheological Properties
2.4 Bioprinting Methodologies for Cell Expansion and Proliferation
2.5 The Impact of Bioprinting Process Conditions on Phenotype Alterations
2.5.1 Bioprinting Techniques for Stem Cell Differentiation
2.5.1.1 Bioprinting Strategies for Cellular Environment Alterations
2.5.1.2 Bioprinting Strategies for Cell Behavior Modulation
2.5.1.3 Bioprinting Strategies for Genetic Modulationand Transcriptomics Variation
2.5.2 Bioprinting Techniques for Tumorigenic Differentiation
2.5.2.1 Bioprinting Strategies for Oncogenic Cell Growth
2.5.2.2 Bioprinting Strategies for the Development of Tumor Models
2.6 Discussion
2.7 Conclusion
2.8 Future Prospects
References
Chapter 3 3D Bioprinting: Materials for Bioprinting Bioinks Selection
3.1 Introduction
3.2 Bioprinting Materials
3.2.1 Biomaterials
3.2.2 Cells
3.2.3 Biomolecules or Additive Molecules
3.2.4 Hydrogels
3.3 Bioinks Selectivity Guide
3.3.1 Printability of Materials
3.3.2 Material Biocompatibility
3.3.3 Structural Properties
3.3.4 Materials Degradation
3.3.5 Biomimicry
3.4 Classification of Bioprinting Materials
3.4.1 According to Material Type
3.4.1.1 Polymers
3.4.1.2 Nanocomposites
3.4.1.3 Nanoparticles
3.4.2 According to Cell Dependence
3.4.2.1 Cell-basedBioinks
3.4.2.2 Cell-FreeBioinks (Biomaterial Inks)
3.5 3D Bioprinting Methods According to the Type of the Bioinks
3.5.1 Extrusion-Based 3D Bioprinting
3.5.2 Inkjet 3D Bioprinting
3.5.3 Stereolithography 3D Bioprinting
3.5.4 Laser-Based 3D Bioprinting
3.5.5 Bioplotting
3.6 Bioinks Selection According to Biomedical Application
3.7 Multicomponent Bioinks
3.8 Future Prospects
References
Chapter 4 Printed Scaffolds in Tissue Engineering
4.1 Introduction
4.2 Biomedical Application of 3D Printing
4.2.1 Implants and Scaffolds
4.2.2 Drug Delivery/Drug Modeling Application
4.2.3 Applications of 3D Printed Scaffolds During COVID-19
4.3 Tissue Engineering: Emerging Applications by 3D Printing
4.3.1 Cartilage Tissue Engineering by Printed Scaffolds
4.3.2 Liver Tissue Engineering by Printed Scaffolds
4.3.3 Nerve Tissue Engineering by Printed Scaffolds
4.3.4 Cardiac Tissue Engineering by Printed Scaffolds
4.4 Conclusions
References
Chapter 5 Printability and Shape Fidelity in Different Bioprinting Processes
5.1 Introduction
5.2 Fundamentals of Printability
5.3 Bioprinting Techniques and Printability
5.3.1 Extrusion-Based Bioprinting
5.3.2 Inkjet-Based Bioprinting
5.3.3 Stereolithography-Based Bioprinting (SL)
5.4 Shape Fidelity
5.4.1 Shape Fidelity in Planar Structures
5.4.2 Shape Fidelity in Multilayered Structures
5.4.3 Characterization Approaches
5.4.3.1 Rheological Characterization
5.4.3.2 Mechanical Characterization
5.4.3.3 Swelling Test
5.4.3.4 Viability Characterization
5.4.3.5 Bioprinting Procedure
5.5 Case Studies and Applications
5.6 Conclusion
References
Chapter 6 Advancements in Bioprinting for Medical Applications
6.1 Introduction
6.2 Bioprinting for Drug Development and Testing
6.2.1 Overview
6.2.2 3D Bioprinted Organoids
6.2.3 Organ-on-a-Chip/Microfluidic Systems
6.2.4 Bioprinted Models for Cancer Research
6.2.5 3D Bioprinting for Immunotherapy and Cell Therapy
6.3 Bioprinting in Tissue Engineering, Regenerative Medicine, and Organ Transplantation
6.3.1 Ocular Tissue Engineering
6.3.1.1 Retina
6.3.1.2 Cornea
6.3.2 Neural Tissue
6.3.3 Skin
6.3.3.1 Disease and Pharmaceutical Studies
6.3.3.2 Wound Healing
6.3.3.3 Reconstructive Surgery
6.3.4 Cartilage and Bone
6.3.4.1 Cartilage Printing Modalities
6.3.4.2 Cartilage Regeneration
6.3.5 Vascular Tissue
6.3.6 Cardiac Tissue Engineering
6.3.7 Pancreas
6.3.7.1 Modulating Bioink Formulation to Enhance Tissue Viability
6.3.7.2 Controlling Other Printing Parameters to Enhance Tissue Viability
6.3.7.3 Using Printed Models to Study Pancreatic Cancer
6.3.8 Liver
6.3.8.1 Developing Suitable In Vitro Models
6.3.9 Lungs
6.3.9.1 Developing Suitable In Vitro Models
6.3.9.2 Application of 3D Construct
6.3.10 Renal/Kidney
6.3.10.1 Printing Parameters Affecting the Viability of Printed Model
6.3.10.2 Applications of 3D-PrintedModel
6.3.11 Composite Tissues
6.3.12 Other Tissues
6.4 Bioprinting in Tissue: Challenges, Barriers to Clinical Translation, and Future Directions
6.4.1 Introduction
6.4.1.1 Current Challenges in Organ Transplantation
6.4.1.2 Potential of Bioprinted Organs for Transplantation
6.4.1.3 Challenges and Limitations in Bioprinting Tissues and Organs
6.4.2 Insight on Barriers to Clinical Translation of Bioprinting Technology
6.4.3 Future Directions
6.5 Conclusions
Acknowledgments
References
Chapter 7 4D-Printed, Smart, Multiresponsive Structures and Their Applications
7.1 Introduction
7.2 4D-Printing Technologies
7.3 Biomaterials for 4D Bioprinting
7.3.1 Water-Responsive Polymers
7.3.2 Temperature-Responsive Polymers (Hydrogels)
7.3.3 Electrical/Magnetic-Responsive Polymers
7.4 Biomedical Applications for 4D Bioprinting
7.4.1 Limitations of 3D Bioprinting
7.4.2 Biomedical Applications of 4D Printing
7.4.3 Scaffold Preparation
7.4.4 Drug Delivery
7.4.5 Sensors
7.4.6 Medical Devices
7.4.7 Tissue Engineering and Organ Regeneration
7.5 Future Perspectives
References
Chapter 8 Toxicity Aspects and Ethical Issues of Bioprinting
8.1 Introduction
8.2 Toxicity Issues in Bioprinting
8.2.1 Cell Harvesting and Culture
8.2.2 Aseptic Techniques in Bioprinting
8.3 Ethical Issues in Bioprinting
8.3.1 Purpose
8.3.2 Cell Source
8.3.3 Data and Consent
8.3.4 Safety
8.3.5 Cost and Equity
8.3.6 Reproductive Organs
8.4 Issues in Clinical Trials
8.4.1 Personalized Treatment
8.4.2 Inability to Withdraw or Access Alternate Treatments
8.5 Legal Issues in Bioprinting
8.5.1 Intellectual Property Rights and Product Classification
8.5.2 Lack of Regulatory Guidelines
8.6 Conclusion
References
Chapter 9 Planning Bioprinting Project
9.1 Introduction
9.2 Background: Image Capturing and Solid Model Preparation of Virtual Anatomical Model for 3D Printing
9.2.1 Other Imaging Techniques
9.2.2 Digital Process for STL Generation
9.2.3 Blueprint Modeling
9.2.4 CAD-Based Systems Characteristics
9.2.5 Image-Based Systems
9.2.6 Freeform Systems
9.2.7 Designs Using Implicit Surfaces
9.2.8 Space-Filling Curves
9.2.9 Planning of Toolpath for Bioprinting
9.2.10 Cartesian Form Toolpath Planning
9.2.11 Parametric Form in Toolpath Planning
9.2.12 Bioprinting Methods
9.2.12.1 Extrusion Bioprinting
9.2.12.2 Inkjet Printing
9.2.12.3 Laser-AssistedPrinting
9.3 Conclusion
References
Chapter 10 Computational Engineering for 3D Bioprinting: Models, Methods, and Emerging Technologies
10.1 Introduction
10.2 Fundamentals of Numerical Methods in Bioprinting
10.2.1 Finite Element Analysis
10.2.2 Computational Fluid Dynamics
10.2.3 Agent-Based Modeling
10.2.4 Lattice Boltzmann Method
10.2.5 Molecular Dynamics
10.3 Application of Machine Learning for 3D Bioprinting
10.4 Summary
References
Chapter 11 Controlling Factors of Bioprinting
11.1 Introduction
11.2 Factors Influencing the Printability of Hydrogel Bioink
11.2.1 Extrudability
11.2.2 Filament Type
11.2.3 Shape Fidelity
11.2.4 Optimization of Printing Parameters
11.3 Bioink Formulation
11.4 Influence of Printing Process on Cell Behavior
11.5 Importance of Patterning and Surface Topography
11.5.1 Importance of Patterning with 3D Bioprinting
11.5.2 Effects of Patterning
11.5.3 Challenges of Patterning
11.5.4 Influence of Surface Topography with 3D Bioprinting
11.5.5 Effects of Surface Topographical Features
11.6 Contact Guidance and Directional Growth of Cells
11.6.1 2D Topographic Cues
11.6.2 3D Topographic Cues
11.7 Cell Viability and Mitigation Process
11.7.1 Inkjet-Based Bioprinting
11.7.2 Extrusion-Based Bioprinting
11.7.3 Laser-Based Bioprinting
11.7.4 Stereolithography-Based Bioprinting
11.8 Possible Mitigation Techniques
11.9 Conclusion
References
Chapter 12 In Situ Bioprinting
12.1 Introduction
12.2 Advantages of In Situ Bioprinting
12.2.1 Precision in Cellular Deposition
12.2.2 Enhanced Integration with Host Tissue
12.2.3 High-Fidelity Replication of the Extracellular Environment
12.2.4 Reduced Immune Response
12.2.5 Regulatory Requirements
12.2.6 Potential for Personalized Medicine
12.3 In Situ Bioprinting Technologies
12.3.1 Brief Review of 3D Bioprinting Methods
12.3.2 Adaptations for In Situ Applications
12.3.2.1 Automated In Situ Bioprinters
12.3.2.2 Semiautomated In Situ Bioprinters
12.3.2.3 Handheld In Situ Bioprinters
12.4 Bioinks and Biomaterials for In Situ Bioprinting
12.4.1 Overview
12.4.2 Engineering Consideration
12.4.2.1 Photocrosslinking
12.4.2.2 Biocompatibility and Biomimicry
12.4.2.3 Mechanical Properties
12.5 In Situ Approaches for Tissue Regeneration
12.5.1 Cartilage and Bone Regeneration
12.5.2 Skeletal Muscle Regeneration
12.5.3 Skin and Wound Regeneration
12.5.4 Dental Pulp Regeneration
12.6 Future Directions
12.6.1 4D Bioprinting
12.6.2 Open-Source Collaboration
12.6.3 Integration with Machine Learning
12.7 Conclusion
Acknowledgments
References
Chapter 13 Importance of Machine Learning in 3D Bioprinting
13.1 Introduction
13.2 3D Bioprinting
13.2.1 Fundamentals of 3D Bioprinting
13.2.2 Materials and Technologies in 3D Bioprinting
13.2.2.1 Different Materials in 3D Bioprinting
13.2.2.2 Different Technologies/Techniques in 3D Bioprinting
13.2.3 Application of 3D Bioprinting
13.3 Machine Learning in 3D Bioprinting
13.3.1 3D Bioprinting Process Using ML
13.3.2 Application of ML in 3D Bioprinting
13.4 Challenges in 3D Bioprinting Process Using ML
13.5 Future Outlook
13.6 Summary and Conclusion
References
Chapter 14 Advanced Bioprinting for the Future
14.1 Introduction
14.2 Electrospinning and Bioprinting
14.3 4D Printing
14.4 5D and 6D Printing
14.5 Organ Printing
14.6 Vascularized Organ on a Chip
14.7 Multimaterial Bioprinting
14.8 Printing in Microgravity
14.9 In Vivo Bioprinting
14.10 Biohybrid Robots
14.11 Conclusion and Future Perspectives
References
Chapter 15 Nanomaterials for Designing Functional Properties of Bioinks
15.1 3D-Bioprinting
15.1.1 Bioinks for 3D-Bioprinting
15.1.2 Designing of Functional Bioinks
15.1.2.1 Desirable Properties of Bioinks
15.1.2.2 Limitations of Bioinks
15.2 Designing Functional Bioinks Using Nanoscale Biomaterials
15.2.1 Types of Nano-Biomaterials
15.2.1.1 Ceramic NPs (CNs)
15.2.1.2 Carbon Nano-Biomaterials
15.2.1.3 Polymer Nano-Biomaterials
15.2.2 Smart Multifunctional Nanobioinks
15.3 Synthesis and Tailoring the Properties of Nanobioinks
15.3.1 Choice of Bioink
15.3.2 Porosity
15.3.3 Surface Properties
15.4 Nanobioinks and Tissue Engineering
15.4.1 Tissue Engineering of Bone and Cartilage
15.4.2 Tissue Engineering of Nerves
15.4.3 Tissue Engineering in Cardiovascular Disease
15.5 Future Outlook
References
Chapter 16 3D Bioprinting from Lab to Industry
16.1 Introduction
16.2 3D Bioprinting and Its Historical Point of View
16.3 Potential of 3D Bioprinting from Lab to Industry
16.4 The Diversity of 3D Bioprinting
16.4.1 Medical Devices
16.4.2 Drug Development
16.4.3 Tissue Engineering
16.5 3D Bioprinting and Human Hearts
16.6 3D Bioprinting and Microfluidic Organ-on-a-Chip Models
16.7 Future Developments
References
Index
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